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A Holistic Computational Approach To Boosting The Performance Of Protein Search Engines, Majdi Ahmad Mosa Maabreh
A Holistic Computational Approach To Boosting The Performance Of Protein Search Engines, Majdi Ahmad Mosa Maabreh
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Despite availability of several proteins search engines, due to the increasing amounts of MS/MS data and database sizes, more efficient data analysis and reduction methods are important. Improving accuracy and performance of protein identification is a main goal in the community of proteomic research. In this research, a holistic solution for improvement in search performance is developed.
Most current search engines apply the SEQUEST style of searching protein databases to define MS/MS spectra. SEQUEST involves three main phases: (i) Indexing the protein databases, (ii) Matching and Ranking the MS/MS spectra and (iii) Filtering the matches and reporting the final proteins. …