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Bacterial Artificial Chromosome Clones Of Viruses Comprising The Towne Cytomegalovirus Vaccine, Xiaohong Cui, Stuart P. Adler, Andrew J. Davison, Larry Smith, El-Sayed E. Habib, Michael A. Mcvoy
Bacterial Artificial Chromosome Clones Of Viruses Comprising The Towne Cytomegalovirus Vaccine, Xiaohong Cui, Stuart P. Adler, Andrew J. Davison, Larry Smith, El-Sayed E. Habib, Michael A. Mcvoy
Pediatrics Publications
Bacterial artificial chromosome (BAC) clones have proven invaluable for genetic manipulation of herpesvirus genomes. BAC cloning can also be useful for capturing representative genomes that comprise a viral stock or mixture. The Towne live attenuated cytomegalovirus vaccine was developed in the 1970s by serial passage in cultured fibroblasts. Although its safety, immunogenicity, and efficacy have been evaluated in nearly a thousand human subjects, the vaccine itself has been little studied. Instead, genetic composition and in vitro growth properties have been inferred from studies of laboratory stocks that may not always accurately represent the viruses that comprise the vaccine. Here we …
Changes In Subcellular Localization Reveal Interactions Between Human Cytomegalovirus Terminase Subunits, Jian Ben Wang, Yali Zhu, Michael A. Mcvoy, Deborah S. Parris
Changes In Subcellular Localization Reveal Interactions Between Human Cytomegalovirus Terminase Subunits, Jian Ben Wang, Yali Zhu, Michael A. Mcvoy, Deborah S. Parris
Pediatrics Publications
No abstract provided.
An Observational Study On Cough In Children: Epidemiology, Impact On Quality Of Sleep And Treatment Outcome, Francesco De Blasio, Peter V. Dicpinigaitus, Bruce K. Rubin, Gianluca De Danieli, Luigi Lanata, Alessando Zanasi
An Observational Study On Cough In Children: Epidemiology, Impact On Quality Of Sleep And Treatment Outcome, Francesco De Blasio, Peter V. Dicpinigaitus, Bruce K. Rubin, Gianluca De Danieli, Luigi Lanata, Alessando Zanasi
Pediatrics Publications
Background Cough is one of the most frequent symptoms in children and is the most common symptom for which children visit a health care provider.
Methods This is an observational study on acute cough associated with upper respiratory tract infection (URTI) in children. The study evaluates the epidemiology and impact of cough on quality of sleep and children's activities, and the outcome of cough with antitussive treatments in pediatric routine clinical practice. Study assessments were performed through a pediatric cough questionnaire (PCQ), developed by the Italian Society of Cough Study. A total of 433 children visited by family care pediatricians …