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Is It Time To Stop Teaching Bystanders Ventilation As Part Of Pediatric Cardiopulmonary Resuscitation?, Allan De Caen, Janice A. Tijssen
Is It Time To Stop Teaching Bystanders Ventilation As Part Of Pediatric Cardiopulmonary Resuscitation?, Allan De Caen, Janice A. Tijssen
Paediatrics Publications
No abstract provided.
An Rb-Ezh2 Complex Mediates Silencing Of Repetitive Dna Sequences, Charles A. Ishak, Aren E. Marshall, Daniel T. Passos, Carlee R. White, Seung J. Kim, Matthew J. Cecchini, Sara Ferwati, William A. Macdonald, Christopher J. Howlett, Ian D. Welch, Seth M. Rubin, Mellissa R.W. Mann, Frederick A. Dick
An Rb-Ezh2 Complex Mediates Silencing Of Repetitive Dna Sequences, Charles A. Ishak, Aren E. Marshall, Daniel T. Passos, Carlee R. White, Seung J. Kim, Matthew J. Cecchini, Sara Ferwati, William A. Macdonald, Christopher J. Howlett, Ian D. Welch, Seth M. Rubin, Mellissa R.W. Mann, Frederick A. Dick
Paediatrics Publications
Repetitive genomic regions include tandem sequence repeats and interspersed repeats, such as endogenous retroviruses and LINE-1 elements. Repressive heterochromatin domains silence expression of these sequences through mechanisms that remain poorly understood. Here, we present evidence that the retinoblastoma protein (pRB) utilizes a cell-cycle-independent interaction with E2F1 to recruit enhancer of zeste homolog 2 (EZH2) to diverse repeat sequences. These include simple repeats, satellites, LINEs, and endogenous retroviruses as well as transposon fragments. We generated a mutant mouse strain carrying an F832A mutation in Rb1 that is defective for recruitment to repetitive sequences. Loss of pRB-EZH2 complexes from repeats disperses H3K27me3 …
Bronchodilators For The Prevention And Treatment Of Chronic Lung Disease In Preterm Infants, Geraldine Ng, Orlando Da Silva, Arne Ohlsson
Bronchodilators For The Prevention And Treatment Of Chronic Lung Disease In Preterm Infants, Geraldine Ng, Orlando Da Silva, Arne Ohlsson
Paediatrics Publications
Background: Chronic lung disease (CLD) occurs frequently in preterm infants. Bronchodilators have the potential effect of dilating small airways with muscle hypertrophy. Increased compliance and tidal volume and decreased pulmonary resistance have been documented with the use of bronchodilators in infants with CLD. Therefore, bronchodilators might have a role in the prevention and treatment of CLD. Objectives: To determine the effect of bronchodilators given as prophylaxis or as treatment for CLD on mortality and other complications of preterm birth in infants at risk for or identified as having CLD. Search methods: On 2016 March 7, we used the standard strategy …
The Defining Dna Methylation Signature Of Floating-Harbor Syndrome, Rebecca L. Hood, Laila C. Schenkel, Sarah M. Nikkel, Peter J. Ainsworth, Guillaume Pare, Kym M. Boycott, Dennis E. Bulman, Bekim Sadikovic
The Defining Dna Methylation Signature Of Floating-Harbor Syndrome, Rebecca L. Hood, Laila C. Schenkel, Sarah M. Nikkel, Peter J. Ainsworth, Guillaume Pare, Kym M. Boycott, Dennis E. Bulman, Bekim Sadikovic
Paediatrics Publications
Floating-Harbor syndrome (FHS) is an autosomal dominant genetic condition characterized by short stature, delayed osseous maturation, expressive language impairment, and unique facial dysmorphology. We previously identified mutations in the chromatin remodeling protein SRCAP (SNF2-related CBP Activator Protein) as the cause of FHS. SRCAP has multiple roles in chromatin and transcriptional regulation; however, specific epigenetic consequences of SRCAP mutations remain to be described. Using high resolution genome-wide DNA methylation analysis, we identified a unique and highly specific DNA methylation "epi-signature" in the peripheral blood of individuals with FHS. Both hyper and hypomethylated loci are distributed across the genome, preferentially occurring in …
Experiences Of Caregivers Of Children With Inherited Metabolic Diseases: A Qualitative Study, Shabnaz Siddiq, Brenda J. Wilson, Ian D. Graham, Monica Lamoureux, Sara D. Khangura, Kylie Tingley, Laure Tessier, Pranesh Chakraborty, Doug Coyle, Sarah Dyack, Jane Gillis, Cheryl Greenberg, Robin Z. Hayeems, Shailly Jain-Ghai, Jonathan B. Kronick, Anne Marie Laberge, Julian Little, John J. Mitchell, Chitra Prasad, Komudi Siriwardena, Rebecca Sparkes, Kathy N. Speechley, Sylvia Stockler, Yannis Trakadis, Sarah Wafa, Jagdeep Walia
Experiences Of Caregivers Of Children With Inherited Metabolic Diseases: A Qualitative Study, Shabnaz Siddiq, Brenda J. Wilson, Ian D. Graham, Monica Lamoureux, Sara D. Khangura, Kylie Tingley, Laure Tessier, Pranesh Chakraborty, Doug Coyle, Sarah Dyack, Jane Gillis, Cheryl Greenberg, Robin Z. Hayeems, Shailly Jain-Ghai, Jonathan B. Kronick, Anne Marie Laberge, Julian Little, John J. Mitchell, Chitra Prasad, Komudi Siriwardena, Rebecca Sparkes, Kathy N. Speechley, Sylvia Stockler, Yannis Trakadis, Sarah Wafa, Jagdeep Walia
Paediatrics Publications
Background: We sought to understand the experiences of parents/caregivers of children with inherited metabolic diseases (IMD) in order to inform strategies for supporting patients and their families. We investigated their experiences regarding the management of disease, its impact on child and family life, and interactions with the health care system. Methods: From four Canadian centres, we conducted semi-structured telephone interviews with parents/caregivers of children with an IMD who were born between 2006 and 2015 and who were participating in a larger cohort study. Participants were selected with the aim of achieving a diverse sample with respect to treatment centre, IMD, …
Macrocephaly And Right Arm Disuse In A 7-Month-Old Boy, Michael D. Staudt, Jason D. Morgenstern, Andrea Neufeld, Adrianna Ranger
Macrocephaly And Right Arm Disuse In A 7-Month-Old Boy, Michael D. Staudt, Jason D. Morgenstern, Andrea Neufeld, Adrianna Ranger
Paediatrics Publications
No abstract provided.
Newborn With Scalp Swelling, Jade Séguin, Charisse Kwan
Newborn With Scalp Swelling, Jade Séguin, Charisse Kwan
Paediatrics Publications
No abstract provided.
Pregnant Women's Perceptions Of Exposure To Brominated Flame Retardants, A. Lane, C. G. Goodyer, F. Rab, J. M. Ashley, S. Sharma, A. Hodgson, J. Nisker
Pregnant Women's Perceptions Of Exposure To Brominated Flame Retardants, A. Lane, C. G. Goodyer, F. Rab, J. M. Ashley, S. Sharma, A. Hodgson, J. Nisker
Paediatrics Publications
Background: Recent media reports on human studies associating brominated flame retardants (BFRs) in household products in pregnancy with urogenital anomalies in boys and endocrine disruption in both sexes. We sought to explore the perceptions of pregnant women of brominated flame retardant (BFR) exposure, in light of recent media reports on the adverse health effects of BFR exposure prenatally. Methods: Pregnant women were recruited for interviews through posters and pamphlets in prenatal clinics, prenatal fairs and community centres. Interviews were audiotaped and transcribed verbatim for Charmaz-based qualitative analysis supported by NVIVO 10™. Results: Theoretical sufficiency was reached after analyzing the interviews …
The Association Between Social Cohesion And Physical Activity In Canada: A Multilevel Analysis, Calvin Yip, Sisira Sarma, Piotr Wilk
The Association Between Social Cohesion And Physical Activity In Canada: A Multilevel Analysis, Calvin Yip, Sisira Sarma, Piotr Wilk
Paediatrics Publications
Although previous research has shown that social cohesion may promote physical activity, social cohesion at the individual level was not always differentiated from social cohesion at the community level, and studies were often limited to specific population subgroups or geographical areas. We addressed the above limitations through the use of a multilevel modelling approach and nationally-representative data from the 2009–2014 Canadian Community Health Survey. Physical activity level was operationalized as average daily energy expenditure; social cohesion was assessed by self-rated sense of belonging to the local community; and communities were represented by Canada's Forward Sortation Areas. The sample included 245,150 …
Ablation De L'Endomètre Dans La Prise En Charge Des Saignements Utérins Anormaux, Philippe Laberge, Nicholas Leyland, Ally Murji, Claude Fortin, Paul Martyn, George Vilos
Ablation De L'Endomètre Dans La Prise En Charge Des Saignements Utérins Anormaux, Philippe Laberge, Nicholas Leyland, Ally Murji, Claude Fortin, Paul Martyn, George Vilos
Paediatrics Publications
No abstract provided.
Atp2c2 Is Transcribed From A Unique Transcriptional Start Site In Mouse Pancreatic Acinar Cells, Melissa A. Fenech, Caitlin M. Sullivan, Lucimar T. Ferreira, Rashid Mehmood, William A. Macdonald, Peter B. Stathopulos, Christopher L. Pin
Atp2c2 Is Transcribed From A Unique Transcriptional Start Site In Mouse Pancreatic Acinar Cells, Melissa A. Fenech, Caitlin M. Sullivan, Lucimar T. Ferreira, Rashid Mehmood, William A. Macdonald, Peter B. Stathopulos, Christopher L. Pin
Paediatrics Publications
Proper regulation of cytosolic Ca2+ is critical for pancreatic acinar cell function. Disruptions in normal Ca2+ concentrations affect numerous cellular functions and are associated with pancreatitis. Membrane pumps and channels regulate cytosolic Ca2+ homeostasis by promoting rapid Ca2+ movement. Determining how expression of Ca2+ modulators is regulated and the cellular alterations that occur upon changes in expression can provide insight into initiating events of pancreatitis. The goal of this study was to delineate the gene structure and regulation of a novel pancreas-specific isoform for Secretory Pathway Ca2+ ATPase 2 (termed SPCA2C), which is encoded from the Atp2c2 gene. Using Next …
Detection Of Α-Thalassemia By Using Multiplex Ligation-Dependent Probe Amplification As An Additional Method For Rare Mutations In Southern Turkey, Ozge Ozalp Yuregir, Akif Ayaz, Sinem Yalcintepe, Sezin Canbek, Didar Yanardag Acik, Basak Taburoglu Yilmaz, Tugce B. Balci
Detection Of Α-Thalassemia By Using Multiplex Ligation-Dependent Probe Amplification As An Additional Method For Rare Mutations In Southern Turkey, Ozge Ozalp Yuregir, Akif Ayaz, Sinem Yalcintepe, Sezin Canbek, Didar Yanardag Acik, Basak Taburoglu Yilmaz, Tugce B. Balci
Paediatrics Publications
α-thalassemia is the most common single gene disorder in the Cukurova Region in Turkey. It is therefore routinely screened, including premaritally, in our region. The heterogeneous molecular basis of the disease makes α-thalassemia mutation detection difficult and complex. Besides well established methods, multiplex ligation dependent probe amplification (MLPA) is known as an effective, simple and specific method for the detection and characterization of deletions and duplications. We employed MLPA testing to 30 patients with hematological parameters suggestive of α-thalassemia carrier status but was negative for α-thalassemia with conventional reverse dot blot hybridization (RDB). We found α-globin gene deletions in 3 …
Characterization And Immunomodulatory Effects Of Canine Adipose Tissue- And Bone Marrow-Derived Mesenchymal Stromal Cells, Keith A. Russell, Natalie H.C. Chow, David Dukoff, Thomas W.G. Gibson, Jonathan La Marre, Dean H. Betts, Thomas G. Koch
Characterization And Immunomodulatory Effects Of Canine Adipose Tissue- And Bone Marrow-Derived Mesenchymal Stromal Cells, Keith A. Russell, Natalie H.C. Chow, David Dukoff, Thomas W.G. Gibson, Jonathan La Marre, Dean H. Betts, Thomas G. Koch
Paediatrics Publications
Background Mesenchymal stromal cells (MSC) hold promise for both cell replacement and immune modulation strategies owing to their progenitor and non-progenitor functions, respectively. Characterization of MSC from different sources is an important and necessary step before clinical use of these cells is widely adopted. Little is known about the biology and function of canine MSC compared to their mouse or human counterparts. This knowledge-gap impedes development of canine evidence-based MSC technologies. Hypothesis and Objectives We hypothesized that canine adipose tissue (AT) and bone marrow (BM) MSC (derived from the same dogs) will have similar differentiation and immune modulatory profiles. Our …
Integrin-Linked Kinase And Elmo2 Modulate Recycling Endosomes In Keratinocytes, Ernest Ho, Iordanka A. Ivanova, Lina Dagnino
Integrin-Linked Kinase And Elmo2 Modulate Recycling Endosomes In Keratinocytes, Ernest Ho, Iordanka A. Ivanova, Lina Dagnino
Paediatrics Publications
The formation of tight cell-cell junctions is essential in the epidermis for its barrier properties. In this tissue, keratinocytes follow a differentiation program tightly associated with their movement from the innermost basal to the outer suprabasal layers, and with changes in their cell-cell adhesion profile. Intercellular adhesion in keratinocytes is mediated through cell-cell contacts, including E-cadherin-based adherens junctions. Although the mechanisms that mediate E-cadherin delivery to the plasma membrane have been widely studied in simple epithelia, this process is less well understood in the stratified epidermis. In this study, we have investigated the role of Engulfment and Cell Motility 2 …
A Qualitative Examination Of Women's Self-Presentation And Social Physique Anxiety During Injury Rehabilitation, Molly V. Driediger, Carly D. Mckay, Craig R. Hall, Paul S. Echlin
A Qualitative Examination Of Women's Self-Presentation And Social Physique Anxiety During Injury Rehabilitation, Molly V. Driediger, Carly D. Mckay, Craig R. Hall, Paul S. Echlin
Paediatrics Publications
Objective To understand women's self-presentation experiences in the rehabilitation setting, and their attitudes and preferences toward the social and physical features of the rehabilitation environment. Design Qualitative study. Setting Outpatient physiotherapy clinic. Participants Ten women (age 18 to 64) with high social physique anxiety (Social Physique Anxiety Scale score ≥25) referred for physiotherapy following acute injury. Main outcome measures Semi-structured interviews were conducted prior to commencement of treatment, and again after a third treatment session. Results Participants experienced extensive self-presentational concerns that were intensified due to the nature of the physiotherapy environment. The women reported that their self-presentational anxiety did …
Can The New Ckd-Epi Btp-B2m Formula Be Applied In Children?, Guido Filler, Ana Catalina Alvarez-Elías, Katherine D. Westreich, Shih Han S. Huang, Robert M. Lindsay
Can The New Ckd-Epi Btp-B2m Formula Be Applied In Children?, Guido Filler, Ana Catalina Alvarez-Elías, Katherine D. Westreich, Shih Han S. Huang, Robert M. Lindsay
Paediatrics Publications
Although measuring creatinine to determine kidney function is currently the clinical standard, new markers such as beta-trace protein (BTP) and beta-2-microglobulin (B2M) are being investigated in an effort to measure glomerular filtration rate more accurately. In their recent publication, Inker et al. (Am J Kidney Dis 2015; 67:40–48) explored the use of these two relatively new markers in combination with some commonly available clinical characteristics in a large cohort of adults with chronic kidney disease. Their research led them to develop three formulae using BTP, B2M, and a combination of the two. The combined formula is particularly attractive as it …
11Β-Hydroxysteroid Dehydrogenase Type 1(11Β-Hsd1) Mediates Insulin Resistance Through Jnk Activation In Adipocytes, Kesong Peng, Yong Pan, Jieli Li, Zia Khan, Mendi Fan, Haimin Yin, Chao Tong, Yunjie Zhao
11Β-Hydroxysteroid Dehydrogenase Type 1(11Β-Hsd1) Mediates Insulin Resistance Through Jnk Activation In Adipocytes, Kesong Peng, Yong Pan, Jieli Li, Zia Khan, Mendi Fan, Haimin Yin, Chao Tong, Yunjie Zhao
Paediatrics Publications
Glucocorticoids are used to treat a number of human diseases but often lead to insulin resistance and metabolic syndrome. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a key enzyme that catalyzes the intracellular conversion of cortisone to physiologically active cortisol. Despite the known role of 11β-HSD1 and active glucocorticoid in causing insulin resistance, the molecular mechanisms by which insulin resistance is induced remain elusive. The aim of this study is to identify these mechanisms in high fat diet (HFD) experimental models. Mice on a HFD were treated with 11β-HSD1 inhibitor as well as a JNK inhibitor. We then treated 3T3-L1-derived adipocytes …
A Core Outcome Set For Neonatal Abstinence Syndrome: Study Protocol For A Systematic Review, Parent Interviews And A Delphi Survey, Lauren E. Kelly, Lauren M. Jansson, Wendy Moulsdale, Jodi Pereira, Sarah Simpson, Astrid Guttman, Karel Allegaert, Lisa Askie, Henry Roukema, Thierry Lacaze, Jonathan M. Davis, Loretta Finnegan, Paula Williamson, Martin Offringa
A Core Outcome Set For Neonatal Abstinence Syndrome: Study Protocol For A Systematic Review, Parent Interviews And A Delphi Survey, Lauren E. Kelly, Lauren M. Jansson, Wendy Moulsdale, Jodi Pereira, Sarah Simpson, Astrid Guttman, Karel Allegaert, Lisa Askie, Henry Roukema, Thierry Lacaze, Jonathan M. Davis, Loretta Finnegan, Paula Williamson, Martin Offringa
Paediatrics Publications
Background: The prevalence of neonatal abstinence syndrome (NAS) is increasing globally resulting in an increased incidence of adverse neonatal outcomes and health system costs. Evidence regarding the effectiveness of NAS prevention and management strategies is very weak and further research initiatives are critically needed to support meta-analysis and clinical practice guidelines. In NAS research, the choice of outcomes and the use of valid, responsive and feasible measurement instruments are crucial. There is currently no consensus and evidence-based core outcome set (COS) for NAS. Methods/design: The development of the NAS-COS will include five stages led by an international Multidisciplinary Steering Committee: …
International Pediatric Otolaryngology Group (Ipog) Consensus Recommendations: Hearing Loss In The Pediatric Patient, Bryan J. Liming, John Carter, Alan Cheng, Daniel Choo, John Curotta, Daniela Carvalho, John A. Germiller, Stephen Hone, Margaret A. Kenna, Natalie Loundon, Diego Preciado, Anne Schilder, Brian J. Reilly, Stephane Roman, Julie Strychowsky, Jean Michel Triglia, Nancy Young, Richard J.H. Smith
International Pediatric Otolaryngology Group (Ipog) Consensus Recommendations: Hearing Loss In The Pediatric Patient, Bryan J. Liming, John Carter, Alan Cheng, Daniel Choo, John Curotta, Daniela Carvalho, John A. Germiller, Stephen Hone, Margaret A. Kenna, Natalie Loundon, Diego Preciado, Anne Schilder, Brian J. Reilly, Stephane Roman, Julie Strychowsky, Jean Michel Triglia, Nancy Young, Richard J.H. Smith
Paediatrics Publications
Objective To provide recommendations for the workup of hearing loss in the pediatric patient. Methods Expert opinion by the members of the International Pediatric Otolaryngology Group. Results Consensus recommendations include initial screening and diagnosis as well as the workup of sensorineural, conductive and mixed hearing loss in children. The consensus statement discusses the role of genetic testing and imaging and provides algorithms to guide the workup of children with hearing loss. Conclusion The workup of children with hearing loss can be guided by the recommendations provided herein.
Movement Disorders Associated With Hemochromatosis, Niraj Kumar, Philippe Rizek, Bekim Sadikovic, Paul C. Adams, Mandar Jog
Movement Disorders Associated With Hemochromatosis, Niraj Kumar, Philippe Rizek, Bekim Sadikovic, Paul C. Adams, Mandar Jog
Paediatrics Publications
Background: Hereditary hemochromatosis (HH) is a genetic disorder causing pathological iron deposition and functional impairment of various organs, predominantly the liver. We assessed patients with HH for the presence of movement disorders. Methods: We reviewed the charts of 616 patients with HH who attended hemochromatosis clinic at London Health Sciences Centre, London, ON, Canada, from 1988 to 2015. Results: We found three HH patients with movement disorders, without any other major systemic manifestation. One had parkinsonism, another had chorea, and the third had tremor. All three patients had evidence of iron deposition in the brain, affecting the basal ganglia in …
The Effect Of A Full Bladder On Proportions Of Diagnostic Ultrasound Studies In Children With Suspected Appendicitis, Marshall Ross, Sasha Selby, Naveen Poonai, Helena Liu, Shabnam Minoosepehr, Graham Boag, Robin Eccles, Graham Thompson
The Effect Of A Full Bladder On Proportions Of Diagnostic Ultrasound Studies In Children With Suspected Appendicitis, Marshall Ross, Sasha Selby, Naveen Poonai, Helena Liu, Shabnam Minoosepehr, Graham Boag, Robin Eccles, Graham Thompson
Paediatrics Publications
Objectives: We examined the effect of a full bladder on proportions of diagnostic ultrasound (US) studies in children with suspected appendicitis. We also examined the effect of a full bladder on proportions of fully visualized ovaries on US in children with suspected appendicitis. Methods: We conducted a retrospective health record review of children aged 2-17 years presenting to a tertiary pediatric emergency department (ED) with suspected appendicitis who had an ultrasound performed. We compared proportions of diagnostic US studies in children with full and sub-optimally filled bladders. We also compared proportions of ovarian visualization in females with full and sub-optimally …
Clinical Validation Of Fragile X Syndrome Screening By Dna Methylation Array, Laila C. Schenkel, Charles Schwartz, Cindy Skinner, David I. Rodenhiser, Peter J. Ainsworth, Guillaume Pare, Bekim Sadikovic
Clinical Validation Of Fragile X Syndrome Screening By Dna Methylation Array, Laila C. Schenkel, Charles Schwartz, Cindy Skinner, David I. Rodenhiser, Peter J. Ainsworth, Guillaume Pare, Bekim Sadikovic
Paediatrics Publications
Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. It is most frequently caused by an abnormal expansion of the CGG trinucleotide repeat (>200 repeats) located in the promoter of the fragile X mental retardation gene (FMR1), resulting in promoter DNA hypermethylation and gene silencing. Current clinical tests for FXS are technically challenging and labor intensive, and may involve use of hazardous chemicals or radioisotopes. We clinically validated the Illumina Infinium HumanMethylation450 DNA methylation array for FXS screening. We assessed genome-wide and FMR1-specific DNA methylation in 32 males previously diagnosed with FXS, including nine with …
Exercise And Pregnancy In Recreational And Elite Athletes: 2016 Evidence Summary From The Ioc Expert Group Meeting, Lausanne. Part 2 - The Effect Of Exercise On The Fetus, Labour And Birth, Kari Bø, Raul Artal, Ruben Barakat, Wendy Brown, Michael Dooley, Kelly R. Evenson, Lene A.H. Haakstad, Karin Larsen, Bengt Joubert, Don Mcconnell, Cheri Nijssen-Jordan, Martin Pusic, Martin Reed, Norm Silver, Ian Stiell, Brett Taylor, Michael Vassilyadi
Exercise And Pregnancy In Recreational And Elite Athletes: 2016 Evidence Summary From The Ioc Expert Group Meeting, Lausanne. Part 2 - The Effect Of Exercise On The Fetus, Labour And Birth, Kari Bø, Raul Artal, Ruben Barakat, Wendy Brown, Michael Dooley, Kelly R. Evenson, Lene A.H. Haakstad, Karin Larsen, Bengt Joubert, Don Mcconnell, Cheri Nijssen-Jordan, Martin Pusic, Martin Reed, Norm Silver, Ian Stiell, Brett Taylor, Michael Vassilyadi
Paediatrics Publications
This is Part 2 of 5 in the series of evidence statements from the IOC expert committee on exercise and pregnancy in recreational and elite athletes. Part 1 focused on the effects of training during pregnancy and on the management of common pregnancy-related symptoms experienced by athletes. In Part 2, we focus on maternal and fetal perinatal outcomes.
Barriers To Recruiting Men Into Chronic Disease Prevention And Management Programs In Rural Areas: Perspectives Of Program Delivery Staff, Adam G. Gavarkovs, Shauna M. Burke, Kristen C. Reilly, Robert J. Petrella
Barriers To Recruiting Men Into Chronic Disease Prevention And Management Programs In Rural Areas: Perspectives Of Program Delivery Staff, Adam G. Gavarkovs, Shauna M. Burke, Kristen C. Reilly, Robert J. Petrella
Paediatrics Publications
Chronic disease is becoming increasingly prevalent in Canada. Many of these diseases could be prevented by adoption of healthy lifestyle habits including physical activity and healthy eating. Men, especially those in rural areas, are disproportionately affected by chronic disease. However, men are often underrepresented in community-based chronic disease prevention and management (CDPM) programs, including those that focus on physical activity and/or healthy eating. The purpose of this study was to explore the experiences and perceptions of program delivery staff regarding the challenges in recruitment and participation of men in physical activity and healthy eating programs in rural communities, and suggestions …
Engaging Men In Chronic Disease Prevention And Management Programs: A Scoping Review, Adam Gregory Gavarkovs, Shauna M. Burke, Robert J. Petrella
Engaging Men In Chronic Disease Prevention And Management Programs: A Scoping Review, Adam Gregory Gavarkovs, Shauna M. Burke, Robert J. Petrella
Paediatrics Publications
Chronic disease has become one of the largest health burdens facing the developed world. Men are at a higher risk of being diagnosed with chronic disease than women. Although lifestyle interventions have been shown to reduce the risk of chronic disease in participants, men are often underrepresented in such programs. The purpose of this study was to explore the individual-level and program-specific factors that affect male participation rates in chronic disease prevention and management (CDPM) programs. A scoping review methodology was selected, and 25 studies met the criteria for inclusion in the review. Results showed that traditional group-based programs that …
Renal Ganglioneuromas In A Pediatric Patient: Case Report And Review Of The Literature, Andrew Williams, Allison Osmond, Fahd Al Sufiani, Aaron R. Haig, Nancy G. Chan, Andreana Bütter
Renal Ganglioneuromas In A Pediatric Patient: Case Report And Review Of The Literature, Andrew Williams, Allison Osmond, Fahd Al Sufiani, Aaron R. Haig, Nancy G. Chan, Andreana Bütter
Paediatrics Publications
Ganglioneuromas are rare benign tumors originating from the sympathetic nervous system and neural crest cells. A 4-year-old girl presented with numerous urinary tract infections. Ultrasound and computed tomography revealed a large mass within the right kidney. A right nephrectomy and sampling of surrounding lymph nodes were performed. Pathology confirmed that the mass was a mature ganglioneuroma. The patient remains disease-free, more than 2 years after surgery. We present this rare case of renal ganglioneuroma as well as a review of the literature.
Averting The Foul Taste Of Pediatric Medicines Improves Adherence And Can Be Lifesaving - Pheburane® (Sodium Phenylbutyrate), Gideon Koren, Michael J. Rieder, Yona Amitai
Averting The Foul Taste Of Pediatric Medicines Improves Adherence And Can Be Lifesaving - Pheburane® (Sodium Phenylbutyrate), Gideon Koren, Michael J. Rieder, Yona Amitai
Paediatrics Publications
Background: Children’s aversions to poor and mostly bitter tastes and their inability to swallow tablets and capsules are major challenges in pediatric medicine. Sodium phenylbutyrate (NaPB) is a lifesaving waste nitrogen, alternative to urea nitrogen, for individuals suffering from urea cycle disorders. A major issue in the use of NaPB is its highly foul taste, which often leads to children being unable to consume it, resulting in ineffective treatment, or alternatively, necessitating the application of the drug through a nasogastric tube or gastrostomy. Methods: This study reviews the published data on a novel formulation of NaPB, Pheburane® granules, which begin …
Less Is More: Low Expression Of Mt1-Mmp Is Optimal To Promote Migration And Tumourigenesis Of Breast Cancer Cells, Mario A. Cepeda, Jacob J.H. Pelling, Caitlin L. Evered, Karla C. Williams, Zoey Freedman, Ioana Stan, Jessica A. Willson, Hon S. Leong, Sashko Damjanovski
Less Is More: Low Expression Of Mt1-Mmp Is Optimal To Promote Migration And Tumourigenesis Of Breast Cancer Cells, Mario A. Cepeda, Jacob J.H. Pelling, Caitlin L. Evered, Karla C. Williams, Zoey Freedman, Ioana Stan, Jessica A. Willson, Hon S. Leong, Sashko Damjanovski
Paediatrics Publications
Background: Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) is a multifunctional protease implicated in metastatic progression ostensibly due to its ability to degrade extracellular matrix (ECM) components and allow migration of cells through the basement membrane. Despite in vitro studies demonstrating this principle, this knowledge has not translated into the use of MMP inhibitors (MMPi) as effective cancer therapeutics, or been corroborated by evidence of in vivo ECM degradation mediated by MT1-MMP, suggesting that our understanding of the role of MT1-MMP in cancer progression is incomplete. Methods: MCF-7 and MDA-MB 231 breast cancer cell lines were created that stably overexpress different levels …
A Four-Month-Old Boy With Bilateral Undescended Testes, Sumit Dave
A Four-Month-Old Boy With Bilateral Undescended Testes, Sumit Dave
Paediatrics Publications
No abstract provided.
Macrophage-Derived Extracellular Vesicle-Packaged Wnts Rescue Intestinal Stem Cells And Enhance Survival After Radiation Injury, Subhrajit Saha, Evelyn Aranda, Yoku Hayakawa, Payel Bhanja, Safinur Atay, N. Patrik Brodin, Jiufeng Li, Samuel Asfaha, Laibin Liu, Yagnesh Tailor, Jinghang Zhang, Andrew K. Godwin, Wolfgang A. Tome, Timothy C. Wang, Chandan Guha, Jeffrey W. Pollard
Macrophage-Derived Extracellular Vesicle-Packaged Wnts Rescue Intestinal Stem Cells And Enhance Survival After Radiation Injury, Subhrajit Saha, Evelyn Aranda, Yoku Hayakawa, Payel Bhanja, Safinur Atay, N. Patrik Brodin, Jiufeng Li, Samuel Asfaha, Laibin Liu, Yagnesh Tailor, Jinghang Zhang, Andrew K. Godwin, Wolfgang A. Tome, Timothy C. Wang, Chandan Guha, Jeffrey W. Pollard
Paediatrics Publications
WNT/β-catenin signalling is crucial for intestinal homoeostasis. The intestinal epithelium and stroma are the major source of WNT ligands but their origin and role in intestinal stem cell (ISC) and epithelial repair remains unknown. Macrophages are a major constituent of the intestinal stroma. Here, we analyse the role of macrophage-derived WNT in intestinal repair in mice by inhibiting their release using a macrophage-restricted ablation of Porcupine, a gene essential for WNT synthesis. Such Porcn-depleted mice have normal intestinal morphology but are hypersensitive to radiation injury in the intestine compared with wild-type (WT) littermates. Porcn-null mice are rescued from radiation lethality …