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Ligand- And Strain-Specific Control Of Microbial Communities, Austin Grant Rottinghaus
Ligand- And Strain-Specific Control Of Microbial Communities, Austin Grant Rottinghaus
McKelvey School of Engineering Theses & Dissertations
Microbes naturally coexist in complex, multi-strain communities that are valuable assets for their host. Commensal and probiotic microbes prevent pathogen colonization, reduce the frequency and severity of various ailments, provide essential nutrients, and offer various additional benefits. Understanding the dynamics of and tailoring microbial communities to provide additional beneficial functions is a primary focus of researchers in medicine and agriculture. To date, consortia have primarily been manipulated by supplementing the communities with microbes that were engineered in vitro or by introducing stimuli that alter the metabolism or composition of the community. This method has proven successful, with numerous microbes engineered …