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Power Management Strategies For Islanded Microgrids, Hisham Mahmood Dec 2014

Power Management Strategies For Islanded Microgrids, Hisham Mahmood

Electronic Thesis and Dissertation Repository

The focus of this thesis is on developing power management strategies for islanded microgrids, at the primary and the secondary hierarchal control layers. At the Primary Control Layer, the main objective of the proposed strategies is to achieve decentralized power management of Photovoltaic (PV) and battery storage in islanded microgrids. In contrast to the common approach of controlling the PV unit as a current source, in the proposed strategies, the PV unit is controlled as a voltage source that follows a multi-segment adaptive power/frequency characteristic curve. The strategies are implemented locally at the units using multi-loop controllers without relying on …


Measures Of Acoustic Reflexes In Typically Developing Children And Children With Suspected Auditory Processing Disorder, Udit Saxena Dec 2014

Measures Of Acoustic Reflexes In Typically Developing Children And Children With Suspected Auditory Processing Disorder, Udit Saxena

Electronic Thesis and Dissertation Repository

A series of studies were conducted to examine the acoustic reflex in normal hearing adults, typically developing children and children with suspected auditory processing disorder (APD). Elevated acoustic reflex thresholds (ART) and shallower acoustic reflex growth functions (ARGF) were found in children with suspected APD in comparison to typically developing children and normal hearing adults. These effects were strongest in the crossed condition. There were no group differences for acoustic reflex latency (ARL) or acoustic reflex decay (ARD).

In all studies the children with suspected APD were divided into two groups based on the diagnosis made on the basis of …


Thématiques Dans Les Récits Des Enfants Cachés Dans L'Univers Catholique En France, Carmen P. Mccarron Dec 2014

Thématiques Dans Les Récits Des Enfants Cachés Dans L'Univers Catholique En France, Carmen P. Mccarron

Electronic Thesis and Dissertation Repository

Cette thèse examine des thématiques communes à une vingtaine de récits publiés en français par des enfants de la Shoah qui ont été cachés dans des familles et des institutions catholiques, surtout en France. La bibliographie étendue de l’Institut de recherche sur la littérature de l’Holocauste nous a donné la possibilité de rassembler et d’étudier ces textes en un corpus cohérent, pour la première fois. Nous lisons les récits dans une perspective pluridisciplinaire, tout en les situant selon l'histoire sociale, afin de relever les préoccupations centrales des enfants juifs lorsqu’ils prennent la décision délicate de partager leur histoire avec le …


Production And Applications Of Formaldehyde-Free Phenolic Resins Using 5-Hydroxymethylfurfural Derived From Glucose In-Situ, Yongsheng Zhang Dec 2014

Production And Applications Of Formaldehyde-Free Phenolic Resins Using 5-Hydroxymethylfurfural Derived From Glucose In-Situ, Yongsheng Zhang

Electronic Thesis and Dissertation Repository

The phenol-formaldehyde (PF) resin manufacturing industry is facing a growing challenge with respect to concerns over human health, due to the use of carcinogenic formaldehyde and sustainability due to the use of petroleum-based phenol in PF resin manufacture. Glucose and its derivative, 5-hydroxymethylfurfural (5-HMF), have proven to be potential substitutes for formaldehyde in the synthesis of phenolic novolac resins.

This thesis investigated a number of glucose and 5-HMF resin systems including the curing of phenol-glucose novolac resin (PG) with a bis-phenol-A type epoxy. The curing process was modeled according to the Sestak-Berggren equation (S, B) using Málek methods. This was …


The Production Of Unequal Vulnerability To Flood Hazards In Metro Vancouver, Canada, Greg S. Oulahen Dec 2014

The Production Of Unequal Vulnerability To Flood Hazards In Metro Vancouver, Canada, Greg S. Oulahen

Electronic Thesis and Dissertation Repository

Flood risk is a growing concern in Canada’s cities. Residents of these cities have differential risk according to their unique vulnerability and exposure to flood hazards. Factors related to societal structural forces, human agency, and place interact to produce vulnerability to hazards. Analysis of the factors that influence vulnerability will lead to a better understanding of how unequal vulnerability to hazards is produced among residents of a city. This dissertation investigates the factors that influence vulnerability to flood hazards in a Canadian coastal urban region, Metro Vancouver. It develops and applies a conceptual framework for looking across scales and across …


Wind And Thermal Effects On Ground Mounted Photovoltaic (Pv) Panels, Chowdhury Mohammad Jubayer Dec 2014

Wind And Thermal Effects On Ground Mounted Photovoltaic (Pv) Panels, Chowdhury Mohammad Jubayer

Electronic Thesis and Dissertation Repository

A combination of Computational Fluid Dynamics (CFD) simulations and wind tunnel experiments are carried out to investigate the effects of wind on the aerodynamic loading and heat transfer of a ground mounted stand-alone photovoltaic (PV) panel with tilt angle of 25o in open country atmospheric boundary layer. Several azimuthal wind directions are considered: Southern 0o, Southwest 45o, Northwest 135o and Northern 180o. Three dimensional Reynolds-Averaged Navier-Stokes (RANS) approaches with an unsteady solver using Shear Stress Transport (SST) k-ω turbulence closure are employed for the CFD simulations, whereas Particle Image Velocimetry (PIV) and …


Metabolic Correlates In Spinal Cord Compression Measured By Magnetic Resonance Spectroscopy In The Motor And Sensory Cortices, Sandy Goncalves Dec 2014

Metabolic Correlates In Spinal Cord Compression Measured By Magnetic Resonance Spectroscopy In The Motor And Sensory Cortices, Sandy Goncalves

Electronic Thesis and Dissertation Repository

Surgical outcome for patients suffering from cervical myelopathy (CM) is unpredictable with varying motor and sensory symptom recovery. Previous in-vivo magnetic resonance spectroscopy (MRS) studies of patients surgically treated for CM have demonstrated decreased N-acetylaspartate (NAA)/creatine levels in the motor cortex indicating reduced neuronal function. The goal of this thesis was to determine whether absolute NAA changes in the motor and sensory cortices mirror the pattern of motor and sensory functional change observed in patients post surgical treatment.

MRS data were acquired on a 3.0 Tesla Siemens MRI along with clinical outcome measures at baseline, 6-weeks and 6-months post-surgery. …


Hydrolytic Depolymerization Of Lignin For The Preparation Of Polyols And Rigid Polyurethane Foams, Nubla Mahmood Dec 2014

Hydrolytic Depolymerization Of Lignin For The Preparation Of Polyols And Rigid Polyurethane Foams, Nubla Mahmood

Electronic Thesis and Dissertation Repository

This doctoral study was aimed to produce bio-polyols from Kraft lignin (KL) and hydrolysis lignin (HL) via depolymerization and utilize the lignin-derived bio-polyols in the preparation of bio-based rigid polyurethane (BRPU) foams at high percentage of bio-contents (50-70 wt.%). This study demonstrated that depolymerization is a practical and effective approach to unleash the potential of utilization of lignin, of complex structures and low reactivity/functionality, for bioproducts and biomaterials.

Depolymerization of KL was realized in alkaline medium using water alone as a solvent or employing water-ethylene glycol (EG) mixture via a low pressure (psig) proprietary process, both effective for producing low …


Clyfford Still In The 1930s: The Formative Years Of A Leading Abstract Expressionist, Emma Richan Dec 2014

Clyfford Still In The 1930s: The Formative Years Of A Leading Abstract Expressionist, Emma Richan

Electronic Thesis and Dissertation Repository

In 2011, Clyfford Still’s painting 1949-A-No.1 sold for $61.7 million at Sotheby’s auction house. This painting was one of four up for auction by the artist that night, fetching a total of $114 million to build the Clyfford Still Museum in Denver to house his entire estate. Still was among the most celebrated and notorious of the Abstract Expressionists, receiving the highest praise from Mark Rothko, Jackson Pollock, and Clement Greenberg during his lifetime. Still’s legacy has faltered since his death in 1980. Until 2011, 95% of his life’s work was stored in a barn in Maryland, hidden from view. …


Using Worked-Out Examples Of Written Explanation For Writing-To-Learn In Evolutionary Biology, Amy M. Yu Dec 2014

Using Worked-Out Examples Of Written Explanation For Writing-To-Learn In Evolutionary Biology, Amy M. Yu

Electronic Thesis and Dissertation Repository

Content learning can be enhanced through writing-to-learn. Research into cognitive load theory suggests that the use of backwards faded, worked-out examples increases schema acquisition and concept transfer. However, these effects have not yet been demonstrated for writing-to-learn, particularly for the conceptual understanding of evolution. The effects of two writing conditions were investigated in a pre-test post-test quasi-experimental design. Groups in two conditions wrote explanations of evolution using six Darwinian principles: students in the completion condition completed backwards faded, worked-out examples of explanations; students in the problem solving condition wrote full explanations, thought to require means-end problem solving. The dependent variables …


The Lunches Study: Elementary School Children's Packed Lunch Contents And Intake In The Traditional Vs. Balanced School Day Schedule, Lisa Neilson Dec 2014

The Lunches Study: Elementary School Children's Packed Lunch Contents And Intake In The Traditional Vs. Balanced School Day Schedule, Lisa Neilson

Electronic Thesis and Dissertation Repository

The Balanced School Day (BSD), an alternative to the Traditional Schedule (TS), provides two 20-minute eating periods during the school day, rather than a midday lunch break. Widespread implementation of the BSD schedule has occurred across Ontario with limited systematic evaluation of potential health outcomes. The purpose of this study was to compare the food and nutrient value of grade 3 and 4 students’ packed lunch contents and consumption in the BSD versus TS, by direct observation. When compared to the TS, more BSD students had a sugar-sweetened beverage packed in their lunch. Greater portions of snack items were also …


Mouse Models Of Intervertebral Disc Development, Degeneration And Mechanical Loading, Matthew R. Mccann Dec 2014

Mouse Models Of Intervertebral Disc Development, Degeneration And Mechanical Loading, Matthew R. Mccann

Electronic Thesis and Dissertation Repository

Intervertebral disc (IVD) degeneration is a complex and multi-factorial process that is influenced by aging, genetic predispositions and environmental influences, such as altered mechanical loading. While recent studies have begun to characterize changes in the IVD associated with degeneration, the underlying etiology remains elusive. It is thought that the loss of notochord cells from the nucleus pulposus (NP) is one initiating factor contributing to the cascade of disc degeneration. However, questions remain about the function of notochord cells within the disc, including their capacity as tissue specific progenitor cells for the nucleus pulposus. We have demonstrated, with the use of …


The Role Of Islands In The Migration Of Bats Across Lake Erie And Lake Ontario: Lasiurus Borealis, Lasiurus Cinereus And Perimyotis Subflavus, Toby J. Thorne Dec 2014

The Role Of Islands In The Migration Of Bats Across Lake Erie And Lake Ontario: Lasiurus Borealis, Lasiurus Cinereus And Perimyotis Subflavus, Toby J. Thorne

Electronic Thesis and Dissertation Repository

Large bodies of water, such as the Great Lakes in North America, are potential barriers to migrating bats. Islands may be used as stopover sites by bats crossing the Great Lakes as stopover sites, or included in crossing routes to reduce the distance flown over open water. I predicted that stopover use by migrating bats would result in higher activity on Great Lakes islands during late-season migration than at mainland sites. I monitored acoustic activity at 11 sites across four locations in Ontario: Amherst and Pelee islands, Kingston and Pinery Provincial Park during the summer (June and July), and during …


Role Of Integrin-Linked Kinase In Epidermal Integrity And Barrier Function, Samar Sayedyahossein Dec 2014

Role Of Integrin-Linked Kinase In Epidermal Integrity And Barrier Function, Samar Sayedyahossein

Electronic Thesis and Dissertation Repository

Integrin-linked kinase (ILK) is a β integrin adaptor protein that translates extracellular stimuli to intracellular signaling events. ILK plays a role in actin cytoskeleton dynamics and cell adhesion. The structure and function of the epidermis is highly dependent on cell-cell adhesion and cell-basement membrane interactions. The mechanisms whereby ILK contributes to epidermal integrity are poorly understood. Using a mouse model of epidermis-restricted Ilk gene inactivation, I observed that ILK loss causes abnormal morphology and presence of intra-epidermal and epidermal-dermal microblisters in embryos as early as E17.5. ILK-deficient epidermis is also characterized by abnormal localization or/and absence of adherens junctions, tight …


The “Other” Athletes: Representations Of Disability In Canadian Print Media During The London 2012 Paralympic Games, Melinda A. Maika Dec 2014

The “Other” Athletes: Representations Of Disability In Canadian Print Media During The London 2012 Paralympic Games, Melinda A. Maika

Electronic Thesis and Dissertation Repository

In our highly mediated society, media culture plays a critical role in socialization and offers a conduit for the naturalization of ideas. By this reasoning, stories told by the media about Paralympic athletes have the potential to influence our understanding of disability. This study reveals the representation of Paralympic athletes in Canada’s two national newspapers The National Post and The Globe & Mail surrounding the London 2012 Paralympic Games. Eighty-eight articles were collected over a 40-day period from August 15, 2012 – September 23, 2012. A critical disability studies lens guided methods of media frames analysis. Results demonstrated that coverage …


An Examination Of Psychological Variables Influencing Perceptions Of The Self Among A Sample Of Female Exercise Initiates, Lisa Cooke Dec 2014

An Examination Of Psychological Variables Influencing Perceptions Of The Self Among A Sample Of Female Exercise Initiates, Lisa Cooke

Electronic Thesis and Dissertation Repository

The general purpose of this dissertation was to explore the relationship among and within cognitive variables associated with exercise initiation and maintenance in a sample of female exercise initiates.

Manuscript 1 was structured to explore the changes to exercise identity among a population of female exercise initiates (N = 78) grouped into an imagery or control condition. Previous research has found that a strong exercise identity is associated with more frequent exercise (Strachan et al., 2009) and increases over time as a person continues to exercise (Cardinal & Cardinal, 1997). Participants were assessed multiple times (weeks 0, 5, 9, …


The Effects Of Dissolution On The Silicon And Oxygen Isotope Compositions Of Silica Phytoliths, Andrea Prentice Dec 2014

The Effects Of Dissolution On The Silicon And Oxygen Isotope Compositions Of Silica Phytoliths, Andrea Prentice

Electronic Thesis and Dissertation Repository

The δ30Si and δ18O values of silica phytoliths have applications for reconstructing paleoenvironmental conditions. This study examines the effect of partial dissolution and burning of phytoliths on their isotopic compositions, dissolution behaviour, and physical characteristics (specific surface area, mean particle size, and visual appearance) and discusses problems with the use of phytolith δ18O and δ30Si values that have been modified in soils in paleoclimate reconstruction. Dissolution experiments were conducted in batch reactors under a range of pH (4-10) and temperature (4-44˚C) conditions. The δ18O and δ30Si values of …


On The Application Of Mechanical Vibration In Robotics-Assisted Soft Tissue Intervention, Iman Khalaji Dec 2014

On The Application Of Mechanical Vibration In Robotics-Assisted Soft Tissue Intervention, Iman Khalaji

Electronic Thesis and Dissertation Repository

Mechanical vibration as a way of transmitting energy has been an interesting subject to study. While cyclic oscillation is usually associated with fatigue effect, and hence a detrimental factor in failure of structures and machineries, by controlled transmission of vibration, energy can be transferred from the source to the target. In this thesis, the application of such mechanical vibration in a few surgical procedures is demonstrated.

Three challenges associated with lung cancer diagnosis and treatment are chosen for this purpose, namely, Motion Compensation, tumor targeting in lung Needle Insertion and Soft Tissue Dissection:

  1. A robotic solution is proposed …


A New Generation Of Polymer/Ceramic Composite Biomaterials For Bone Regeneration, Mehrnaz Salarian Dec 2014

A New Generation Of Polymer/Ceramic Composite Biomaterials For Bone Regeneration, Mehrnaz Salarian

Electronic Thesis and Dissertation Repository

There is a substantial emerging interest for fundamental and applied research on the reinforcement of polymeric materials using nanotechnology. In the biomedical industry, development of novel bone cement composite materials with enhanced mechanical properties is of tremendous potential importance. The most universally used injectable bone cement is made of poly(methyl methacrylate) (PMMA); however, the major disadvantage of PMMA is its non-biodegradability. Polymers such as poly(propylene fumarate) (PPF) and polycaprolactone (PCL) are biodegradable, but suffer from a lack of mechanical properties. The aim of this research was to test the efficacy of these biodegradable polymers integrating nanotechnology for the development of …


Fatal Attraction: The Fetishized Image Of The Fatal Woman As Gothic Double, Margaret Anne Young Dec 2014

Fatal Attraction: The Fetishized Image Of The Fatal Woman As Gothic Double, Margaret Anne Young

Electronic Thesis and Dissertation Repository

The Gothic heroine is often doubled by an image – a painting, statue, costume, drawing, projection, or mental image – that is preternaturally powerful and endowed with an antagonistic sexual presence. This image of the fatal woman, unlike portraits of the heroine, is a representation without a referent: a fetish object, both for fictional characters and critics.

I argue that the simulacrum of dangerous femininity is a shifting signifier rather than a one-dimensional representation of – as previous critics have argued – ‘male fears and desires’ or female empowerment. Following the work of sociologist Bruno Latour and narratologist Mieke Bal, …


Topographic Controls On N2o And N2 Efflux In A Temperate Forest, Eric M. Enanga Dec 2014

Topographic Controls On N2o And N2 Efflux In A Temperate Forest, Eric M. Enanga

Electronic Thesis and Dissertation Repository

The release of greenhouse gases into the atmosphere is becoming an increasingly important problem due to the overwhelming evidence of the relationship between rising greenhouse gas concentrations and increased global temperatures. It is important that we gain a better understanding of the processes controlling the release of N2O, a powerful greenhouse gas. Topographic influences on soil temperature, moisture, reduction-oxidation (redox) potential, dissolved organic carbon, and nitrate conditions, which in turn influence N2O release, were investigated in a natural temperate forest ecosystem in Ontario, Canada. Wetland positions were observed to have the conditions most suited for N …


Digestion Of Municipal Wastewater Biosolids Using An Anaerobic Fluidized Bed Bioreactor (Anfbr), Zhenqi Wang Dec 2014

Digestion Of Municipal Wastewater Biosolids Using An Anaerobic Fluidized Bed Bioreactor (Anfbr), Zhenqi Wang

Electronic Thesis and Dissertation Repository

This research investigated the efficacy of the anaerobic fluidized bed bioreactor (AnFBR) technology in treating municipal wastewater sludges. Primary sludge (PS) and thickened waste activated sludge (TWAS) were studied in two lab-scale AnFBRs using High-density polyethylene (HDPE) as carrier media. PS was investigated at various organic loading rates (OLRs) ranging from 9 to 18 kg chemical oxygen demand (COD)/m3-d corresponding to hydraulic retention times (HRTs) of 2 to 4 days, with maximum COD and volatile suspended solid (VSS) removal efficiency of 70% and 72%, respectively. For TWAS, VSS destruction efficiency varied from 53% at an HRT of 4 …


Thylakoid Phosphorylation And Cell Morphology In The Antarctic Psychrophile, Chlamydomonas Sp. Uwo241, Beth Szyszka-Mroz Dec 2014

Thylakoid Phosphorylation And Cell Morphology In The Antarctic Psychrophile, Chlamydomonas Sp. Uwo241, Beth Szyszka-Mroz

Electronic Thesis and Dissertation Repository

The unicellular green microalga, Chlamydomonas sp. UWO 241, was isolated from Lake Bonney, Antarctica. A unique characteristic of this algal strain is its inability to undergo state transitions combined with an altered thylakoid protein phosphorylation profile, which suggests the absence of LHCII phosphorylation, and preferential phosphorylation of a set of novel proteins. Examination of the unique phosphoproteins revealed that they are associated with a large pigment-protein supercomplex, which contains components of both photosystem I and the cytochrome b6/f complex and likely functions in cyclic electron flow (CEF).

The absence of phosphorylation of LHCII proteins, associated with state …


Environmental Health Effects Of Multiple Exposures: Systemic Risks And The Detroit River International Crossing Study, Tor H. Oiamo Dec 2014

Environmental Health Effects Of Multiple Exposures: Systemic Risks And The Detroit River International Crossing Study, Tor H. Oiamo

Electronic Thesis and Dissertation Repository

This thesis examines cumulative exposures to traffic noise and outdoor air pollution on environmental and health related quality of life in Windsor, Ontario, and provides a critical analysis of the environmental assessment process for the Detroit River International Crossing (DRIC) Study. The research utilizes a systemic risk framework to understand environmental health and stress effects of cumulative exposures. The significance of this research is based on a relative absence of literature on the systemic health risks of cumulative exposures and the need to elucidate environmental annoyance as a health outcome for risk assessment. The objectives of the research were to …


Scale-Up Methodology For Bench-Scale Slurry Photocatalytic Reactors Using Combined Irradiation And Kinetic Modelling, Patricio J. Valades Pelayo Dec 2014

Scale-Up Methodology For Bench-Scale Slurry Photocatalytic Reactors Using Combined Irradiation And Kinetic Modelling, Patricio J. Valades Pelayo

Electronic Thesis and Dissertation Repository

The present study focuses on developing a predictive methodology to scale-up a slurry annular photoreactor using a TiO2 Degussa P25 from the bench-scale to a pilot-plant scale. The bench-scale photoreactor is a Photo-CREC-Water II, a 2.65 L internally-irradiated slurry annular photocatalytic reactor. The pilot-plant scale photoreactor is a Photo-CREC Water Solar Simulator, a 9.8 L pilot-plant photoreactor, externally irradiated by eight lamps.

The adopted methodology allows the independent validation of radiative and kinetic models avoiding cross-correlation issues. The proposed approach involves two Monte Carlo methods, to model the Radiative Transfer Equation (RTE) inside each photoreactor. With this end, a …


Design Of A Haptic Interface For Medical Applications Using Magneto-Rheological Fluid Based Actuators, Nima Najmaei Dec 2014

Design Of A Haptic Interface For Medical Applications Using Magneto-Rheological Fluid Based Actuators, Nima Najmaei

Electronic Thesis and Dissertation Repository

This thesis reports on the design, construction, and evaluation of a prototype two degrees-of-freedom (DOF) haptic interface, which takes advantage of Magneto-Rheological Fluid (MRF) based clutches for actuation. Haptic information provides important cues in teleoperated systems and enables the user to feel the interaction with a remote or virtual environment during teleoperation. The two main objectives in designing a haptic interface are stability and transparency. Indeed, deficiencies in these factors in haptics-enabled telerobotic systems has the introduction of haptics in medical environments where safety and reliability are prime considerations. An actuator with poor dynamics, high inertia, large size, and heavy …


Sade Au Bûcher. Lire, Dire Et Penser La Transgression À La Lumière Des Supplices, Dominic Marion Dec 2014

Sade Au Bûcher. Lire, Dire Et Penser La Transgression À La Lumière Des Supplices, Dominic Marion

Electronic Thesis and Dissertation Repository

La problématique de cette thèse s’ancre dans un constat : après avoir scandalisé le public pendant deux siècles, la figure de Sade paraît aujourd'hui bien intégrée à la circulation des marchandises. Notre premier chapitre cherche à aborder ce renversement en fonction du contraste qui sépare la réception initiale de Sade à la fin du XVIIIe siècle de sa canonisation dans la prestigieuse collection « Bibliothèque de la Pléiade » à la fin du XXe siècle. Cette thèse se structure selon deux parcours diachroniques présentés l’un à la suite de l’autre. S’échelonnant sur les chapitres deux à cinq, le …


Rural Heterosexual Female Adolescents' Decision-Making About Sexual Intercourse And Pregnancy In Ontario, Paulina Ezer Dec 2014

Rural Heterosexual Female Adolescents' Decision-Making About Sexual Intercourse And Pregnancy In Ontario, Paulina Ezer

Electronic Thesis and Dissertation Repository

Rural areas in Ontario tend to have higher rates of adolescent pregnancy. A constructivist grounded theory methodology was used to gain an in-depth understanding of rural female adolescents’ decision-making process regarding sexual intercourse and their reproductive health, and how they view rural factors and circumstances influencing this process. The adolescent sexual decision-making process that emerged from the analysis involved prioritizing four influences that affect and are affected by the rural context: personal values and circumstances, family values and expectations, friends’ influences, and community influences. Findings will improve our understanding of how rural female adolescents make choices regarding their reproductive health. …


Beyond The Sports Page: Baseball, The Cuban Revolution, And Rochester, New York Newspapers, 1954-1960, Evan K. Nagel Dec 2014

Beyond The Sports Page: Baseball, The Cuban Revolution, And Rochester, New York Newspapers, 1954-1960, Evan K. Nagel

Electronic Thesis and Dissertation Repository

In the 1950s, the Caribbean island of Cuba underwent a series of emphatic and revolutionary changes, culminating in Fidel Castro's regime coming to power in early 1959. A year later, relations between the Cuban government and their American counterpart had deteriorated rapidly to the point of rhetoric, economic sanctions, and covert military actions. Yet, both nations laid claim to the same national pastime: the sport of baseball. Since the 1860s, America's game of choice had been played passionately by Cubans, helping facilitate their social assimilation into the U.S. economic sphere. There was arguably a cultural sporting bridge between the two …


Regulation Of Crfr1 And 5-Ht2ar By Pdz Domain-Containing Proteins Sap97 And Psd-95, Henry A. Dunn Dec 2014

Regulation Of Crfr1 And 5-Ht2ar By Pdz Domain-Containing Proteins Sap97 And Psd-95, Henry A. Dunn

Electronic Thesis and Dissertation Repository

Previous studies identified a crosstalk mechanism whereby CRFR1 sensitized 5-HT2AR-mediated signaling via interactions with PDZ domain-containing proteins: a mechanism that may underlie stress-induced anxiety and depression. This prompted an investigation into uncovering which PDZ domain-containing proteins could regulate the crosstalk between these two receptors, and how they could be regulated individually. In the current studies, a subset of PDZ domain-containing proteins were identified that may interact with CRFR1 and 5-HT2AR. The focus narrowed to two candidates previously implicated in psychiatric disease: SAP97 and PSD-95. We confirmed SAP97 and PSD-95 as interacting partners of CRFR1 in adult …