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Knowledge, Perception, And Clinical Management Strategies Of Us Pediatric Dentists On Molar Incisor Hypomineralization, Courtney T. Brashier Jan 2021

Knowledge, Perception, And Clinical Management Strategies Of Us Pediatric Dentists On Molar Incisor Hypomineralization, Courtney T. Brashier

Theses and Dissertations

Purpose: The purpose of this cross-sectional, survey-based study is to determine current US pediatric dentists’ knowledge, perceptions, and clinical management strategies for patients with molar incisor hypomineralization (MIH).

Methods: Following appropriate protocol and authorizations, all active pediatric dentists, general dentists, and post-doctoral student members identified by the 2020 American Academy of Pediatric Dentistry’s membership list were invited to partake in an anonymous email survey. Data regarding participants sociodemographic, education, and clinical backgrounds were collected in addition to information obtained from MIH-focused questions. Descriptive statistics and chi-square tests were used to compare and analyze data. A significance level was set at …


Efficient Vengeance: The Role Of Processing Fluency In Making Decisions About Retaliation, Samuel J. West Jan 2021

Efficient Vengeance: The Role Of Processing Fluency In Making Decisions About Retaliation, Samuel J. West

Theses and Dissertations

Aggressive behavior is a harmful and pervasive psychological and behavioral phenomenon. Inherent to every act of aggression are decisions regarding the modality, severity, and timing of such actions. Prevailing theories of aggression emphasize the role of cognitive processes in aggression, especially retaliatory aggression. Despite this emphasis, few cognitive processes have been examined for their possible involvement in making decisions about retaliatory aggression. Across two studies, I examined the role of processing fluency in making decisions about retaliation. I drew from contemporary models of aggression (e.g., the General Aggression Model) and processing fluency (e.g., the Multi-Source Account) to develop hypotheses in …


The Value Of Postoperative Appointments Following Full Mouth Dental Rehabilitation Under General Anesthesia, Priyanka Patel Jan 2021

The Value Of Postoperative Appointments Following Full Mouth Dental Rehabilitation Under General Anesthesia, Priyanka Patel

Theses and Dissertations

Purpose: Follow-up appointments after full mouth dental rehabilitation under general anesthesia (GA) have been suggested as a method for preventing future caries and need for repeat treatment under GA. The purpose of this study is to determine current practitioner and parental perceived value of the postoperative GA appointment.

Methods: Three separate surveys were administered for this study. The pre-appointment survey asked about the guardian’s desire to have a follow-up appointment. At the follow-up appointment, the post-appointment survey ascertained the level of patient satisfaction with their follow-up appointment and postoperative experience. American Academy of Pediatric Dentistry (AAPD) members were e-mailed a …


Treatment Outcome Of Perforation Repair With Bio-Ceramic Based Materials: A Retrospective Study, Lolwa Alyahya Jan 2021

Treatment Outcome Of Perforation Repair With Bio-Ceramic Based Materials: A Retrospective Study, Lolwa Alyahya

Theses and Dissertations

INTRODUCTION:

The aim of this retrospective cohort study was to assess the treatment outcome of orthograde perforation repair using bio-ceramic based materials.

METHODs:

Data from the VCU graduate endodontic practice were analyzed retrospectively. Treatment had been conducted by VCU endodontic residents under the supervision of qualified endodontists during the period from August 2014-December 2020. All cases in which a bio-ceramic based material had been used as a perforation repair material were included. Bio-ceramic based materials included MTA, EndoSequence Root Repair Material Putty and Paste (ERRM), and iRoot BP Plus Root Repair Material (BP-RRM). Perforation repair was performed using a dental …


Leading In Crooked Rooms: Race, Gender, Culture And Black Women's Leadership Skills And Practices, Portia Newman Jan 2021

Leading In Crooked Rooms: Race, Gender, Culture And Black Women's Leadership Skills And Practices, Portia Newman

Theses and Dissertations

The literature on Black women leaders, where it exists, focuses on the barriers to Black women becoming leaders or being fully empowered when in leadership positions. However, to understand the leadership identity of Black women, and perhaps help to explain the absence of Black women in formal leadership spaces, means to examine the influence of race, gender, and culture on leadership behavior, as well as the setting in which leadership exists. This qualitative grounded theory study explored the leadership skills and practices of 15 senior-level cross sector Black women leaders. The data was collected in two phases: 1) a leadership …


Difficult Paintings, Hao (Damien) Ding Jan 2021

Difficult Paintings, Hao (Damien) Ding

Theses and Dissertations

The sublime as a concept has a fraught and racist history. However, it remains the single most helpful idea in describing the deeply felt state of being when one comes across something ineffably powerful. From an art-making perspective, this thesis, and the accompanying exhibition of installations and paintings, proposes an alternative construction of the concept of the sublime. Using Lacanian psychoanalysis as a conceptual point of departure, a painter can manipulate the relationship of the viewer and paintings to create paradoxical moments of simultaneous intimacy and distance, which interact to create an alternative path towards the sublime. Through descriptions of …


Art Museum Docent Coordinators’ Perceptions: A Difficult Kind Of Balancing Act, Jennifer E. Schero Jan 2021

Art Museum Docent Coordinators’ Perceptions: A Difficult Kind Of Balancing Act, Jennifer E. Schero

Theses and Dissertations

With visitors numbering in the millions, museums provide numerous entry points for attendees to engage with the objects in their care, including offering tours of their collections. Looking specifically at art museums, many institutions utilize volunteers to facilitate these guided looking experiences. Considerable research within the field of museum education focuses on the qualities of effective touring and methods and theories to support these endeavors. However, there is a lack of research focusing on the docent coordinators who oversee these volunteer guides. This study utilizes interpretive phenomenological analysis to explore perceptions of encyclopedic art museum docent coordinators concerning their preparation …


The Role Of Community Belongingness In The Mental Health And Well-Being Of Black Lgbtq Adults, Keith Justin Watts Jan 2021

The Role Of Community Belongingness In The Mental Health And Well-Being Of Black Lgbtq Adults, Keith Justin Watts

Theses and Dissertations

The impact of racial and sexual minority stigma, prejudice, and discrimination on the mental health and well-being of Black and LGBTQ individuals, respectively, has been well documented in the literature. Research on these relationships for Black LGBTQ individuals who are multiply marginalized due to their position at the social intersections of gender identity, sexual orientation, and race/ethnicity is less common. Belongingness to identity-based communities can protect against the negative impact of these minority stressors for Black and LGBTQ individuals and aid coping processes. However, Black LGBTQ individuals often experience stigma and discrimination in their racial, sexual, and gender minority communities …


Heavy Hold: A Physical Score, Alexandra Velozo Jan 2021

Heavy Hold: A Physical Score, Alexandra Velozo

Theses and Dissertations

This document is a collection of essays, stories, and fictional interviews that are in conversation with my performance, teaching, and sculpture practice. My research and work considers chronic illness, disability, the historic cultural connection between swamplands and illness, the medical industrial complex, medical theater, the medical gaze, disabled performers, metatactile space, sensory learning, and access.


The Importance Of Connection: Contributions Of Relationships With Fathers And Connections To School To Delinquent Behavior And Positive Youth Development, Colleen S. Walsh Jan 2021

The Importance Of Connection: Contributions Of Relationships With Fathers And Connections To School To Delinquent Behavior And Positive Youth Development, Colleen S. Walsh

Theses and Dissertations

Risk-taking and boundary pushing are hallmarks of adolescent behavior, making the identification of promotive and protective factors related to both delinquent behavior and positive adolescent functioning essential. Previous studies have provided compelling evidence that suggests aspects of familial relationships may successfully attenuate delinquent behavior and support positive functioning outcomes. Despite these findings, the father-adolescent relationship is understudied in association with these outcomes. The current study examined relations between adolescents’ perception of school connectedness and father-adolescent relationship quality and delinquent behavior and positive adolescent functioning outcomes. This study used data collected when youth were nine and fifteen years old from the …


Comparing The Sensitivity And Specificity Of Cbct And Mri In Detecting Osteoarthritis Of The Tmj: A Systematic Review, Gabriel R. Saavedra Jan 2021

Comparing The Sensitivity And Specificity Of Cbct And Mri In Detecting Osteoarthritis Of The Tmj: A Systematic Review, Gabriel R. Saavedra

Theses and Dissertations

The aim of this systematic review was to compare the sensitivity and specificity of cone-beam computed tomography (CBCT) and magnetic resonance imaging (MRI) in detecting osteoarthritis (OA) of the temporomandibular joint (TMJ). This was done by using computed tomography (CT) and the research diagnostic criteria for temporomandibular disorders (RDC/TMD) as reference methods and using CBCT and MRI as index methods. A specific search strategy was developed and applied to these electronic databases: PubMed, Embase, DOSS, and Cochrane. The search results returned 802 articles, which were then narrowed down using the inclusion/exclusion criteria, to four final articles that were included in …


Intermittent Theta Burst Stimulation: Application To Spinal Cord Injury Rehabilitation And Computational Modeling, Neil Mittal Jan 2021

Intermittent Theta Burst Stimulation: Application To Spinal Cord Injury Rehabilitation And Computational Modeling, Neil Mittal

Theses and Dissertations

Loss of motor function from spinal cord injuries (SCI) results in loss of independence. Rehabilitation efforts are targeted to enhance the ability to perform activities of daily living (ADLs), but outcomes from physical therapy alone are often insufficient. Neuromodulation techniques that induce neuroplasticity may push the limits on recovery. Neuromodulation by intermittent theta burst transcranial magnetic stimulation (iTBS) induces neuroplasticity by increasing corticomotor excitability, though this has most frequently been studied with motor targets and on individuals not in need of rehabilitation. Increased corticomotor excitability is associated with motor learning. The response to iTBS, however, is highly variable and unpredictable, …


Are The Tickets For Everyone? Heterogeneity Of Economic Rewards For Associate’S Degree Completion, Kathleen E. Lee Jan 2021

Are The Tickets For Everyone? Heterogeneity Of Economic Rewards For Associate’S Degree Completion, Kathleen E. Lee

Theses and Dissertations

Associate’s degree completion has been billed as the quickest way to upskill the workforce and a ticket to the middle class (Carnevale et al., 2018; Gittell et al., 2017). Yet, over 35 million Americans have left college without a degree (Wheatle et al., 2017). Black and Hispanic students are more likely than White and Asian students to leave college before completing a degree (Shapiro et al., 2017). This study examined if economic benefits differ between those whose highest level of educational attainment is “some college, no degree (SCND)” and an associate’s degree, specifically by analyzing heterogeneity and interaction effects between …


Feeling The Squeeze: The Association Between Multigeneration Caregiving And Informal Caregivers’ Health, Christine L. Patterson Jan 2021

Feeling The Squeeze: The Association Between Multigeneration Caregiving And Informal Caregivers’ Health, Christine L. Patterson

Theses and Dissertations

While U.S. public policy and research has focused on the health needs of the aging population, less attention has been given to the consequences informal caregivers face caring for this generation. With the segment of the population aged 65 years or older growing rapidly, it is important to understand the factors that place informal caregivers at risk for poor health outcomes and health behaviors. Since multigeneration caregivers balance more personal, work, and caregiving demands than single-generation informal caregivers of older adults, they may be at higher risk for poor health outcomes. The aim of this study was to examine the …


Preventing Obesity: A Social Ecological Exploration Of Centers For Disease Control Prevention Strategies And Guidance Toward Healthy Eating, Physical Activity, And Communities, Ryan Kelly Jan 2021

Preventing Obesity: A Social Ecological Exploration Of Centers For Disease Control Prevention Strategies And Guidance Toward Healthy Eating, Physical Activity, And Communities, Ryan Kelly

Theses and Dissertations

Abstract

Obesity has reached nearly 40% of the adult public in the United States, costing the citizen taxpayer over $200 billion annually in healthcare costs. Those suffering from obesity deal with multiple physical and mental repercussions. Through a content analysis of four Centers for Disease Control (CDC) documents and guided by the conceptual framework of the social ecological model, this research explores the federal approach to preventing obesity. The analysis finds that CDC solutions to obesity involve connecting people to each other and healthier choices, an orientation toward local public administration, and an emphasis on environmental and infrastructure improvements. The …


The Relationships Between Adolescents’ Future Aspirations And Postsecondary Enrollment: Finite Mixture Models, Chu Yi Lu Qiu Jan 2021

The Relationships Between Adolescents’ Future Aspirations And Postsecondary Enrollment: Finite Mixture Models, Chu Yi Lu Qiu

Theses and Dissertations

This study took person-centered statistical approaches to explore the multidimensional construct of adolescents' future aspirations and its associations with three covariates (i.e., gender, race, and SES) and a binary, distal outcome measure, postsecondary enrollment. Fourteen survey items representing the multidimensionality of adolescents' future aspirations were extracted from two-waves of Educational Longitudinal Study:2002 student data. The multidimensionality or the latent construct of the adolescents' future aspirations were explored using two finite mixture models called latent class analysis (LCA) and latent transition analysis (LTA). Based on the students' response patterns on the fourteen indicators, three latent classes representing three levels of aspiration …


Modeling Substance Use And Mental Disorder Comorbidity Using Latent Variable And Network Approaches, Courtney T. Blondino Jan 2021

Modeling Substance Use And Mental Disorder Comorbidity Using Latent Variable And Network Approaches, Courtney T. Blondino

Theses and Dissertations

Introduction. Substance use disorder (SUD) is a common condition that affects millions of Americans. Addressing SUD has been complicated by comorbid mental disorders and co-occurring substance use. Consequently, detailing and addressing SUD and comorbid SUD represent an important goal to improve the health of Americans.

Objective. The research goal of this dissertation was to characterize the comorbidity between substance use, including tobacco use, and mental disorder symptoms measured as negative affect and externalizing symptoms in a population-based sample using latent variable and network approaches.

Methods. Waves 1 – 3 from the Population Assessment of Tobacco and Health Study were used. …


Grief, Loss, And Climate Change: Validation Of A Solastalgia Scale, Claire Luce Jan 2021

Grief, Loss, And Climate Change: Validation Of A Solastalgia Scale, Claire Luce

Theses and Dissertations

Climate change has been identified as a defining issue of this century (United Nations, n.d.). Climate change impacts human wellbeing including mental health. While much research has focused on the way that the effects of climate change cause increases in common mental disorders, mental health is not just the absence of these disorders (World Health Organization, 2014). Non-pathologized mental health responses to climate change, such as the grief and loss that results from climate change impacts, are a growing consideration for researchers. Solastalgia, or the distress experienced in the absence of the solace once provided by the environment in the …


The Impacts Of Peer Observation Roles And Teaching Characteristics On Teacher Self-Efficacy: A Secondary Data Analysis Study Using The Talis Survey, Elisa Tedona Jan 2021

The Impacts Of Peer Observation Roles And Teaching Characteristics On Teacher Self-Efficacy: A Secondary Data Analysis Study Using The Talis Survey, Elisa Tedona

Theses and Dissertations

It is important for teachers to have a high sense of self-efficacy, as it is one of the prime motivational forces influencing student learning, teacher quality, and in turn, overall success (Curry, 2015; Hattie, 2009; Klassen & Chiu, 2010). Teachers with high self-efficacy work harder, are more involved in learning, and have higher assurance (Bandura, 1994). For these reasons, it is imperative to study the influencers of teacher self-efficacy. Peer observations and observational feedback, a highly used practice in all schools, is one of those influencers. This cycle of observations and feedback provided to teachers is influential to teacher self-efficacy …


Urate Genetic Assessment In Asian And Pacific Islander Subgroups Of Pregnant Women: Implications For Personalized Medicine And Means To Reduce Health Disparities, Ali Alghubayshi Jan 2021

Urate Genetic Assessment In Asian And Pacific Islander Subgroups Of Pregnant Women: Implications For Personalized Medicine And Means To Reduce Health Disparities, Ali Alghubayshi

Theses and Dissertations

Gout is one of the most common rheumatic conditions and appears to have a higher prevalence in certain populations. Risk factors for gout and its precursor, hyperuricemia, are also significant risk factors for preeclampsia, major pregnancy-related morbidity. A retrospective cross-sectional study was conducted on 1059 pregnant women from different populations whom 100% reported their ethnicities from the Asian, Native Hawaiian, and Pacific Islander populations. Numerous uric acid (UA) genes and clinical conditions were addressed, and all study details were reviewed and exempted by the University of Hawaii human Studies Program (Protocol Number: 2018-00225). In this project, we hypothesized that UA …


Statistical Approaches For Estimation And Comparison Of Brain Functional Connectivity, Jifang Zhao Jan 2021

Statistical Approaches For Estimation And Comparison Of Brain Functional Connectivity, Jifang Zhao

Theses and Dissertations

Drug addiction can lead to many health-related problems and social concerns. Functional connectivity obtained from functional magnetic resonance imaging (fMRI) data promotes a variety of fundamental understandings in such association. Due to its complex correlation structure and large dimensionality, the modeling and analysis of the functional connectivity from neuroimage are challenging. By proposing a spatio-temporal model for multi-subject neuroimage data, we incorporate voxel-level spatio-temporal dependencies of whole-brain measurements to improve the accuracy of statistical inference. To tackle large-scale spatio-temporal neuroimage data, we develop a computationally efficient algorithm to estimate the parameters. Our method is used to identify functional connectivity and …


Sleep-Related Problems, Sleep-Related Distress, And Sleep-Related Functional Status Among Adult Inpatients Receiving Palliative Care, Lisa C. Sievers Jan 2021

Sleep-Related Problems, Sleep-Related Distress, And Sleep-Related Functional Status Among Adult Inpatients Receiving Palliative Care, Lisa C. Sievers

Theses and Dissertations

Palliative care patients may be at a higher risk for sleep-related problems and their negative effects compared to the general population, yet limited sleep research has been done with this population. The purpose of this dissertation was to determine prevalence rates for excessive sleepiness, insomnia, restless legs syndrome (RLS), and high risk for sleep apnea (HRSA); examine relationships between the aforementioned sleep-related problems, sleep-related distress (SD), and sleep-related functional status (SFS); and to determine which sleep-related problem measures along with age and gender predicted SD and SFS among a sample of adult palliative care inpatients. Secondary aims were to understand …


Breaking The Cycle: A Longitudinal Study Of Factors That Disrupt Peer Selection And Influence Processes Among Urban Youth, Kelly E. Oconnor Jan 2021

Breaking The Cycle: A Longitudinal Study Of Factors That Disrupt Peer Selection And Influence Processes Among Urban Youth, Kelly E. Oconnor

Theses and Dissertations

Having friends who engage in problem behavior (i.e., aggression, substance use, delinquency) has consistently been linked to adolescents’ own engagement in problem behavior. There are, however, several key gaps in the literature on peer influence. Few studies have considered the influence of friends’ prosocial behavior and there has been limited research to identify promotive factors that influence urban youths’ affiliation with peers who engage in problem and prosocial behavior across early adolescence, a time of heightened susceptibility to peer influence. The purpose of this study was to identify modifiable promotive factors that reduce adolescents’ problem behavior by decreasing exposure to …


Theorizing #Girlboss Culture: Mediated Neoliberal Feminisms From Influencers To Multi-Level Marketing Schemes, Frankie Mastrangelo Jan 2021

Theorizing #Girlboss Culture: Mediated Neoliberal Feminisms From Influencers To Multi-Level Marketing Schemes, Frankie Mastrangelo

Theses and Dissertations

I define girlboss feminism as emergent, mediated formations of neoliberal feminism that equate feminist empowerment with financial success, market competition, individualized work-life balance, and curated digital and physical presences driven by self-monetization. I look toward how the mediation of girlboss feminism utilizes branded and affective engagements with representational politics, discourses of authenticity and rebellion, as well as meritocratic aspiration to promote cultural interest in conceptualizing feminism in ways that are divorced from collective, intersectional struggle. I question the stakes involved in reducing feminist interrogations and commitments to discourses of representation, visibility, and meritocracy. I argue that while girlboss feminism may …


Black Feminist Thought, Interrupted: Dissecting The Voice Of Black Feminists In The Blogosphere And Their Engagement With Platform Affordances, Dawn G. Johnson Jan 2021

Black Feminist Thought, Interrupted: Dissecting The Voice Of Black Feminists In The Blogosphere And Their Engagement With Platform Affordances, Dawn G. Johnson

Theses and Dissertations

ABSTRACT

BLACK FEMINIST THOUGHT, INTERRUPTED

DISSECTING THE VOICE OF BLACK FEMINISTS IN THE BLOGOSPHERE AND THEIR ENGAGEMENT WITH PLATFORM AFFORDANCES

By Dawn G. Johnson, Ph.D

A dissertation submitted to the faculty at Virginia Commonwealth University in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Media, Art, and Text Department in the College of Humanities and Sciences

Virginia Commonwealth University, 2021

Dissertation Chair: Dr. Archana Pathak, Associate Professor, Dept. of Gender, Sexuality & Women's Studies, Virginia Commonwealth University

Black women that have long searched for spaces to be creative and have voice due to their …


First-Year Retention At Virginia Commonwealth University: Understanding Student Departure And The Potential Impact Of Academic Advising, Ben Plache Jan 2021

First-Year Retention At Virginia Commonwealth University: Understanding Student Departure And The Potential Impact Of Academic Advising, Ben Plache

Theses and Dissertations

This dissertation examines first-year enrollment at Virginia Commonwealth University to determine what factors are associated with an increased likelihood of a student not being retained, and for which of these factors there is evidence that academic advising is an effective intervention. A survey of common retention models identified six factors associated with retention likelihood: student background prior to enrollment (“pre-enrollment factors”), financial support, institutional support, institutional performance, institutional engagement, and student intention. Prior research has shown that academic advising is an effective intervention for two of these factors: institutional performance and institutional support.

The significance of these factors was tested …


Value Of Pediatric Sleep Questionnaire In Referrals For Obstructive Sleep Apnea At Vcu Pediatric Dental Clinic, Elizabeth H. Hering Jan 2021

Value Of Pediatric Sleep Questionnaire In Referrals For Obstructive Sleep Apnea At Vcu Pediatric Dental Clinic, Elizabeth H. Hering

Theses and Dissertations

Purpose: The purpose of this study is to determine the number of VCU pediatric dental patients screened for obstructive sleep apnea (OSA) relative to the number of referrals made for a pediatric sleep study.

Methods: This was a retrospective chart review of children between the ages of 1-18 years seen at the VCU Pediatric Dental Clinic between 2016-2020. Patients with a completed sleep apnea screening questionnaire in the health history form or sleep apnea form/referral were identified. The data was used to determine how many referrals were made for a pediatric sleep study in patients screening positive for sleep apnea. …


Socio-Ecological Predictors Of Social Connection Among Older Adults, Georganna Amateau Jan 2021

Socio-Ecological Predictors Of Social Connection Among Older Adults, Georganna Amateau

Theses and Dissertations

Decades of research has established an unequivocal link between states of social connection and health status. Lack of social connection, whether construed as social isolation or loneliness, negatively influences health and is highly associated with cardiovascular disease, high blood pressure, fall risk, and premature death. Despite extensive research on social isolation and loneliness, evidence relative to the broader construct of social connection suffers. Few studies inform practice standards for community-based organizations. This study aimed to develop a multidimensional, continuous composite variable of social connection and use the composite variable to examine predictors with a socio-ecological lens.

A secondary data analysis …


Understanding Predictors Of Telemedicine Adoption Before, During, And After The Covid-19 Pandemic, Bradford S. Pierce Jan 2021

Understanding Predictors Of Telemedicine Adoption Before, During, And After The Covid-19 Pandemic, Bradford S. Pierce

Theses and Dissertations

This study examined change in physicians’ use of telemedicine before, during, and expectations after the COVID-19 pandemic. It also examined the ability of personal and environmental variables to predict telemedicine adoption, and applied the theory of reasoned action and technology acceptance model to physicians’ adoption of telemedicine during the pandemic. A total of 230 licensed physicians currently practicing in the United States were recruited. Telemedicine accounted for 3.72% of physicians’ clinical work prior to the pandemic, 46.03% during the pandemic, and predicted 25.44% after the pandemic ends. Physicians within hospitals reported less telemedicine use during the pandemic (M = …


Ck2 Phosphorylation Of Human Papillomavirus 16 E2 On Serine 23 Promotes Interaction With Topbp1 And Is Critical For E2 Plasmid Retention Function, Apurva Tadimari Prabhakar Jan 2021

Ck2 Phosphorylation Of Human Papillomavirus 16 E2 On Serine 23 Promotes Interaction With Topbp1 And Is Critical For E2 Plasmid Retention Function, Apurva Tadimari Prabhakar

Theses and Dissertations

Human papillomaviruses (HPVs) are the causative agents in most cervical cancers and have been implicated in a rising number of oropharyngeal cancers. HPV positive oropharyngeal cancers have increased significantly over the last two decades with no specific anti-viral therapeutic options for the treatment of HPV diseases. During its lifecycle, HPV16 encoded E2 protein interacts with host cellular factors to regulate viral transcription, replication and genome segregation/retention. Our understanding of the cellular partner proteins that E2 uses to mediate its functions remains incomplete.

Previously, an interaction between E2 and the host protein TopBP1 was identified. In earlier studies, it was also …