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Western University

Neuroscience Institute Publications

Series

2022

Memory

Articles 1 - 3 of 3

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Cognitive Composites For Genetic Frontotemporal Dementia: Genfi-Cog, Jackie M. Poos, Katrina M. Moore, Jennifer Nicholas, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Lize C. Jiskoot, Emma Van Der Ende, Esther Van Den Berg, Janne M. Papma, Harro Seelaar, Yolande A.L. Pijnenburg, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre De Mendonça, Pietro Tiraboschi, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard Dec 2022

Cognitive Composites For Genetic Frontotemporal Dementia: Genfi-Cog, Jackie M. Poos, Katrina M. Moore, Jennifer Nicholas, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Lize C. Jiskoot, Emma Van Der Ende, Esther Van Den Berg, Janne M. Papma, Harro Seelaar, Yolande A.L. Pijnenburg, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre De Mendonça, Pietro Tiraboschi, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard

Neuroscience Institute Publications

Background: Clinical endpoints for upcoming therapeutic trials in frontotemporal dementia (FTD) are increasingly urgent. Cognitive composite scores are often used as endpoints but are lacking in genetic FTD. We aimed to create cognitive composite scores for genetic frontotemporal dementia (FTD) as well as recommendations for recruitment and duration in clinical trial design. Methods: A standardized neuropsychological test battery covering six cognitive domains was completed by 69 C9orf72, 41 GRN, and 28 MAPT mutation carriers with CDR® plus NACC-FTLD ≥ 0.5 and 275 controls. Logistic regression was used to identify the combination of tests that distinguished best between each mutation carrier …


Familiarity Modulates Neural Tracking Of Sung And Spoken Utterances, Christina M. Vanden Bosch Der Nederlanden, Marc F. Joanisse, Jessica A. Grahn, Tineke M. Snijders, Jan Mathijs Schoffelen May 2022

Familiarity Modulates Neural Tracking Of Sung And Spoken Utterances, Christina M. Vanden Bosch Der Nederlanden, Marc F. Joanisse, Jessica A. Grahn, Tineke M. Snijders, Jan Mathijs Schoffelen

Neuroscience Institute Publications

Music is often described in the laboratory and in the classroom as a beneficial tool for memory encoding and retention, with a particularly strong effect when words are sung to familiar compared to unfamiliar melodies. However, the neural mechanisms underlying this memory benefit, especially for benefits related to familiar music are not well understood. The current study examined whether neural tracking of the slow syllable rhythms of speech and song is modulated by melody familiarity. Participants became familiar with twelve novel melodies over four days prior to MEG testing. Neural tracking of the same utterances spoken and sung revealed greater …


Microglial Inflammation And Cognitive Dysfunction In Comorbid Rat Models Of Striatal Ischemic Stroke And Alzheimer's Disease: Effects Of Antioxidant Catalase-Skl On Behavioral And Cellular Pathology, Jennifer L. Mackenzie, Nadezda Ivanova, Hayley J. Nell, Courtney R. Giordano, Stanley R. Terlecky, Cansu Agca, Yuksel Agca, Paul A. Walton, Shawn N. Whitehead, David F. Cechetto Apr 2022

Microglial Inflammation And Cognitive Dysfunction In Comorbid Rat Models Of Striatal Ischemic Stroke And Alzheimer's Disease: Effects Of Antioxidant Catalase-Skl On Behavioral And Cellular Pathology, Jennifer L. Mackenzie, Nadezda Ivanova, Hayley J. Nell, Courtney R. Giordano, Stanley R. Terlecky, Cansu Agca, Yuksel Agca, Paul A. Walton, Shawn N. Whitehead, David F. Cechetto

Neuroscience Institute Publications

Ischemic stroke often co-occurs with Alzheimer's disease (AD) leading to a worsened clinical outcome. Neuroinflammation is a critical process implicated in AD and ischemic pathology, associated with cognitive decline. We sought to investigate the combined effects of ischemic stroke induced by endothelin-1 injection in two AD rat models, using motor function, memory and microglial inflammation in the basal forebrain and striatum as readouts. In addition, we sought to determine the effectiveness of the antioxidant biologic CAT-SKL in one of the models. The early AD model employed the bilateral intracerebroventricular injections of the toxic β-amyloid peptide Aβ25–35, the prodromal AD model …