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Imaging Atherosclerosis With Hybrid [(18)F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging: What Leonardo Da Vinci Could Not See, Myra S. Cocker, Brian Mc Ardle, J. David Spence, Cheemun Lum, Robert R. Hammond, Deidre C. Ongaro, Matthew A. Mcdonald, Robert A. Dekemp, Jean Claude Tardif, Rob S.B. Beanlands Dec 2012

Imaging Atherosclerosis With Hybrid [(18)F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging: What Leonardo Da Vinci Could Not See, Myra S. Cocker, Brian Mc Ardle, J. David Spence, Cheemun Lum, Robert R. Hammond, Deidre C. Ongaro, Matthew A. Mcdonald, Robert A. Dekemp, Jean Claude Tardif, Rob S.B. Beanlands

Department of Medicine Publications

Prodigious efforts and landmark discoveries have led toward significant advances in our understanding of atherosclerosis. Despite significant efforts, atherosclerosis continues globally to be a leading cause of mortality and reduced quality of life. With surges in the prevalence of obesity and diabetes, atherosclerosis is expected to have an even more pronounced impact upon the global burden of disease. It is imperative to develop strategies for the early detection of disease. Positron emission tomography (PET) imaging utilizing [18F]fluorodeoxyglucose (FDG) may provide a non-invasive means of characterizing inflammatory activity within atherosclerotic plaque, thus serving as a surrogate biomarker for detecting vulnerable plaque. …


Letter To The Editor: The Ezetimibe 'Controversy' Is A Misunderstanding, John David Spence Dec 2012

Letter To The Editor: The Ezetimibe 'Controversy' Is A Misunderstanding, John David Spence

Department of Medicine Publications

No abstract provided.


Cholesterol Lowering, Nutrition And Stroke Prevention, J. David Spence Nov 2012

Cholesterol Lowering, Nutrition And Stroke Prevention, J. David Spence

Department of Medicine Publications

No abstract provided.


Pseudohypertension, J. David Spence May 2012

Pseudohypertension, J. David Spence

Department of Medicine Publications

No abstract provided.


Why The United States Center For Medicare And Medicaid Services (Cms) Should Not Extend Reimbursement Indications For Carotid Artery Angioplasty/Stenting, A. L. Abbott, M. A. Adelman, A. V. Alexandrov, H. J.M. Barnett, J. Beard, P. Bell, M. Björck, D. Blacker, C. J. Buckley, R. P. Cambria, A. J. Comerota, E. S. Connolly, A. H. Davies, H. H. Eckstein, R. Faruqi, G. Fraedrich, P. Gloviczki, G. J. Hankey, R. E. Harbaugh, E. Heldenberg, S. J. Kittner, T. J. Kleinig, D. P. Mikhailidis, W. S. Moore, R. Naylor, A. Nicolaides, K. I. Paraskevas, D. M. Pelz, J. W. Prichard Mar 2012

Why The United States Center For Medicare And Medicaid Services (Cms) Should Not Extend Reimbursement Indications For Carotid Artery Angioplasty/Stenting, A. L. Abbott, M. A. Adelman, A. V. Alexandrov, H. J.M. Barnett, J. Beard, P. Bell, M. Björck, D. Blacker, C. J. Buckley, R. P. Cambria, A. J. Comerota, E. S. Connolly, A. H. Davies, H. H. Eckstein, R. Faruqi, G. Fraedrich, P. Gloviczki, G. J. Hankey, R. E. Harbaugh, E. Heldenberg, S. J. Kittner, T. J. Kleinig, D. P. Mikhailidis, W. S. Moore, R. Naylor, A. Nicolaides, K. I. Paraskevas, D. M. Pelz, J. W. Prichard

Department of Medicine Publications

No abstract provided.


Premature Atherosclerosis Is Associated With Hypovitaminosis D And Angiotensin-Converting Enzyme Inhibitor Non-Use In Lupus Patients, Roneka L. Ravenell, Diane L. Kamen, J. David Spence, Bruce W. Hollis, Thomas J. Fleury, Michael G. Janech, Jonas S. Almeida, Stephanie R. Shaftman, Jim C. Oates Jan 2012

Premature Atherosclerosis Is Associated With Hypovitaminosis D And Angiotensin-Converting Enzyme Inhibitor Non-Use In Lupus Patients, Roneka L. Ravenell, Diane L. Kamen, J. David Spence, Bruce W. Hollis, Thomas J. Fleury, Michael G. Janech, Jonas S. Almeida, Stephanie R. Shaftman, Jim C. Oates

Department of Medicine Publications

The ultimate goal is to identify and target modifiable risk factors that will reduce major cardiovascular events in African American lupus patients. As a first step toward achieving this goal, this study was designed to explore risk factor models of preclinical atherosclerosis in a predominantly African American group of patients with systemic lupus erythematosus (SLE) using variables historically associated with endothelial function in nonlupus populations. Fifty-one subjects with SLE but without a history of clinical cardiovascular events were enrolled. At entry, a Framingham risk factor history and medication list were recorded. Sera and plasma samples were analyzed for lipids, lupus …