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Trends In Bmi, Diet And Lifestyle Between 1976 And 2005 In North Sydney, Lillian M. Kent, Anthony Worsley
Trends In Bmi, Diet And Lifestyle Between 1976 And 2005 In North Sydney, Lillian M. Kent, Anthony Worsley
Faculty of Health and Behavioural Sciences - Papers (Archive)
Although the prevalence of overweight and obesity in Australia has increased during the past 30 years, little is known about the dietary and behavioural antecedents of body mass index (BMI). We examined changes in mean BMI, diet, and other lifestyle behaviours between 1976 and 2005 and described the cross-sectional associations between these factors and BMI. A series of biennial biomedical surveys by Sydney Adventist Hospital from 1976 to 2005 allowed examination of BMI trends, while the selection of three surveys enabled detailed examination of likely dietary and lifestyle associations. Subjects included in this study were: 384 men and 338 women …
Interactions Between Deformation And Fluids In The Frontal Thrust Region Of The Nantroseize Transect Offshore The Kii Peninsula, Japan: Results From Iodp Expedition 316 Sites C0006 And C0007, E Screaton, G Kimura, D Curewitz, G Moore, F Chester, O Fabbri, Christopher L. Fergusson, F Girault, D Goldsby, R Harris, F Inagaki, T Jiang, Y Kitamura, M Knuth, C-F Li, L Claesson Liljedahl, L Louis, K Milliken, U Nicholson, N Riedinger, A Sakaguchi, E Solomon, M Strasser, X Su, A Tsutsumi, A Yamaguchi, K Ujiee, X. Zhao
Interactions Between Deformation And Fluids In The Frontal Thrust Region Of The Nantroseize Transect Offshore The Kii Peninsula, Japan: Results From Iodp Expedition 316 Sites C0006 And C0007, E Screaton, G Kimura, D Curewitz, G Moore, F Chester, O Fabbri, Christopher L. Fergusson, F Girault, D Goldsby, R Harris, F Inagaki, T Jiang, Y Kitamura, M Knuth, C-F Li, L Claesson Liljedahl, L Louis, K Milliken, U Nicholson, N Riedinger, A Sakaguchi, E Solomon, M Strasser, X Su, A Tsutsumi, A Yamaguchi, K Ujiee, X. Zhao
Faculty of Science - Papers (Archive)
Integrated Ocean Drilling Program (IODP) Expedition 316 Sites C0006 and C0007 examined the deformation front of the Nankai accretionary prism offshore the Kii Peninsula, Japan. In the drilling area, the frontal thrust shows unusual behavior as compared to other regions of the Nankai Trough. Drilling results, integrated with observations from seismic reflection profiles, suggest that the frontal thrust has been active since similar to 0.78-0.436 Ma and accommodated similar to 13 to 34% of the estimated plate convergence during that time. The remainder has likely been distributed among out-of-sequence thrusts further landward and/or accommodated through diffuse shortening. Unlike results of …
Error Correlation Between Co2 And Co As Constraint For Co2 Flux Inversions Using Satellite Data, H Wang, D J. Jacob, M Kopacz, D B. A Jones, P Suntharalingam, J A. Fisher, R Nassar, S Pawson, J E. Nielsen
Error Correlation Between Co2 And Co As Constraint For Co2 Flux Inversions Using Satellite Data, H Wang, D J. Jacob, M Kopacz, D B. A Jones, P Suntharalingam, J A. Fisher, R Nassar, S Pawson, J E. Nielsen
Faculty of Science - Papers (Archive)
Inverse modeling of CO2 satellite observations to better quantify carbon surface fluxes requires a chemical transport model (CTM) to relate the fluxes to the observed column concentrations. CTM transport error is a major source of uncertainty. We show that its effect can be reduced by using CO satellite observations as additional constraint in a joint CO2-CO inversion. CO is measured from space with high precision, is strongly correlated with CO2, and is more sensitive than CO2 to CTM transport errors on synoptic and smaller scales. Exploiting this constraint requires statistics for the CTM transport error correlation between CO2 and CO, …
Ranking Habitat Patches By Contribution To Network Connectivity: Tradeoffs Between Processing Time And Spatial Realisation, B Cook, Marjetta L. Puotinen, Rittick Borah
Ranking Habitat Patches By Contribution To Network Connectivity: Tradeoffs Between Processing Time And Spatial Realisation, B Cook, Marjetta L. Puotinen, Rittick Borah
Faculty of Science - Papers (Archive)
No abstract provided.
A Fluorescence Quenching Assay To Discriminate Between Specific And Non-Specific Inhibitors Of Dengue Virus Protease, C Bodenreider, D Beer, T Keller, S Sonntag, D Wen, Li Yap, Y H Yau, S G Shocat, D Huang, T Zhou, A Caflisch, X C Su, Kiyoshi Ozawa, G Otting, S G. Vasudevan, J Lescar, S P. Lim
A Fluorescence Quenching Assay To Discriminate Between Specific And Non-Specific Inhibitors Of Dengue Virus Protease, C Bodenreider, D Beer, T Keller, S Sonntag, D Wen, Li Yap, Y H Yau, S G Shocat, D Huang, T Zhou, A Caflisch, X C Su, Kiyoshi Ozawa, G Otting, S G. Vasudevan, J Lescar, S P. Lim
Faculty of Science - Papers (Archive)
In drug discovery, the occurrence of false positives is a major hurdle in the search for lead compounds that can be developed into drugs. A small-molecular-weight compound that inhibits dengue virus protease at low micromolar levels was identified in a screening campaign. Binding to the enzyme was confirmed by isothermal titration calorimetry (ITC) and nuclear magnetic resonance (NMR). However, a structure-activity relationship study that ensued did not yield more potent leads. To further characterize the parental compound and its analogues, we developed a high-speed, low-cost, quantitative fluorescence quenching assay. We observed that specific analogues quenched dengue protease fluorescence and showed …
Nmr Analysis Of The Dynamic Exchange Of The Ns2b Cofactor Between Open And Closed Conformations Of The West Nile Virus Ns2b-Ns3 Protease, X Su, Kiyoshi Ozawa, R Qi, S G. Vasudevan, S P. Lim, G Otting
Nmr Analysis Of The Dynamic Exchange Of The Ns2b Cofactor Between Open And Closed Conformations Of The West Nile Virus Ns2b-Ns3 Protease, X Su, Kiyoshi Ozawa, R Qi, S G. Vasudevan, S P. Lim, G Otting
Faculty of Science - Papers (Archive)
Background: The two-component NS2B-NS3 proteases of West Nile and dengue viruses are essential for viral replication and established targets for drug development. In all crystal structures of the proteases to date, the NS2B cofactor is located far from the substrate binding site (open conformation) in the absence of inhibitor and lining the substrate binding site (closed conformation) in the presence of an inhibitor. Methods: In this work, nuclear magnetic resonance (NMR) spectroscopy of isotope and spin-labeled samples of the West Nile virus protease was used to investigate the occurrence of equilibria between open and closed conformations in solution. Findings: In …
Nmr Study Of Complexes Between Low Molecular Mass Inhibitors And The West Nile Virus Ns2b-Ns3 Protease, X Su, Kiyoshi Ozawa, Hiromasa Yagi, S P. Lim, D Wen, D Ekonomiuk, D Huang, T Keller, S Sonntag, A Caflisch, S G. Vasudevan, G Otting
Nmr Study Of Complexes Between Low Molecular Mass Inhibitors And The West Nile Virus Ns2b-Ns3 Protease, X Su, Kiyoshi Ozawa, Hiromasa Yagi, S P. Lim, D Wen, D Ekonomiuk, D Huang, T Keller, S Sonntag, A Caflisch, S G. Vasudevan, G Otting
Faculty of Science - Papers (Archive)
The two-component NS2B-NS3 protease of West Nile virus is essential for its replication and presents an attractive target for drug development. Here, we describe protocols for the high-yield expression of stable isotope-labelled samples in vivo and in vitro. We also describe the use of NMR spectroscopy to determine the binding mode of new low molecular mass inhibitors of the West Nile virus NS2B-NS3 protease which were discovered using high-throughput in vitro screening. Binding to the substrate-binding sites S1 and S3 is confirmed by intermolecular NOEs and comparison with the binding mode of a previously identified low molecular mass inhibitor. Our …