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Mechanisms Of Induction And Maintenance Of Constitutive Ptgs2 Expression In Colonic Mesenchymal Stem Cells, Monica Drylewicz
Mechanisms Of Induction And Maintenance Of Constitutive Ptgs2 Expression In Colonic Mesenchymal Stem Cells, Monica Drylewicz
All Theses and Dissertations (ETDs)
Colonic injury and inflammation exhibit high morbidity and mortality in western society and are increasingly diagnosed in human patients. In many models of such gastrointestinal insults, prostaglandin endoperoxide synthetase 2: Ptgs2; cyclooxygenase 2) and its downstream synthetic products, most notably prostaglandin E2, support proliferation and modulate the inflammatory immune response, two functions involved in proper injury response. We identified a primary source of this mediator as a population of stromal cells constitutively expressing Ptgs2 that appear to be required in two different model injury systems: administration of dextran sodium sulfate: DSS) and colonic biopsy. The central role of Ptgs2-expressing cells …
Molecular Insights Into The Uropathogenesis Of Enterococcus Faecalis And Escherichia Coli In The Context Of Urinary Catheterization, Pascale Guiton
Molecular Insights Into The Uropathogenesis Of Enterococcus Faecalis And Escherichia Coli In The Context Of Urinary Catheterization, Pascale Guiton
All Theses and Dissertations (ETDs)
Nosocomial urinary tract infections: UTIs) are a very common result of catheterization with 3 to 7% risk of developing catheter-associated UTIs: CAUTIs) each day catheterized. As multi-drug resistance increases in uropathogens, it is imperative to better understand the effects of catheterization on the urinary tract and pathogenesis. Further, microbial colonization and biofilm production on the surface of urinary catheters are a common component of CAUTIs. Thus, this dissertation focuses on understanding the contribution of known biofilm determinants to urovirulence of Enterococcus faecalis: a common nosocomial uropathogen) and uropathogenic Escherichia coli: UPEC): the most common causative agent of UTI), and the …
The Role Of Snail Homolog 1 In Embryonic Stem Cell Differentiation, Jennifer Gill
The Role Of Snail Homolog 1 In Embryonic Stem Cell Differentiation, Jennifer Gill
All Theses and Dissertations (ETDs)
During gastrulation, epiblast cells undergo an epithelial-to-mesenchymal transition: EMT) as they ingress through the primitive streak and form mesoderm. To better understand the molecular pathways of EMT during this developmental transition, we developed a model system utilizing mouse embryonic stem: ES) cells. We show that EMT occurs during ES cell differentiation and is dependent on the Wnt signaling pathway. We further show that the Wnt-dependent transcription factor Snail homolog 1: Snail) is expressed and capable of inducing EMT in differentiating ES cells. In addition to EMT, Snail accelerates differentiation, promotes mesoderm commitment, and restricts markers of primitive ectoderm and epiblast. …