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Application Of A Three-Lever Drug Discrimination Method To Differentiate The Interoceptive Stimulus Effects Of 3, 4-Methylenedioxypyrovalerone And 4-Methylmethcathinone In Male Sprague-Dawley Rats, Trent Bullock
Masters Theses
Psychoactive “bath salts” represent a continuing drug abuse problem. The synthetic cathinones, 3, 4-methylenedioxypyrovalerone (MDPV) and 4-methylmethcathinone (4-MMC) are popular constituents of “bath salts” in the United States and the United Kingdom, respectively. Addiction to these substances has proven difficult to treat, possibly requiring targeted therapeutics. Drug discrimination is a preclinical assay that may aid in treatment development. Thus far, two-lever (drug vs no drug) discrimination studies have exhibited asymmetrical substitution patterns between 4-MMC and MDPV. Therefore, a three-lever discrimination method was employed in which 12 male Sprague-Dawley rats were trained to discriminate 0.5 mg/kg MDPV, 2.0 mg/kg 4-MMC, and …