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The Activity Of Qh Ii 66 And It’S Analogs In Medulloblastoma, Melanoma And Non-Small Cell Lung Cancer Cell Lines., Taukir Ahmed
The Activity Of Qh Ii 66 And It’S Analogs In Medulloblastoma, Melanoma And Non-Small Cell Lung Cancer Cell Lines., Taukir Ahmed
Theses and Dissertations
GABAARs (gamma-aminobutyric acid type A receptors) are transmembrane pentameric ligand-gated chloride ion channels that respond to GABA, the central nervous system's principal inhibitory neurotransmitter (CNS). The benzodiazepines (BZDs) bind between the GABAAR α+γ2-subunits at their extracellular interface. The binding of ligands to distinct subunits of GABAA receptors, notably the α1-6β2/3γ2 ion channels, can have a wide range of effects on brain activities. The sedative, ataxic, amnesic, anticonvulsant, and addictive actions of GABAARs' α1-subtype selective ion channels should be avoided, except for the anticonvulsant and anxiolytic effects, while creating ligands for this BZ allosteric modulatory site. Many studies have linked the …
Characterization Of Dna Interstrand Cross-Linking Agents By Liquid Chromatograhy-Mass Spectrometry, Anahit Marina Campbell
Characterization Of Dna Interstrand Cross-Linking Agents By Liquid Chromatograhy-Mass Spectrometry, Anahit Marina Campbell
Theses and Dissertations
This study is to characterize novel reactive oxygen species (ROS)-activated nitrogen mustard analogues and UV-activated alkylating agents by Liquid Chromatography-Mass Spectrometry (LC-MS). First, we optimized the instrument conditions to successfully ionize a few novel binapthalene analogues and methoxybenzene analogues by MS. The highest signal intensity for compounds 3-10 was observed when atmospheric pressure chemical ionization (APCI) with an optimized corona needle position of 5mm or 10 mm was used, which led to successful analysis of compounds 3-10 by MS. Second, we determined pharmacokinetic properties of a drug compound (FAN-NM-CH3), including animal study, assay development, optimization of MS/MS instrumental parameter and …
Histone Deacetylase Inhibition Induces Apoptosis And Cell Cycle Dysregulation In Human And Murine Cancer Cell Lines, Joseph Skurski
Histone Deacetylase Inhibition Induces Apoptosis And Cell Cycle Dysregulation In Human And Murine Cancer Cell Lines, Joseph Skurski
Theses and Dissertations
Carcinogenesis is a complex multistep process that requires tumor cells to grow rapidly while overcoming growth inhibitory signals and sustained challenges from the host immune response. Mutations within promoter or enhancer regions, along with epigenetic changes, can induce aberrant expression of genes that regulate differentiation, cell cycle, and apoptosis, all of which enhance potential for cellular transformation. In recent years, our understanding of the biological processes that influence the activation and repression of transcription have evolved to highlight the role of chromatin architecture, and how chromatin remodeling may be utilized for the potential therapeutic benefit of genetic disease. Histone deacetylase …
The Waiting House, Erika Marie Mueller
The Waiting House, Erika Marie Mueller
Theses and Dissertations
The poems in this collection, The Waiting House, use techniques associated with an evolving elegiac tradition in their portrayal of anticipatory grief born of terminal illness and impending loss. Like the melancholic mourning of modern elegies described by Jahan Ramazani, my poems often resist consolation even as they borrow from elegiac conventions like poetic substitution and repetition. Additionally, they utilize strategies and patterns of literary anger outlined by Alicia Suskin Ostriker as common in postwar American women’s poetry, to express anger that is also anticipatory grief. Finally, this collection uses illness metaphors to question the well being of a larger …