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Part I, Unified Pharmacophore Protein Models Of The Benzodiazepine Receptor Subtypes ; Part Ii, Subtype, Terrill S. Clayton
Part I, Unified Pharmacophore Protein Models Of The Benzodiazepine Receptor Subtypes ; Part Ii, Subtype, Terrill S. Clayton
Theses and Dissertations
Part I. New models of unified pharmacophore/receptors have been constructed guided by the synthesis of subtype selective compounds in light of recent developments both in ligand synthesis and structural studies of the binding site itself. The evaluation of experimental data in combination with comparative models of the α1β2γ2, α2β2γ2, α3β2γ2 and α5β2γ2 GABA(A) receptors has led to an orientation of the pharmacophore model within the benzodiazepine binding site (Bz BS). These results not only are important for the rational design of new selective ligands, but also for the identification and evaluation of possible roles which specific residues may have within …
Spirituality And Transformational Learning: How Urban Residents Abandoned A Life Of Violence, Sylvia N. Wilson
Spirituality And Transformational Learning: How Urban Residents Abandoned A Life Of Violence, Sylvia N. Wilson
Theses and Dissertations
Community violence has been a perpetual issue among disenfranchised, African American, urban youth around the world. Many authors argue that high rates of violence among these youth are due to macro-structural characteristics such as inequality, segregation, racial discrimination, and poverty. These macro-structural issues place stressors (social disorganization, joblessness, alienation, mistrust of police, etc.) upon inner-city neighborhoods. Previous research also infers that African American men lack the ability to non-violently cope with these stressors and strains. Thus, this qualitative narrative study investigated the role of spirituality in the transformational process of nine urban, African American men, who had abandoned a life …