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Loss Of Atrx Does Not Confer Susceptibility To Osteoarthritis, Lauren A. Solomon, Bailey A. Russell, David Makar, Nathalie G. Bérubé, Frank Beier

Paediatrics Publications

The chromatin remodelling protein ATRX is associated with the rare genetic disorder ATR-X syndrome. This syndrome includes developmental delay, cognitive impairment, and a variety of skeletal deformities. ATRX plays a role in several basic chromatin-mediated cellular events including DNA replication, telomere stability, gene transcription, and chromosome congression and cohesion during cell division. We have used a loss-of-function approach to directly investigate the role of Atrx in the adult skeleton in three different models of selective Atrx loss. We specifically targeted deletion of Atrx to the forelimb mesenchyme, to cartilage and to bone-forming osteoblasts. We previously demonstrated that loss of ATRX …

Family Diversity And Inequality: The Canadian Case, Beaujot Roderic, Jianye Liu, Zenaida R. Ravanera

Population Change and Lifecourse Strategic Knowledge Cluster Discussion Paper Series/ Un Réseau stratégique de connaissances Changements de population et parcours de vie Document de travail

The Second Demographic Transition, including flexibility in types of unions and in entry and exit from unions, has increased the diversity across families. There has been a significant cultural and political dynamic to celebrate this diversity as an increase in individual options, beyond the heterosexual couples with children in a traditional division of labour.

Diversity can be expressed in various ways: economic families or unattached individuals, married or common law, two parents or lone parent, opposite sex or same sex, breadwinner or two earners, traditional division of work and care or collaborative model, couples with and without children, intact or …

The Canadian Government’S Recent Shift Of Diplomacy Away From Traditional Values Toward Economic Benefit For Canada May Do Us No Favours In The Long Run, Erika Simpson

Political Science Publications

No abstract provided.

Data Management In Cloud Environments: Nosql And Newsql Data Stores, Katarina Grolinger, Wilson A. Higashino, Abhinav Tiwari, Miriam Am Capretz

Electrical and Computer Engineering Publications

: Advances in Web technology and the proliferation of mobile devices and sensors connected to the Internet have resulted in immense processing and storage requirements. Cloud computing has emerged as a paradigm that promises to meet these requirements. This work focuses on the storage aspect of cloud computing, specifically on data management in cloud environments. Traditional relational databases were designed in a different hardware and software era and are facing challenges in meeting the performance and scale requirements of Big Data. NoSQL and NewSQL data stores present themselves as alternatives that can handle huge volume of data. Because of the …

Trust Between Specialists And Family Physicians, J. David Spence

Department of Medicine Publications

No abstract provided.

The Relation Between Finger Gnosis And Mathematical Ability: Why Redeployment Of Neural Circuits Best Explains The Finding, Marcie Penner-Wilger, Michael L. Anderson

Brain and Mind Institute Researchers' Publications

This paper elaborates a novel hypothesis regarding the observed predictive relation between finger gnosis and mathematical ability. In brief, we suggest that these two cognitive phenomena have overlapping neural substrates, as the result of the re-use ("redeployment") of part of the finger gnosis circuit for the purpose of representing numbers. We offer some background on the relation and current explanations for it; an outline of our alternate hypothesis; some evidence supporting redeployment over current views; and a plan for further research.

Infections In Children With Down Syndrome And Acute Myeloid Leukemia: A Report From The Canadian Infections In Aml Research Group, Thai Hoa Tran, David Mitchell, David Dix, Sonia Cellot, Marie Chantal Ethier, Biljana Gillmeister, Johann Hitzler, Victor Lewis, Rochelle Yanofsky, Donna L. Johnston, Carol Portwine, Victoria Price, Shayna Zelcer, Mariana Silva, Bruno Michon, Lynette Bowes, Kent Stobart, Josee Brossard, Joseph Beyene, Lillian Sung

Paediatrics Publications

Background: Children with Down syndrome (DS) are at high risk of infectious toxicity when treated with acute lymphoblastic leukemia chemotherapy protocols optimized in children without DS. Our objective was to determine if children with DS and acute myeloid leukemia (AML) have a different risk of infection when treated with chemotherapy protocols developed for children with DS compared to AML treatment protocols developed for children without DS. Methods. We conducted a retrospective, population-based cohort study that included DS children ≤ 18 years of age with de novo, non-M3 AML diagnosed between January 1995 and December 2004, and treated at 15 Canadian …

Uos : A Resource Rerouting Middleware For Ubiquitous Games, Fabricio N. Buzeto, Miriam A M Capretz, Carla D. Castanho, Ricardo P. Jacobi

Electrical and Computer Engineering Publications

Ubiquitous computing (ubicomp) relies on the computation distributed over the environment to simplify the tasks performed by its users. A smart space is an instance of a ubiquitous environment, composed of a dynamic and heterogeneous set of devices that interact to support the execution of distributed smart applications. In this context, mobile devices provide new resources when they join the environment, which disappear when they leave it. This introduces the challenge of self-adaptation, in which smart applications may either include new resources as they become available or replace them when they become unavailable. Ubiquitous games combine ubicomp and computer game …

Image Registration Of Ex-Vivo Mri To Sparsely Sectioned Histology Of Hippocampal And Neocortical Temporal Lobe Specimens., Maged Goubran, Cathie Crukley, Sandrine De Ribaupierre, Terence M Peters, Ali R Khan

Robarts Imaging Publications

Intractable or drug-resistant epilepsy occurs in up to 30% of epilepsy patients, with many of these patients undergoing surgical excision of the affected brain region to achieve seizure control. Recent magnetic resonance imaging (MRI) sequences and analysis techniques have the potential to detect abnormalities not identified with diagnostic MRI protocols. Prospective studies involving pre-operative imaging and collection of surgically-resected tissue provide a unique opportunity for verification and tuning of these image analysis techniques, since direct comparison can be made against histopathology, and can lead to better prediction of surgical outcomes and potentially less invasive procedures. To carry out MRI and …

Assessment Measures For Specific Language Impairment In Brazil: A Systematic Review, Alberto Filgueiras, Lisa M.D. Archibald, J. Landeira-Fernandez

Paediatrics Publications

Specific Language Impairment (SLI) is defined as an unexpected failure in linguistic abilities during a child's early years of development. Children with SLI do not present significant impairment in nonverbal intellectual outcomes and do not lack normal environmental exposure to language. Brazilian and worldwide researchers have sought to understand the cultural implications of SLI in the Brazilian Portuguese language. Standardized and validated measures must be used in empirical studies. The present study systematically reviewed the instruments used to assess linguistic abilities in quantitative SLI research in Brazil. Three databases were chosen: Medline, SciELO, and Google Scholar. From a total of …

Targeted Loss Of The Atr-X Syndrome Protein In The Limb Mesenchyme Of Mice Causes Brachydactyly, Lauren A. Solomon, Bailey A. Russell, L. Ashley Watson, Frank Beier, Nathalie G. Bérubé

Paediatrics Publications

ATR-X syndrome is a rare genetic disorder caused by mutations in the ATRX gene. Affected individuals are cognitively impaired and display a variety of developmental abnormalities, including skeletal deformities. To investigate the function of ATRX during skeletal development, we selectively deleted the gene in the developing forelimb mesenchyme of mice. The absence of ATRX in the limb mesenchyme resulted in shorter digits, or brachydactyly, a defect also observed in a subset of ATR-X patients. This phenotype persisted until adulthood, causing reduced grip strength and altered gait in mutant mice. Examination of the embryonic ATRX-null forelimbs revealed a significant increase in …

Role Of Interleukin-10 In Endochondral Bone Formation In Mice: Anabolic Effect Via The Bone Morphogenetic Protein/Smad Pathway, Youn Kwan Jung, Gun Woo Kim, Hye Ri Park, Eun Ju Lee, Je Yong Choi, Frank Beier, Seung Woo Han

Paediatrics Publications

Objective: Interleukin-10 (IL-10) is a pleiotropic immunoregulatory cytokine with a chondroprotective effect that is elevated in cartilage and synovium in patients with osteoarthritis. However, the role of IL-10 during endochondral bone formation and its mechanism of action have not been elucidated. Methods: IL-10-/- mice and IL-10-treated tibial organ cultures were used to study loss and gain of IL-10 functions, respectively, during endochondral bone formation. Primary chondrocytes from the long bones of mouse embryos were cultured with and without IL-10. To assess the role of IL-10 in chondrogenic differentiation, we conducted mesenchymal cell micromass cultures. Results: The lengths of whole skeletons …

Erratum: Influence Of Health Information Levels On Postpartum Depression (Archives Of Women's Mental Health Doi: 10.1007/S00737-013-0368-5), Sabrina Youash, M. Karen Campbell, William Avison, Debbie Penava, Verinder Sharma, Bin Xie

Paediatrics Publications

No abstract provided.

The Politics Of Denying Communion To Catholic Elected Officials, William D. Blake, Amanda Friesen

Political Science Publications

In his 2004 presidential campaign, John Kerry, a Catholic, was threatened with being denied Holy Communion because of his pro-choice voting record. This article investigates the extent to which communion denial impacted Catholic elected officials and analyzes public attitudes regarding communion denial for Kerry. The results of our analysis suggest that, despite heavy media coverage, few bishops endorsed the communion denial and few pro-choice Catholic officials were threatened. While the data also indicate there are meaningful political implications for public attitudes on communion denial, the tactic does not command support from many Catholics.

Fair Dealing Law & The Contractual Environment, Margaret Ann Wilkinson

Law Presentations

No abstract provided.

Mice With Deficient Bk Channel Function Show Impaired Prepulse Inhibition And Spatial Learning, But Normal Working And Spatial Reference Memory, Marei Typlt, Magdalena Mirkowski, Erin Azzopardi, Lukas Ruettiger, Peter Ruth, Susanne Schmid

Anatomy and Cell Biology Publications

Genetic variations in the large-conductance, voltage- and calcium activated potassium channels (BK channels) have been recently implicated in mental retardation, autism and schizophrenia which all come along with severe cognitive impairments. In the present study we investigate the effects of functional BK channel deletion on cognition using a genetic mouse model with a knock-out of the gene for the pore forming α-subunit of the channel. We tested the F1 generation of a hybrid SV129/C57BL6 mouse line in which the slo1 gene was deleted in both parent strains.

We first evaluated hearing and motor function to establish the suitability of this …

Functional And Structural Changes Throughout The Auditory System Following Congenital And Early-Onset Deafness: Implications For Hearing Restoration, Blake E. Butler, Stephen G. Lombar

Brain and Mind Institute Researchers' Publications

The absence of auditory input, particularly during development, causes widespread changes in the structure and function of the auditory system, extending from peripheral structures into auditory cortex. In humans, the consequences of these changes are far-reaching and often include detriments to language acquisition, and associated psychosocial issues.Much of what is currently known about the nature of deafness-related changes to auditory structures comes from studies of congenitally deaf or early-deafened animal models. Fortunately, the mammalian auditory system shows a high degree of preservation among species, allowing for generalization from these models to the human auditory system. This review begins with a …

Mapping The Invisible: A Framework For Tracking Covid-19 Spread Among College Students With Google Location Data, Prajindra Sankar Krishnan, Chai Phing Chen, Gamal Alkawsi, Sieh Kiong Tiong, Luiz Fernando Capretz

Electrical and Computer Engineering Publications

The COVID-19 pandemic and the implementation of social distancing policies have rapidly changed people's visiting patterns, as reflected in mobility data that tracks mobility traffic using location trackers on cell phones. However, the frequency and duration of concurrent occupancy at specific locations govern the transmission rather than the number of customers visiting. Therefore, understanding how people interact in different locations is crucial to target policies, inform contact tracing, and prevention strategies. This study proposes an efficient way to reduce the spread of the virus among on-campus university students by developing a self-developed Google History Location Extractor and Indicator software based …

Arrangement Of Sympathetic Fibers Within The Human Common Peroneal Nerve: Implications For Microneurography, Rebecca P.R. Tompkins, C. W.J. Melling, Timothy D. Wilson, Brent D. Bates, J. Kevin Shoemaker

Paediatrics Publications

Recently, interest has grown in the firing patterns of individual or multiunit action potential firing patterns in human muscle sympathetic nerve recordings using microneurography. Little is known, however, about sympathetic fiber distribution in human lower limb nerves that will affect the multiunit recordings. Therefore, the purpose of this study was to examine the sympathetic fiber distribution within the human common peroneal nerve using immunohistochemical techniques (tyrosine hydroxylase, avidin-biotin complex technique). Five-micrometer transverse and 10-μm longitudinal sections, fixed in formaldehyde, were obtained from the peroneal nerve that had been harvested from three human cadavers (83 ± 11 yr) within 24 h …

Integration And “Welcome-Ability” Indexes: Measures Of Community Capacity To Integrate Immigrants, Zenaida R. Ravanera, Victoria Esses, Rajulton Fernando

Population Change and Lifecourse Strategic Knowledge Cluster Discussion Paper Series/ Un Réseau stratégique de connaissances Changements de population et parcours de vie Document de travail

This paper aims at clarifying the applicability of the theory of micro-macro links to the general concept of “integration” and illustrates two distinct methods of measuring the concept at individual and community levels. In particular, two indexes are developed, the first one called welcome-ability index, to measure the capacities of communities to welcome and integrate newcomers, and the second called integration index, to measure economic, social, and political integration of individuals. The first, a community-level measure, takes into account opportunities and facilities, including employment opportunities, facilities for health care and positive attitudes towards immigrants. The second, an individual-level measure, takes …

Bdnf In The Dentate Gyrus Is Required For Consolidation Of "Pattern-Separated" Memories., Pedro Bekinschtein, Brianne A Kent, Charlotte A Oomen, Gregory D Clemenson, Fred H Gage, Lisa M Saksida, Timothy J Bussey

Brain and Mind Institute Researchers' Publications

Successful memory involves not only remembering information over time, but also keeping memories distinct and less confusable. The computational process for making representations for similar input patterns more distinct from each other has been referred to as "pattern separation." In this work, we developed a set of behavioral conditions that allowed us to manipulate the load for pattern separation at different stages of memory. Thus, we provide experimental evidence that a brain-derived neurotrophic factor (BDNF)-dependent pattern separation process occurs during the encoding/storage/consolidation, but not the retrieval stage of memory processing. We also found that a spontaneous increase in BDNF in …

Down In The Dumps, Erika Simpson

Political Science Publications

No abstract provided.

Reduced Expression Of The Vesicular Acetylcholine Transporter And Neurotransmitter Content Affects Synaptic Vesicle Distribution And Shape In Mouse Neuromuscular Junction, Hermann A. Rodrigues, Matheus De C. Fonseca, Wallace L. Camargo, Patricia M. A. Lima, Patricia M. Martinelli, Ligia A. Naves, Vania F. Prado, Marco A. M. Prado, Cristina Guatimosim

Anatomy and Cell Biology Publications

In vertebrates, nerve muscle communication is mediated by the release of the neurotransmitter acetylcholine packed inside synaptic vesicles by a specific vesicular acetylcholine transporter (VAChT). Here we used a mouse model (VAChT KDHOM) with 70% reduction in the expression of VAChT to investigate the morphological and functional consequences of a decreased acetylcholine uptake and release in neuromuscular synapses. Upon hypertonic stimulation, VAChT KDHOM mice presented a reduction in the amplitude and frequency of miniature endplate potentials, FM 1-43 staining intensity, total number of synaptic vesicles and altered distribution of vesicles within the synaptic terminal. In contrast, under electrical stimulation or …

An Investigation Of Changes In Regional Gray Matter Volume In Cardiovascular Disease Patients, Pre And Post Cardiovascular Rehabilitation, U. C. Anazodo, J. K. Shoemaker, N. Suskin, K. S. St. Lawrence

Paediatrics Publications

Cognitive function decline secondary to cardiovascular disease has been reported. However, little is known about the impact of coronary artery disease (CAD) on the aging brain macrostructure or whether exercise training, in the context of cardiovascular rehabilitation, can affect brain structure following a coronary event. This study employed voxel-based morphometry of high resolution structural MRI images to investigate; 1) changes in regional gray matter volume (GMV) in CAD patients compared to age-matched controls, and 2) the effects of a six-month exercise-based cardiovascular rehabilitation program on CAD-related GMV decline. Compared to controls, significant decreases in regional GMV were found in the …

One, Two And Three-Dimensional Ultrasound Measurements Of Carotid Atherosclerosis Before And After Cardiac Rehabilitation: Preliminary Results Of A Randomized Controlled Trial., Tamas J Lindenmaier, Daniel N Buchanan, Damien Pike, Tim Hartley, Robert D Reid, J David Spence, Richard Chan, Michael Sharma, Peter L Prior, Neville Suskin, Grace Parraga

Medical Biophysics Publications

BACKGROUND: It is still not known how patients who are post-transient ischemic attack (TIA) or post-stroke might benefit from prospectively planned comprehensive cardiac rehabilitation (CCR). In this pilot evaluation of a larger ongoing randomized-controlled-trial, we evaluated ultrasound (US) measurements of carotid atherosclerosis in subjects following TIA or mild non-disabling stroke and their relationship with risk factors before and after 6-months of CCR.

METHODS: Carotid ultrasound (US) measurements of one-dimensional intima-media-thickness (IMT), two-dimensional total-plaque-area (TPA), three-dimensional total-plaque-volume (TPV) and vessel-wall-volume (VWV) were acquired before and after 6-months CCR for 39 subjects who had previously experienced a TIA and provided written informed …

Genealogy And The Law In Canada 2013, Margaret Ann Wilkinson

Law Presentations

No abstract provided.

Veracity Roadmap: Is Big Data Objective, Truthful And Credible?, Victoria Rubin, Tatiana Lukoianova

FIMS Publications

This paper argues that big data can possess different characteristics, which affect its quality. Depending on its origin, data processing technologies, and methodologies used for data collection and scientific discoveries, big data can have biases, ambiguities, and inaccuracies which need to be identified and accounted for to reduce inference errors and improve the accuracy of generated insights. Big data veracity is now being recognized as a necessary property for its utilization, complementing the three previously established quality dimensions (volume, variety, and velocity), But there has been little discussion of the concept of veracity thus far. This paper provides a roadmap …

Trajectories Of Health-Related Quality Of Life In Children With Epilepsy: A Cohort Study, Mark A. Ferro, Carol S. Camfield, Simon D. Levin, Mary Lou Smith, Samuel Wiebe, Guangyong Zou, Kathy N. Speechley

Paediatrics Publications

Purpose Little is known about subgroups of children with epilepsy who may experience less favorable outcomes over time. The objectives of this study were to document trajectories of health-related quality of life (HRQL) and to identify predictors of the trajectory group in children with new-onset epilepsy. Methods Data were obtained from the Health Related Quality of Life in Children with Epilepsy Study, a prospective multisite study of children 4-12 years old with new-onset epilepsy followed for 24 months. Health-related quality of life was measured using the Quality of Life in Childhood Epilepsy questionnaire. Trajectories of HRQL were investigated using latent …

Cognitive Vulnerability To Depression During Middle Childhood: Stability And Associations With Maternal Affective Styles And Parental Depression, Elizabeth P. Hayden, Thomas M. Olino, Sarah V.M. Mackrell, Patricia L. Jordan, Jasmine Desjardins, Patrice Katsiroumbas

Paediatrics Publications

Theories of cognitive vulnerability to depression (CVD) imply that CVD is early-emerging and trait-like; however, little longitudinal work has tested this premise in middle childhood, or examined theoretically relevant predictors of child CVD. We examined test-retest correlations of self-referent encoding task performance and self-reported attributional styles and their associations with parental characteristics in 205 seven-year-olds. At baseline, child CVD was assessed, structured clinical interviews were conducted with parents, and ratings of observed maternal affective styles were made. Children's CVD was re-assessed approximately one and two years later. Both measures of children's CVD were prospectively and concurrently associated with children's depressive …

Erratum: Cyp3a4 And Seasonal Variation In Vitamin D Status In Addition To Cyp2d6 Contribute To Therapeutic Endoxifen Level During Tamoxifen Therapy (Breast Cancer Research And Treatment (2013) 139 (95-105) Doi 10.1007/S10549-013-2511-4), Wendy A. Teft, Inna Y. Gong, Brian Dingle, Kylea Potvin, Jawaid Younus, Theodore A. Vandenberg, Muriel Brackstone, Francisco E. Perera, Yun Hee Choi, Guangyong Zou, Robin M. Legan, Rommel G. Tirona, Richard B. Kim

Paediatrics Publications

No abstract provided.