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An Investigation Of Groundwater Flow In The Vicinity Of Patoka Dam, Indiana, Lee Anne Bledsoe

Masters Theses & Specialist Projects

Several dams throughout the United States have been built on karst terrains, where soluble limestone bedrock has been dissolved to form features such as caves, sinkholes, and underground rivers. In such karst regions, subsurface hydrology can play an integral role in the condition, operation, and safety of dams and should be considered during risk assessment. Patoka Dam, near Jasper, Indiana, is situated on a well-developed karst landscape/aquifer system, faces significant potential challenges, and recently underwent risk assessment. A groundwater flow investigation using multiple fluorescent tracer tests, analysis of water-table elevations, isopach mapping of the Glen Dean Limestone, and spring hydrograph …

Fused-Molecular Systems For Organic Light Emitting Diodes, Avinash Jami

Masters Theses & Specialist Projects

Organic light emitting diodes (OLEDs) are electronic devices made by sandwitching organic light emissive materials between two electrodes. When voltage is applied across the two conductors, a bright light is generated. The color of the emitting light depends on the band gap of the semiconducting material. The work described here focuses on designing and synthesizing narrow band gap molecular systems derived from fused-arene derivatives for producing organic blue light emitting diodes. Three molecular systems derived from anthracene, pyrene, and carbazole, were designed and synthesized. Two molecular systems of anthracen-9-ylmethyl anthracene-9- carboxylate and pyren-1-ylmethyl 4-bromobenzoate were synthesized through Steglich esterification reaction …

Distributed Approach For Peptide Identification, Naga V K Abhinav Vedanbhatla

Masters Theses & Specialist Projects

A crucial step in protein identification is peptide identification. The Peptide Spectrum Match (PSM) information set is enormous. Hence, it is a time-consuming procedure to work on a single machine. PSMs are situated by a cross connection, a factual score, or a probability that the match between the trial and speculative is right and original. This procedure takes quite a while to execute. So, there is demand for enhancement of the performance to handle extensive peptide information sets. Development of appropriate distributed frameworks are expected to lessen the processing time.

The designed framework uses a peptide handling algorithm named C-Ranker, …

Expression And Purification Of Unlabelled And Isotopically Labelled Human Fibroblast Growth Factor-1 And Its Receptor Relevance In Cancer Research, Oluwadamilola Filani

Masters Theses & Specialist Projects

Studies show that fibroblast growth factors (FGFs) control variety of cellular activities such as mitosis, cell differentiation, survival and angiogenesis. The FGF family consists of 23 different heparin-binding proteins. One of the most intensively studied members is human FGF-1 (hFGF-1) because of its critical role in the formation of blood vessels and cell proliferation in some types of cancer. The biological activities of FGFs are primarily mediated via interactions with fibroblast growth factor receptors (FGFR) and are a potent target in cancer. In this study, we report an efficient affinity column purification of hFGF-1 and the D2 domain of FGFR-2 …

A Sem Study Of Copper Corrosion In Bowling Green Supply Lines, Reema M. Alghamdi

Masters Theses & Specialist Projects

Recently, the rate of corrosion of copper water pipes in Bowling Green, Kentucky has unexpectedly accelerated. The specific reasons for this are unknown. Our aim is to elucidate the factors enhancing the corrosion and help understand the primary mechanisms of action. This will help in combating and reducing future corrosion incidents leading to pipe failure, thus reducing losses experienced when these pipes are replaced. This study seeks to explore the characteristics and factors involved. The scanning electron microscopy was used to obtain elemental composition, and images of both inside and outside of the corroded pipes. Strikingly, corrosion primarily occurred on …

Expectation Numbers Of Cyclic Groups, Miriam Mahannah El-Farrah

Masters Theses & Specialist Projects

When choosing k random elements from a group the kth expectation number is the expected size of the subgroup generated by those specific elements. The main purpose of this thesis is to study the asymptotic properties for the first and second expectation numbers of large cyclic groups. The first chapter introduces the kth expectation number. This formula allows us to determine the expected size of any group. Explicit examples and computations of the first and second expectation number are given in the second chapter. Here we show example of both cyclic and dihedral groups. In chapter three we discuss arithmetic …

Zero-Waste Planning At Higher Education Institutions: A Case Study Of Western Kentucky University, Kianoosh Ebrahimi

Masters Theses & Specialist Projects

Over the past two decades, the number of universities that pursue zero-waste strategies has steadily increased. However, more study is required on several interrelated factors, policy barriers, and infrastructural fundamentals, which each influence the efficiency of waste management structures (WM) at universities. In this work, the role of the aforementioned factors in implementing an efficient sustainable WM program at higher education institutions was investigated, using Western Kentucky University (WKU) as a case study. The objectives of this study were to identify and assess what type of WM strategies should be priorities for a university that may lack stringent WM infrastructure. …

A Ph Switchable Responsive Surface For The Trapping And Release Of A Hydrophobic Substance, Ali Esmail Karim

Masters Theses & Specialist Projects

Solid phase extraction is one of the most widely used techniques to trap and release compounds in a solution. A hydrophobic substance will stick efficiently to a hydrophobic surface (the “like dissolves like” principle). With an introduced response (i.e. pH change), a responsive surface can change from hydrophobic to hydrophilic, weakening the hydrophobic substance’s attraction and thus facilitate in an easy removal. A surface has been prepared having a terminal anthranilic acid (AA) moiety on silica gel particles, microscope slides, and TLC plates in three steps. First, a vinyl group was attached to the surface. Then, this vinyl group was …

An Apache Hadoop Framework For Large-Scale Peptide Identification, Harinivesh Donepudi

Masters Theses & Specialist Projects

Peptide identification is an essential step in protein identification, and Peptide Spectrum Match (PSM) data set is huge, which is a time consuming process to work on a single machine. In a typical run of the peptide identification method, PSMs are positioned by a cross correlation, a statistical score, or a likelihood that the match between the trial and hypothetical is correct and unique. This process takes a long time to execute, and there is a demand for an increase in performance to handle large peptide data sets. Development of distributed frameworks are needed to reduce the processing time, but …

A Mixed Methods Assessment Of The Development, Use, And Educational Effectiveness Of University Campus Sustainability Tours, Ellen R. Barringer

Masters Theses & Specialist Projects

Campus sustainability tours are available at dozens of colleges and universities across the United States. These tours are considered a vital tool in interpreting the environmental and sustainable aspects of a campus to educate the campus community. Minimal quantitative data have been collected regarding their development, use, and effectiveness. In order to develop a dataset regarding the use of campus sustainability tours, surveys and interviews were sent to universities with such tours to discuss use and methods of development. A campus-wide electronic survey was sent to the Western Kentucky University (WKU) main campus community to determine their experiences with the …

Evaluation Of Xanthan/Enzymatically Modified Guar Gum Mixtures In Oil-In-Water Emulsions, Pavan Kumar Chityala

Masters Theses & Specialist Projects

Oil-in-water emulsions have wide range of applications in food industry because of their structure-forming properties, and as delivery systems of polyunsaturated fatty acids into foods. The thermodynamic instability of oil and water, and high susceptibility of unsaturated fatty acids to oxidation lead to physical and oxidative stability in oil-in-water emulsions. These instability processes are generally controlled by incorporating proteins and polysaccharides into oil-in-water emulsions. The objective of this study was to evaluate xanthan/enzymatically modified guar (XG/EMG) polysaccharides on the physical and oxidative stability of 2 wt% whey protein stabilized oil-in-water emulsions containing 20% v/v menhaden fish oil. Enzymatic modified guar …

One-Step Synthesis Of Kanamycin Functionalized Gold Nanoparticles With Potent Antibacterial Activity Against Resistant Bacterial Strains, Hitesh Kumar Waghwani

Masters Theses & Specialist Projects

On the verge of entering the post-antibiotic era, numerous efforts are in place to regain the losing potential of antibiotics which are proving ineffective against common bacterial infections. Engineered nanomaterials, especially gold nanoparticles (GNPs) capped with antibacterial agents are proving to be an effective and novel strategy against multi-drug resistant (MDR) bacteria. In this study, we report a one-step synthesis of kanamycin-capped GNPs (20 ± 5 nm) utilizing the combined reducing and capping ability of the aminoglycoside antibiotic, kanamycin. Antibacterial assays showed dosedependent broad spectrum activity of Kan-GNPs against Gram-positive (Staphylococcus epidermidis and Enterococcus durans), Gram-negative (Escherichia coli and Enterobacter …

Study Of Mechanical Properties Of Pva Fiber-Reinforced Concrete With Raman Spectroscopic Analysis, Ramyasree Annam

Masters Theses & Specialist Projects

The brittleness of concrete has always been a safety and economic issue of great concern. The low tensile strength of concrete is the cause of its intrinsic brittle nature. This is critical considering the amount of concrete used for the construction of highways, buildings, and other facilities. The mechanical properties of concrete must be improved to provide upgraded construction. Crack resistant and durable concrete has always been a major goal for engineers. Many approaches have been tried to make concrete a better construction material. Fiber reinforcement is an approach which has been shown to improve the quality and durability of …

Fused Arene-Based Molecular Systems As Additives For Organic Photovoltaics, Rachana Neesu

Masters Theses & Specialist Projects

Organic photovoltaics (OPVs) are mainly based on organic semiconducting small molecules, macromolecules, and polymers, which form an active layer in photovoltaics. They act as an active material in absorbing light and causing charge mobility to generate electricity from sunlight. This thesis describes the molecular systems derived from fused arenes such as anthracene, pyrene, carbazole and thiophene for use as either a donor or an acceptor component of the active layer of OPVs. Two novel molecular systems (9- anthracenecarboxy-1-methylpyrene, (1) and Py-bi-TH-ANT, (2) were prepared using Steglich esterification and Grignard metathesis followed by Kumada coupling. The molecular structure of each was …

Surface Microstructure Evolution Of Metallic Specimens Using The Large Chamber Scanning Electron Microscope, Grace Egbujor

Masters Theses & Specialist Projects

An initial study into the use of the large chamber scanning electron microscope (LCSEM) to interrogate the surface microstructure evolution of metallic specimens has been carried out. The LC-SEM located at Western Kentucky University is the largest instrument of its type at any university in the world. As such, unique measurements can be performed due to the size of its chamber and extended view of its optic system. Strain was varied for each individual specimen, and imaged using Secondary Electrons within the gauge length as well as near the grip position. Results will show progression of surface microstructures and nickel …

Thiophene And Derivatives For Use In Pyridazines And Thiapentalenes, Benjamin Tyree Cannon

Masters Theses & Specialist Projects

This thesis introduces the idea of Band Theory and how it can be used to describe a solid-state materials ability to carry an electrical charge. Next, this thesis defines what makes a material a conductor, semiconductor, or insulator. Semiconductors are attracting interest in chemistry, as well as in the manufacturing of consumer electronics, because of their ability to carry a charge, without the risk of short-circuiting like traditional conductors.1,4 Organic semiconductors, which behave differently than traditional semiconductors, are of particular interest because they offer mechanical flexibility, lowcost, simplicity, and the ability to be manufactures at low temperatures.6 Nonorganic and organic …

Moneyware: Simulating Software Portfolio Quality Management, Robert David Beverly

Masters Theses & Specialist Projects

In this research we introduce MoneyWare, a simulator designed to explore and ultimately to provide guidance on simulating software portfolio quality management. The name “MoneyWare” is inspired by the movie Moneyball. It chronicled a baseball team which used more descriptive statistics to achieve a higher quality ball club with limited resources. MoneyWare is inspired by the observation that the problem of software development is somewhat analogous. Management is faced with an incoming stream of tasks for development. The tasks vary in terms of size, priority, risk, and date needed. But, in any case, the demands come to more than the …

Generating Random Walks And Polygons With Thickness In Confinement, Sai Sindhuja Veeramachaneni

Masters Theses & Specialist Projects

Algorithms to generate walks (chains of unit-length, freely-jointed segments) and polygons (closed walks) in spherical confinements have been developed in the last few years. These algorithms generate polygons inside spherical confinement based on their mathematically derived probability distributions. The generated polygons do not occupy any volume { although that would be useful for some applications. This thesis investigates how to generate walks and polygons which occupy some volume in spherical confinement. More specifically, in this thesis, existing methods described in the literature have been studied and implemented to generate walks and polygons in confinement. Additionally, these methods were adapted to …

Counting Convex Sets On Products Of Totally Ordered Sets, Brandy Amanda Barnette

Masters Theses & Specialist Projects

The main purpose of this thesis is to find the number of convex sets on a product of two totally ordered spaces. We will give formulas to find this number for specific cases and describe a process to obtain this number for all such spaces. In the first chapter we briefly discuss the motivation behind the work presented in this thesis. Also, the definitions and notation used throughout the paper are introduced here The second chapter starts with examining the product spaces of the form {1; 2; : : : ;n} × {1; 2}. That is, we begin by analyzing …

Corrosion Behaviors Of Coated Aluminum Alloys In Simulated Corrosive Environment, Jingyi Yue

Masters Theses & Specialist Projects

This study investigated the corrosion of an aluminum alloy with and without coatings under simulated corrosive environments. Coatings were selected and applied from commercial materials and techniques, consisting of microceramic, epoxy primer, and topcoat. The experiments for coated specimens were carried out under various corrosive conditions, specifically, hydrodynamic flow, immersion in salt water and DI water, varying temperatures, and simulated sun light. The hydrodynamic conditions were simulated using a rotating cylinder electrode (RCE) with rotational speeds of 200, 400, 600, 800, and 1000 rpm. The immersion in saltwater and sunlight illumination tests were applied for 8 hours, and the simulated …

Analysis Of Discrete Fractional Operators And Discrete Fractional Rheological Models, Meltem Uyanik

Masters Theses & Specialist Projects

This thesis is comprised of two main parts: Monotonicity results on discrete fractional operators and discrete fractional rheological constitutive equations. In the first part of the thesis, we introduce and prove new monotonicity concepts in discrete fractional calculus. In the remainder, we carry previous results about fractional rheological models to the discrete fractional case. The discrete method is expected to provide a better understanding of the concept than the continuous case as this has been the case in the past. In the first chapter, we give brief information about the main results. In the second chapter, we present some fundamental …

Understanding The Molecular Level Interactions Of Cancer Inhibitor Imatinib With Human Fibroblast Growth Factor-1, Tulsi Modi

Masters Theses & Specialist Projects

Fibroblast growth factors (FGFs) lack signal sequences, and are exported through endoplasmic reticulum (ER)-Golgi-independent non-classical routes. FGFs work as modulators of various cellular activities like mitosis, differentiation, survival etc. Among the FGF family, which comprises of 23 different heparin proteins, human FGF-1 (hFGF-1), a potent angiogenic factors are one of the targets in cancer inhibition, as they are involved in blood vessel formation in tissues. There has been intensive research directed at the development of drugs that could effectively inhibit angiogenesis. In this context, the purpose of this study is to fully understand the molecular principles essential to determine probability …

Application Of A Numerical Method And Optimal Control Theory To A Partial Differential Equation Model For A Bacterial Infection In A Chronic Wound, Stephen Guffey

Masters Theses & Specialist Projects

In this work, we study the application both of optimal control techniques and a numerical method to a system of partial differential equations arising from a problem in wound healing. Optimal control theory is a generalization of calculus of variations, as well as the method of Lagrange Multipliers. Both of these techniques have seen prevalent use in the modern theories of Physics, Economics, as well as in the study of Partial Differential Equations. The numerical method we consider is the method of lines, a prominent method for solving partial differential equations. This method uses finite difference schemes to discretize the …

Syntheses, Structures And Properties Of Metal-Organic Frameworks, Xin Liu

Masters Theses & Specialist Projects

Mercury is one of the most serious heavy metal pollution sources that threaten people’s health. For decades, people have developed many technologies and materials to capture mercury from flue gas of coal-fired plant. Currently, the most effective material for mercury absorption is powdered activated carbon, which shows increased efficiency when modified with halogen functional groups such as bromine. Metal-organic frameworks (MOFs) have potential applications in mercury capture due to their fantastic properties such as high porosity and high thermal stability. More important, their pore sizes and topology structures can be controlled through choosing different organic ligands in the syntheses. However, …

Boundary Problems For One And Two Dimensional Random Walks, Miky Wright

Masters Theses & Specialist Projects

This thesis provides a study of various boundary problems for one and two dimensional random walks. We first consider a one-dimensional random walk that starts at integer-valued height k > 0, with a lower boundary being the x-axis, and on each step moving downward with probability q being greater than or equal to the probability of going upward p. We derive the variance and the standard deviation of the number of steps T needed for the height to reach 0 from k, by first deriving the moment generating function of T. We then study two types of two-dimensional random walks with …