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Some Biochemical Aspects Of Nitric Oxide In Biological Systems., Christopher Michael. Howard
Some Biochemical Aspects Of Nitric Oxide In Biological Systems., Christopher Michael. Howard
Electronic Theses and Dissertations
The role of nitric oxide (NO) in biological systems is becoming increasingly important. Initially, the effect of NO on the transport of L-arginine into human platelets was studied. NO is known to have an effect on this system, and platelets have been shown to possess an isoform of the enzyme nitric oxide synthase. Two NO donors (S-nitrosoglutathione and S-nitroso-N-acetyl penicillamine), a source of NO$\sp{+}$ and a solution of authentic NO were used to measure the effect of NO on the L-arginine transport system. The toxicity of nitric oxide can be due to its direct effects, or more likely through higher …
Characterization Of Calmodulin Binding Properties Of A Phage Display Peptide Series And The Peptide Analogues Of Kirgem Sm-Mlck And Neuromodulin Using Fluorescence Spectroscopy., Wendy Joan. Stevenson
Characterization Of Calmodulin Binding Properties Of A Phage Display Peptide Series And The Peptide Analogues Of Kirgem Sm-Mlck And Neuromodulin Using Fluorescence Spectroscopy., Wendy Joan. Stevenson
Electronic Theses and Dissertations
An M13 Phage Display library experiment by Dr. B. Kay (University of North Carolina) yielded a lone Ca$\sp{2+}$ dependent calmodulin-binding peptide (12.1). Point mutations to the C-terminus and the central Gly 13 Gly 14 residues of this peptide were made to study their effect on the peptide binding to Cam. This series of peptides was denoted as the 'Evolved' series of peptides (52). Two sources of this peptide series were used during experiments, one provided by Dr. B. Kay, University of North Carolina (K series) and a second from Dr. G. Laloie, University of Waterloo (UW series). Fluorescence spectral titrations …
The Preparation, Characterization, And Application Of Thin Film Devices., Bob. Berno
The Preparation, Characterization, And Application Of Thin Film Devices., Bob. Berno
Electronic Theses and Dissertations
This thesis deals with the preparation of two thin film devices, in particular a nitrogen dioxide (NO$\sb2$) gas sensor and a rechargeable lithium battery. A number of different thin film preparation techniques were used for a variety of applications and the resultant films were characterized by spectroscopic and electrochemical methods. The NO$\sb2$ gas sensor was based on Langmuir-Blodgett (LB) monolayer films of the sandwich molecule europium bisphthalocyanine (EuPc$\sb2$). The intense UV-visible absorption spectrum of a monolayer of the EuPc$\sb2$ dye molecules was recorded before and after exposure to NO$\sb2$ gas. It was noted that with time the film spectrum returned …
Peroxynitrite Modification Of Calmodulin: Structural And Functional Consequences., Peterson. Pathrose
Peroxynitrite Modification Of Calmodulin: Structural And Functional Consequences., Peterson. Pathrose
Electronic Theses and Dissertations
Nitric oxide (NO), a free radical species is an important retrograde messenger in cell regulation, but is cytotoxic in higher concentrations. Superoxide (O$\sb2\sp{{\cdot}-}$) and NO react yielding peroxynitrite anion (OONO$\sp-)$ which is a potent and toxic oxidant that can attack a wide range of biological targets, for eg. in regulation of blood flow, neurotransmission, sepsis etc. In proteins, peroxynitrite mediated damage occurs via nitration of the aromatic side chains. In the present study, we examined the susceptibility of the two Tyr residues of calmodulin (CaM) to OONO$\sp-$ mediated nitration in vitro as indicated by the amino acid analysis. CaM and …
Heterometallic And Homometallic Complexes Containing Bifunctional Ligands And Their Application In High-Temperature Oxide Superconductor Materials., Steven R. Breeze
Heterometallic And Homometallic Complexes Containing Bifunctional Ligands And Their Application In High-Temperature Oxide Superconductor Materials., Steven R. Breeze
Electronic Theses and Dissertations
We have been interested in the development of soluble precursors for the production of YBa$\sb2$Cu$\sb3$O$\sb{7-\delta}$ and Bi$\sb2$(Ca,Sr)$\sb{\rm n+1}$Cu$\sb{\rm n}$O$\sb{\rm (2n + 4) + \delta}$, superconductor materials. Several heterometallic and homometallic complexes containing the constituent metals of these superconductors and bifunctional ligands such as aminoalcohols, acetates and thioethers have been isolated and structurally characterized. The thermal decomposition properties and magnetic properties of some of these compounds have been investigated. The first ligand system investigated involved 1,3-bis(dimethylamino)-2-propanol (bdmapH). By varying the ratio of bdmapH, Cu(OCH$\sb3)\sb2$, and M(O$\sb2$CCF$\sb3)\sb2$ (M = Ca, Sr) several heterometallic complexes have been obtained, including Sr$\sb2$Cu$\sb2$(bdmap)$\sb4$(O$\sb2$CCF$\sb3)\sb4$, CaCu(bdmap)$\sb2$(O$\sb2$CCF$\sb3)\sb3$(H$\sb2$O), Sr$\sb2$Cu$\sb4$(bdmap)$\sb6$-(O$\sb2$CCF$\sb3)\sb4(\mu\sb 3$-OH)$\sb2$(THF)$\sb2$ …