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University of Wisconsin Milwaukee

Theses and Dissertations

2022

FMRI

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Prior Experiences Of Racial Discrimination Impact Acute Resting-State Connectivity Of The Bnst As A Predictor Of Ptsd In Black Adults, Kevin Petranu Dec 2022

Prior Experiences Of Racial Discrimination Impact Acute Resting-State Connectivity Of The Bnst As A Predictor Of Ptsd In Black Adults, Kevin Petranu

Theses and Dissertations

Altered resting-state activity of the bed nucleus of the stria terminalis (BNST) – which mediates anxious arousal and threat monitoring – is implicated in the etiology of posttraumatic stress disorder (PTSD). Experiences of racial discrimination can also increase one’s risk for developing PTSD by eliciting chronic states of hypervigilance, which impair essential resting-state processes related to fear extinction. Considering the frequency in which Black Americans experience racial discrimination, the current study investigated acute BNST resting-state functional connectivity as a predictor of future PTSD symptoms, as well as the impact of racial discrimination on the BNST as a predictor of PTSD. …


Prior Experiences Of Racial Discrimination Impact Acute Resting-State Connectivity Of The Bnst As A Predictor Of Ptsd In Black Adults, Kevin Petranu Dec 2022

Prior Experiences Of Racial Discrimination Impact Acute Resting-State Connectivity Of The Bnst As A Predictor Of Ptsd In Black Adults, Kevin Petranu

Theses and Dissertations

Altered resting-state activity of the bed nucleus of the stria terminalis (BNST) – which mediates anxious arousal and threat monitoring – is implicated in the etiology of posttraumatic stress disorder (PTSD). Experiences of racial discrimination can also increase one’s risk for developing PTSD by eliciting chronic states of hypervigilance, which impair essential resting-state processes related to fear extinction. Considering the frequency in which Black Americans experience racial discrimination, the current study investigated acute BNST resting-state functional connectivity as a predictor of future PTSD symptoms, as well as the impact of racial discrimination on the BNST as a predictor of PTSD. …


The Cumulative Impact Of Childhood Adversity On Bold Responses To Inhibitory Control During Early Adolescence In The Abcd Study Cohort, Elizabeth Ashley Stinson May 2022

The Cumulative Impact Of Childhood Adversity On Bold Responses To Inhibitory Control During Early Adolescence In The Abcd Study Cohort, Elizabeth Ashley Stinson

Theses and Dissertations

Adolescence is characterized by dynamic neurodevelopment, which poses opportunities for risk and resilience. Adverse childhood experiences (ACEs) pose additional risk to the developing brain, where ACEs have been associated with alterations in functional magnetic resonance imaging (fMRI) BOLD signaling in brain regions underlying inhibitory control. Potential resiliency factors, like positive family environment, may attenuate the risk associated with ACEs. Using baseline to 2-year data from the Adolescent Brain Cognitive Development (ABCD) Study, the current study examined how ACEs relate to fMRI BOLD signaling during successful inhibition on the Stop Signal Task (SST) in regions underlying inhibitory control during early adolescence …