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University of Wisconsin Milwaukee

Theses and Dissertations

2021

PTSD

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Effect Of Neighborhood Socioeconomic Disadvantage On Brain Functional Connectivity And Structural Properties In Trauma-Exposed Adults, Elisabeth Kathleen Webb Dec 2021

Effect Of Neighborhood Socioeconomic Disadvantage On Brain Functional Connectivity And Structural Properties In Trauma-Exposed Adults, Elisabeth Kathleen Webb

Theses and Dissertations

Though there has been substantial progress towards understanding brain-behavior relationships and characterizing the neurobiology of psychiatric disorders, research has not translated as expected into novel prevention and treatment of mental health conditions. One limitation may be the emphasis on individual-level variables (e.g., income) and omission of relevant area-level factors (e.g., neighborhood socioeconomic disadvantage). Recently, attention has been directed towards identifying the biological mechanisms by which neighborhoods impact mental health. The chronic stress associated with living in a disadvantaged neighborhood promotes a cascade of maladaptive events, which in turn impact brain structure and functioning. The processes affected by chronic neighborhood stressors …


Neural Correlates Underlying The Interactions Between Anxiety And Cannabis Use In Predicting Motor Response Inhibition, Richard Ward May 2021

Neural Correlates Underlying The Interactions Between Anxiety And Cannabis Use In Predicting Motor Response Inhibition, Richard Ward

Theses and Dissertations

The ability to effectively withhold an inappropriate response is a critical feature of cognitive control. Prior research indicates alterations in neural processes required for motor response inhibition in anxious individuals, including those with posttraumatic stress disorder (PTSD), and those who engage in regular cannabis use. However, thus far most research has examined how anxiety-related symptoms and cannabis use influence response inhibition in isolation of one another. The current study examined the interactions between anxious symptomology and recent cannabis use in a sample that recently experienced a traumatic event using functional magnetic resonance imaging (fMRI) during the completion of a Stop-Signal …