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Tip-Enhanced Raman Spectroscopy Of Amyloid Β At Neuronal Spines., Mohammadali Tabatabaei, Fabiana A Caetano, Farshid Pashee, Stephen S G Ferguson, François Lagugné-Labarthet
Tip-Enhanced Raman Spectroscopy Of Amyloid Β At Neuronal Spines., Mohammadali Tabatabaei, Fabiana A Caetano, Farshid Pashee, Stephen S G Ferguson, François Lagugné-Labarthet
Chemistry Publications
The early stages of Alzheimer's disease pathogenesis are thought to occur at the synapse level, since synapse loss can be directly correlated with memory dysfunction. Considerable evidence has suggested that amyloid beta (Aβ), a secreted proteolytic derivative of amyloid precursor protein, appears to be a critical factor in the early 'synaptic failure' that is observed in Alzheimer's disease pathogenesis. The identification of Aβ at neuronal spines with high spatial resolution and high surface specificity would facilitate unraveling the intricate effect of Aβ on synapse loss and its effect on neighboring neuronal connections. Here, tip-enhanced Raman spectroscopy was used to map …
Tip-Enhanced Raman Spectroscopy Of Amyloid Β At Neuronal Spines., Mohammadali Tabatabaei, Fabiana A Caetano, Farshid Pashee, Stephen S G Ferguson, François Lagugné-Labarthet
Tip-Enhanced Raman Spectroscopy Of Amyloid Β At Neuronal Spines., Mohammadali Tabatabaei, Fabiana A Caetano, Farshid Pashee, Stephen S G Ferguson, François Lagugné-Labarthet
Chemistry Publications
The early stages of Alzheimer's disease pathogenesis are thought to occur at the synapse level, since synapse loss can be directly correlated with memory dysfunction. Considerable evidence has suggested that amyloid beta (Aβ), a secreted proteolytic derivative of amyloid precursor protein, appears to be a critical factor in the early 'synaptic failure' that is observed in Alzheimer's disease pathogenesis. The identification of Aβ at neuronal spines with high spatial resolution and high surface specificity would facilitate unraveling the intricate effect of Aβ on synapse loss and its effect on neighboring neuronal connections. Here, tip-enhanced Raman spectroscopy was used to map …