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Pilot Gwas Of Caries In African-Americans Shows Genetic Heterogeneity, E. Orlova, J. C. Carlson, M. K. Lee, E. Feingold, D. W. Mcneil, R. J. Crout, R. J. Weyant, M. L. Marazita, J. R. Shaffer
Pilot Gwas Of Caries In African-Americans Shows Genetic Heterogeneity, E. Orlova, J. C. Carlson, M. K. Lee, E. Feingold, D. W. Mcneil, R. J. Crout, R. J. Weyant, M. L. Marazita, J. R. Shaffer
Faculty & Staff Scholarship
Background
Dental caries is the most common chronic disease in the US and disproportionately affects racial/ethnic minorities. Caries is heritable, and though genetic heterogeneity exists between ancestries for a substantial portion of loci associated with complex disease, a genome-wide association study (GWAS) of caries specifically in African Americans has not been performed previously.
Methods
We performed exploratory GWAS of dental caries in 109 African American adults (age > 18) and 96 children (age 3–12) from the Center for Oral Health Research in Appalachia (COHRA1 cohort). Caries phenotypes (DMFS, DMFT, dft, and dfs indices) assessed by dental exams were tested for association …
Human Retinal Pigment Epithelial Cells Prefer Proline As A Nutrient And Transport Metabolic Intermediates To The Retinal Side, Jennifer R. Chao, Kaitlen Knight, Yekai Wang, Jianhai Du
Human Retinal Pigment Epithelial Cells Prefer Proline As A Nutrient And Transport Metabolic Intermediates To The Retinal Side, Jennifer R. Chao, Kaitlen Knight, Yekai Wang, Jianhai Du
Faculty & Staff Scholarship
No abstract provided.
Endoplasmic Reticulum Stress And Inflammation In The Central Nervous System, Neil T. Sprenkle, Savannah G. Sims, Cristina L. Sánchez, Gordon P. Meares
Endoplasmic Reticulum Stress And Inflammation In The Central Nervous System, Neil T. Sprenkle, Savannah G. Sims, Cristina L. Sánchez, Gordon P. Meares
Faculty & Staff Scholarship
Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate cell death. In neurodegenerative diseases, the accumulation of misfolded proteins and concomitant induction of ER stress in neurons contributes to neuronal dysfunction. In addition, ER stress responses induced in the surrounding neuroglia may promote disease progression by coordinating damaging inflammatory responses, which help fuel a neurotoxic milieu. Nevertheless, there still remains a gap in knowledge regarding the cell-specific mechanisms by which ER stress mediates neuroinflammation. In this review, we will discuss recently uncovered inflammatory …
Nebulized Heparin For Patients Under Mechanical Ventilation: An Individual Patient Data Meta-Analysis, Gerie J. Glas, Ary Serpa Neto, Janneke Horn, Amalia Cochran, Barry Dixon, Elamin M. Elamin, Iris Farklas, Sharmila Dissanaike, Andrew C. Miller, Marcus J. Schultz
Nebulized Heparin For Patients Under Mechanical Ventilation: An Individual Patient Data Meta-Analysis, Gerie J. Glas, Ary Serpa Neto, Janneke Horn, Amalia Cochran, Barry Dixon, Elamin M. Elamin, Iris Farklas, Sharmila Dissanaike, Andrew C. Miller, Marcus J. Schultz
Faculty & Staff Scholarship
Pulmonary coagulopathy is a characteristic feature of lung injury including ventilator-induced lung injury. The aim of this individual patient data meta-analysis is to assess the effects of nebulized anticoagulants on outcome of ventilated intensive care unit (ICU) patients. A systematic search of PubMed (1966–2014), Scopus, EMBASE, and Web of Science was conducted to identify relevant publications. Studies evaluating nebulization of anticoagulants in ventilated patients were screened for inclusion, and corresponding authors of included studies were contacted to provide individual patient data. The primary endpoint was the number of ventilator-free days and alive at day 28. Secondary endpoints included hospital mortality, …
Is Nutrient Intake Associated With Physical Activity Levels In Healthy Young Adults?, Yi Yan, Clemens Drenowatz, Gregory A Hand, Robin P Shook, Thomas G Hurley, James R Hebert, Steven N Blair
Is Nutrient Intake Associated With Physical Activity Levels In Healthy Young Adults?, Yi Yan, Clemens Drenowatz, Gregory A Hand, Robin P Shook, Thomas G Hurley, James R Hebert, Steven N Blair
Faculty & Staff Scholarship
Both physical activity (PA) and diet are important contributors to health and well-being; however, there is limited information on the association of these behaviours and whether observed associations differ by weight. The present study aimed to evaluate whether nutrient intake is associated with PA and if this association varies by weight in young adults. Cross-sectional study to analyse the association between PA and nutrient intake. Participants were stratified as normal weight (18·5 kg/m2 2) and overweight/obese (BMI≥25·0 kg/m2). PA level (PAL) was calculated (PAL=total daily energy expenditure/RMR) and used to stratify groups (PAL Adults (n 407; age 27·6 (sd 3·8) …
Surgical Procedure Characteristics And Risk Of Sharps-Related Blood And Body Fluid Exposure, Douglas J. Myers, Hester J. Lipscomb, Carol Epling, Debra Hunt, William Richardson, Lynn Smith-Lovin, John M. Dement
Surgical Procedure Characteristics And Risk Of Sharps-Related Blood And Body Fluid Exposure, Douglas J. Myers, Hester J. Lipscomb, Carol Epling, Debra Hunt, William Richardson, Lynn Smith-Lovin, John M. Dement
Faculty & Staff Scholarship
OBJECTIVE To use a unique multicomponent administrative data set assembled at a large academic teaching hospital to examine the risk of percutaneous blood and body fluid (BBF) exposures occurring in operating rooms. DESIGN A 10-year retrospective cohort design. SETTING A single large academic teaching hospital. PARTICIPANTS All surgical procedures (n=333,073) performed in 2001-2010 as well as 2,113 reported BBF exposures were analyzed. METHODS Crude exposure rates were calculated; Poisson regression was used to analyze risk factors and account for procedure duration. BBF exposures involving suture needles were examined separately from those involving other device types to examine possible differences in …
Sox9 Inhibits -Trcp-Mediated Protein Degradation To Promote Nuclear Gli1 Expression And Cancer Stem Cell Properties, W. Deng, D. B. Vanderbilt, C.-C. Lin, K. H. Martin, K. M. Brundage, J. M. Ruppert
Sox9 Inhibits -Trcp-Mediated Protein Degradation To Promote Nuclear Gli1 Expression And Cancer Stem Cell Properties, W. Deng, D. B. Vanderbilt, C.-C. Lin, K. H. Martin, K. M. Brundage, J. M. Ruppert
Faculty & Staff Scholarship
No abstract provided.
Differences In Breast-Feeding Initiation And Continuation By Maternal Diabetes Status, Reena Oza-Frank, Ilana Chertok, Adam Bartley
Differences In Breast-Feeding Initiation And Continuation By Maternal Diabetes Status, Reena Oza-Frank, Ilana Chertok, Adam Bartley
Faculty & Staff Scholarship
To examine (i) the prevalence of and associations between breast-feeding initiation and continuation by maternal diabetes status and (ii) the reasons for not initiating and/or continuing breast-feeding by maternal diabetes status. Secondary data analyses of a population-based cross-sectional study were conducting using data from the US Centers for Disease Control and Prevention's Pregnancy Risk Assessment Monitoring System (PRAMS), 2009-2011. Multivariable logistic regression was used to investigate the associations between breast-feeding initiation and continuation by diabetes status. Thirty states and New York City, USA. Mothers of recently live-born infants, selected by birth certificate sampling. Among 72755 women, 8.8 % had gestational …
Role Of Sigma-1 Receptors In Neurodegenerative Diseases, Linda Nguyen, Brandon P. Lucke-Wold, Shona A. Mookerjee, John Z. Cavendish, Matthew J. Robson, Anna L. Scandinaro, Rae R. Matsumoto
Role Of Sigma-1 Receptors In Neurodegenerative Diseases, Linda Nguyen, Brandon P. Lucke-Wold, Shona A. Mookerjee, John Z. Cavendish, Matthew J. Robson, Anna L. Scandinaro, Rae R. Matsumoto
Faculty & Staff Scholarship
Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes appear to share common mechanisms of neuronal cellular dysfunction, including excitotoxicity, calcium dysregulation, oxidative damage, ER stress and mitochondrial dysfunction. Glial cells, including microglia and astrocytes, play an increasingly recognized role in both the promotion and prevention of neurodegeneration. Sigma receptors, particularly the sigma-1 receptor subtype, which are expressed in both neurons and glia of multiple regions within the central nervous system, are a unique class of intracellular proteins that can modulate many biological mechanisms associated with neurodegeneration. These receptors therefore represent compelling putative targets for pharmacologically treating neurodegenerative disorders. In …
Association Of Ataxia Telangiectasia Mutated (Atm) Gene Mutation/Deletion With Rhabdomyosarcoma, Peilin Zhang, Kunjan S. Bhakta, Pier Lorenzo Puri, Robert Newbury, James Feramisco, Jean Wang
Association Of Ataxia Telangiectasia Mutated (Atm) Gene Mutation/Deletion With Rhabdomyosarcoma, Peilin Zhang, Kunjan S. Bhakta, Pier Lorenzo Puri, Robert Newbury, James Feramisco, Jean Wang
Faculty & Staff Scholarship
No abstract provided.
Effects Of Exercise On Bmi Z-Score In Overweight And Obese Children And Adolescents: A Systematic Review With Meta-Analysis, George A Kelley, Kristi S Kelley, Russell R Pate
Effects Of Exercise On Bmi Z-Score In Overweight And Obese Children And Adolescents: A Systematic Review With Meta-Analysis, George A Kelley, Kristi S Kelley, Russell R Pate
Faculty & Staff Scholarship
No abstract provided.
In-Depth Interviews With State Public Health Practitioners On The United States National Physical Activity Plan, Kelly R Evenson, Sara B Satinsky, Cheryl Valko, Jeanette Gustat, Isobel Healy, Jill S Litt, Steven P Hooker, Hannah L Reed, Nancy Tompkins
In-Depth Interviews With State Public Health Practitioners On The United States National Physical Activity Plan, Kelly R Evenson, Sara B Satinsky, Cheryl Valko, Jeanette Gustat, Isobel Healy, Jill S Litt, Steven P Hooker, Hannah L Reed, Nancy Tompkins
Faculty & Staff Scholarship
No abstract provided.
Depression, Anxiety, And Symptom Profiles Among Female And Male Victims Of Sexual Violence, Ekta Choudhary, Merideth Smith, Robert M. Bossarte
Depression, Anxiety, And Symptom Profiles Among Female And Male Victims Of Sexual Violence, Ekta Choudhary, Merideth Smith, Robert M. Bossarte
Faculty & Staff Scholarship
No abstract provided.
Src Binds Cortactin Through An Sh2 Domain Cystine-Mediated Linkage, J. V. Evans, A. G. Ammer, J. E. Jett, C. A. Bolcato, J. C. Breaux, K. H. Martin, M. V. Culp, P. M. Gannett, S. A. Weed
Src Binds Cortactin Through An Sh2 Domain Cystine-Mediated Linkage, J. V. Evans, A. G. Ammer, J. E. Jett, C. A. Bolcato, J. C. Breaux, K. H. Martin, M. V. Culp, P. M. Gannett, S. A. Weed
Faculty & Staff Scholarship
No abstract provided.
Forty Years Of Increasing Suicide Mortality In Poland: Undercounting Amidst A Hanging Epidemic?, Peter Höfer, Ian R H Rockett, Peeter Värnik, Elmar Etzersdorfer, Nestor D Kapusta
Forty Years Of Increasing Suicide Mortality In Poland: Undercounting Amidst A Hanging Epidemic?, Peter Höfer, Ian R H Rockett, Peeter Värnik, Elmar Etzersdorfer, Nestor D Kapusta
Faculty & Staff Scholarship
No abstract provided.
Cellular Functions Of Fak Kinases: Insight Into Molecular Mechanisms And Novel Functions, M. D. Schaller
Cellular Functions Of Fak Kinases: Insight Into Molecular Mechanisms And Novel Functions, M. D. Schaller
Faculty & Staff Scholarship
No abstract provided.
Myosin Light Chain Kinase Mediates Transcellular Intravasation Of Breast Cancer Cells Through The Underlying Endothelial Cells: A Three-Dimensional Fret Study, S. Khuon, L. Liang, R. W. Dettman, P. H. S. Sporn, R. B. Wysolmerski, T.-L. Chew
Myosin Light Chain Kinase Mediates Transcellular Intravasation Of Breast Cancer Cells Through The Underlying Endothelial Cells: A Three-Dimensional Fret Study, S. Khuon, L. Liang, R. W. Dettman, P. H. S. Sporn, R. B. Wysolmerski, T.-L. Chew
Faculty & Staff Scholarship
No abstract provided.
Association Between Serum Γ-Glutamyltransferase And Chronic Kidney Disease Among Us Adults, Srinivas Teppala, Anoop Shankar, Jialiang Li, Tien Yin Wong, Alan Ducatman
Association Between Serum Γ-Glutamyltransferase And Chronic Kidney Disease Among Us Adults, Srinivas Teppala, Anoop Shankar, Jialiang Li, Tien Yin Wong, Alan Ducatman
Faculty & Staff Scholarship
No abstract provided.
Oncogenic Src Requires A Wild-Type Counterpart To Regulate Invadopodia Maturation, L. C. Kelley, A. G. Ammer, K. E. Hayes, K. H. Martin, K. Machida, L. Jia, B. J. Mayer, S. A. Weed
Oncogenic Src Requires A Wild-Type Counterpart To Regulate Invadopodia Maturation, L. C. Kelley, A. G. Ammer, K. E. Hayes, K. H. Martin, K. Machida, L. Jia, B. J. Mayer, S. A. Weed
Faculty & Staff Scholarship
No abstract provided.
Fak, Pdz-Rhogef And Rockii Cooperate To Regulate Adhesion Movement And Trailing-Edge Retraction In Fibroblasts, M. P. Iwanicki, T. Vomastek, R. W. Tilghman, K. H. Martin, J. Banerjee, P. B. Wedegaertner, J. T. Parsons
Fak, Pdz-Rhogef And Rockii Cooperate To Regulate Adhesion Movement And Trailing-Edge Retraction In Fibroblasts, M. P. Iwanicki, T. Vomastek, R. W. Tilghman, K. H. Martin, J. Banerjee, P. B. Wedegaertner, J. T. Parsons
Faculty & Staff Scholarship
No abstract provided.
Collective Behavior Of Stabilized Reaction-Diffusion Waves, Aaron J. Steele, Mark Tinsley, Kenneth Showalter
Collective Behavior Of Stabilized Reaction-Diffusion Waves, Aaron J. Steele, Mark Tinsley, Kenneth Showalter
Faculty & Staff Scholarship
No abstract provided.
Cyanidin-3-Glucoside, A Natural Product Derived From Blackberry, Exhibits Chemopreventive And Chemotherapeutic Activity, Min Ding, Rentian Feng, Shiow Y. Wang, Linda Bowman, Yongju Lu, Yong Qian, Vincent Castranova, Bing-Hua Jiang, Xianglin Shi
Cyanidin-3-Glucoside, A Natural Product Derived From Blackberry, Exhibits Chemopreventive And Chemotherapeutic Activity, Min Ding, Rentian Feng, Shiow Y. Wang, Linda Bowman, Yongju Lu, Yong Qian, Vincent Castranova, Bing-Hua Jiang, Xianglin Shi
Faculty & Staff Scholarship
Epidemiological data suggest that consumption of fruits and vegetables has been associated with a lower incidence of cancer. Cyanidin-3-glucoside (C3G), a compound found in blackberry and other food products, was shown to possess chemopreventive and chemotherapeutic activity in the present study. In cultured JB6 cells, C3G was able to scavenge ultraviolet B-induced *OH and O2-* radicals. In vivo studies indicated that C3G treatment decreased the number of non-malignant and malignant skin tumors per mouse induced by 12-O-tetradecanolyphorbol-13-acetate (TPA) in 7,12-dimethylbenz[a]anthracene-initiated mouse skin. Pretreatment of JB6 cells with C3G inhibited UVB- and TPA-induced transactivation of NF-kappaB and AP-1 and expression of …
Spatiotemporal Dynamics Of Networks Of Excitable Nodes, Aaron J. Steele, Mark Tinsley, Kenneth Showalter
Spatiotemporal Dynamics Of Networks Of Excitable Nodes, Aaron J. Steele, Mark Tinsley, Kenneth Showalter
Faculty & Staff Scholarship
No abstract provided.
An Exonic Splicing Silencer Is Involved In The Regulated Splicing Of Glucose 6-Phosphate Dehydrogenase Mrna, Wioletta Szeszel-Fedorowicz, Indrani Talukdar, Brian N. Griffith, Callee M. Walsh, Lisa M. Salati
An Exonic Splicing Silencer Is Involved In The Regulated Splicing Of Glucose 6-Phosphate Dehydrogenase Mrna, Wioletta Szeszel-Fedorowicz, Indrani Talukdar, Brian N. Griffith, Callee M. Walsh, Lisa M. Salati
Faculty & Staff Scholarship
No abstract provided.
Antisperm Immunity For Contraception, R. K. Naz
Antisperm Immunity For Contraception, R. K. Naz
Faculty & Staff Scholarship
No abstract provided.
Loss Of Caveolin-1 Polarity Impedes Endothelial Cell Polarization And Directional Movement, Andrew Beardsley, Kai Fang, Heather Mertz, Vince Castranova, Sherri Friend, Jun Liu
Loss Of Caveolin-1 Polarity Impedes Endothelial Cell Polarization And Directional Movement, Andrew Beardsley, Kai Fang, Heather Mertz, Vince Castranova, Sherri Friend, Jun Liu
Faculty & Staff Scholarship
No abstract provided.
Nitric Oxide Negatively Regulates Fas Cd95-Induced Apoptosis Through Inhibition Of Ubiquitin-Proteasome-Mediated Degradation Of Flice Inhibitory Protein, Pithi Chanvorachote, Ubonthip Nimmannit, Liying Wang, Christian Stehlik, Bin Lu, Neelam Azad, Yon Rojanasakul
Nitric Oxide Negatively Regulates Fas Cd95-Induced Apoptosis Through Inhibition Of Ubiquitin-Proteasome-Mediated Degradation Of Flice Inhibitory Protein, Pithi Chanvorachote, Ubonthip Nimmannit, Liying Wang, Christian Stehlik, Bin Lu, Neelam Azad, Yon Rojanasakul
Faculty & Staff Scholarship
No abstract provided.
A Streptococcal Collagen-Like Protein Interacts With The Α 2 Β 1 Integrin And Induces Intracellular Signaling, Joseph O. Humtsoe, Jiyeun K. Kim, Yi Xu, Douglas R. Keene, Magnus Höök, Slawomir Lukomski, Kishore K. Wary
A Streptococcal Collagen-Like Protein Interacts With The Α 2 Β 1 Integrin And Induces Intracellular Signaling, Joseph O. Humtsoe, Jiyeun K. Kim, Yi Xu, Douglas R. Keene, Magnus Höök, Slawomir Lukomski, Kishore K. Wary
Faculty & Staff Scholarship
No abstract provided.
Vascular Endothelial Growth Factor Transcriptional Activation Is Mediated By Hypoxia-Inducible Factor 1Α, Hdm2, And P70s6k1 In Response To Phosphatidylinositol 3-Kinase/Akt Signaling, Heath D. Skinner, Jenny Z. Zheng, Jing Fang, Faton Agani, Bing-Hua Jiang
Vascular Endothelial Growth Factor Transcriptional Activation Is Mediated By Hypoxia-Inducible Factor 1Α, Hdm2, And P70s6k1 In Response To Phosphatidylinositol 3-Kinase/Akt Signaling, Heath D. Skinner, Jenny Z. Zheng, Jing Fang, Faton Agani, Bing-Hua Jiang
Faculty & Staff Scholarship
No abstract provided.
The Health Belief Model And Factors Relating To Potential Use Of A Vaccine For Shigellosis In Kaeng Koi District, Saraburi Province, Thailand, Piyarat Butraporn, Alfred Pach, Robert P. Pack, Rungwit Masngarmmeung
The Health Belief Model And Factors Relating To Potential Use Of A Vaccine For Shigellosis In Kaeng Koi District, Saraburi Province, Thailand, Piyarat Butraporn, Alfred Pach, Robert P. Pack, Rungwit Masngarmmeung
Faculty & Staff Scholarship
Shigellosis is an important cause of morbidity and mortality throughout the world. Approximately, 1.1 million deaths occur a year due to this disease, making it the fourth leading cause of mortality worldwide. This paper explores local interest in and potential use of a vaccine for shigellosis in Thailand where Shigella poses an important public-health concern. Data for this study were collected during June- November 2002 from 522 subjects surveyed using a sociobehavioural questionnaire in Kaeng Koi district in central Thailand. The community demand and likely use of a vaccine were examined in relation to the Health Belief Model, which provides …