Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
Characterizing Phenotypic Effects Of Spy1 Mediated Lateral Branching, Iulian Eric Derecichei
Characterizing Phenotypic Effects Of Spy1 Mediated Lateral Branching, Iulian Eric Derecichei
Electronic Theses and Dissertations
Mammary development is a continuous and cyclic process that is under tight regulatory control from hormones and cell cycle regulators to mediate transition from the various proliferative, differential and apoptotic steps. Puberty is a time-point of high proliferation during development that has higher susceptibility to breast cancer. Spy1 is a cyclin-like protein known to regulate mammary development and increase proliferation with previous work also showing Spy1 increases tumor susceptibility and pubertal lateral side branching. ¬In this work we demonstrate that elevated levels of Spy1 in puberty significantly increase the number of lateral branches and total epithelial content in mice. Similarly, …
Anticancer Activity Of Natural Health Products (Dandelion Root, Lemongrass, And Hibiscus Extracts); A Study Of Efficacy, Interaction, And Mechanism Of Action, Christopher Vu Nguyen
Anticancer Activity Of Natural Health Products (Dandelion Root, Lemongrass, And Hibiscus Extracts); A Study Of Efficacy, Interaction, And Mechanism Of Action, Christopher Vu Nguyen
Electronic Theses and Dissertations
Cancer continues to be the leading cause of death in Canada. Many conventional chemotherapies have indicated side effects due to a lack of treatment specificity and are thus not suitable for long-term usage. Natural health products (NHPs) are well-tolerated and safe for consumption, and some have pharmaceutical uses particularly for their anti-cancer effects. We have previously investigated the anti-cancer efficacy of dandelion (Taraxacum officinale) root, lemongrass (Cymbopogon citratus), and hibiscus (Hibiscus syriacus) extracts. However, their efficacy on prostate, colorectal, and breast cancer as well as their interactions with standard chemotherapeutics have not been studied to determine if they will be …