Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Acid, But Not Capsaicin, Is An Effective Stimulus For Atp Release In The Porcine Bladder Mucosa, Prajni Sandananda, Kylie J. Mansfield, Elizabeth Burcher
Acid, But Not Capsaicin, Is An Effective Stimulus For Atp Release In The Porcine Bladder Mucosa, Prajni Sandananda, Kylie J. Mansfield, Elizabeth Burcher
Graduate School of Medicine - Papers (Archive)
Hypothesis / aims of study: Urothelial ATP release is thought to play an important role in bladder afferent signaling via activation of purinergic receptors on suburothelial afferent nerves. Stretch of the bladder mucosa is a well documented stimulus for ATP release in several species, including the pig [1]. In addition, in mouse bladder, capsaicin is also an effective stimulus for ATP release, acting via stimulation of vanilloid (TRPV1) receptors [2]. While acid is an agonist at the TRPV1 receptor, specialized acid sensing ion channels (ASICs) are also present in several organ systems [3]. Our aim was to characterize the ATP …