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The Anti-Thyroid Effects Of Halogenated Phenols And Pyridinols, Leland Steven Beck
The Anti-Thyroid Effects Of Halogenated Phenols And Pyridinols, Leland Steven Beck
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
This research was initiated to determine the mechanism(s) of action that could explain increased weight gain and decreased milk production in dairy cattle fed corn silage containing residues of certain organophosphate pesticides. It was proposed that the mode of action involved and alteration of thyroid physiology by the metabolites of the pesticides, namely halogenated phenols. Studies were carried out to determine the effect of tri-halogenated phenols and pyridinols upon T4-binding to bovine serum albumin (BSA) and to liver mitochondria isolated from male rats. Using the rat as a model, feeding trials were performed to determine the effect of …