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Statistical Genetic Approaches To Investigate Genotype-By-Environment Interaction: Review And Novel Extension Of Models, Vincent P. Diego, Eron G. Manusov, Marcio Almeida, Sandra Laston, David Ortiz, John Blangero, Sarah Williams-Blangero Apr 2024

Statistical Genetic Approaches To Investigate Genotype-By-Environment Interaction: Review And Novel Extension Of Models, Vincent P. Diego, Eron G. Manusov, Marcio Almeida, Sandra Laston, David Ortiz, John Blangero, Sarah Williams-Blangero

School of Medicine Publications and Presentations

Statistical genetic models of genotype-by-environment (G×E) interaction can be divided into two general classes, one on G×E interaction in response to dichotomous environments (e.g., sex, disease-affection status, or presence/absence of an exposure) and the other in response to continuous environments (e.g., physical activity, nutritional measurements, or continuous socioeconomic measures). Here we develop a novel model to jointly account for dichotomous and continuous environments. We develop the model in terms of a joint genotype-by-sex (for the dichotomous environment) and genotype-by-social determinants of health (SDoH; for the continuous environment). Using this model, we show how a depression variable, as measured by the …


Investigating The Potential Double-Edged Score Of Immigration-Related Stress, Discrimination, And Mental Health Access, Arthur R. Andrews, Kevin Escobar, Sandra Mariely Estrada Gonzalez, Sara Reyes, Laura M. Acosta Mar 2024

Investigating The Potential Double-Edged Score Of Immigration-Related Stress, Discrimination, And Mental Health Access, Arthur R. Andrews, Kevin Escobar, Sandra Mariely Estrada Gonzalez, Sara Reyes, Laura M. Acosta

Psychological Science Faculty Publications and Presentations

Prior work has suggested that discrimination and immigration-related stress may impede mental health care seeking and utilization among Latinx populations. These effects may be more nuanced as both discrimination and immigration-related stress may increase symptomology, particularly post-traumatic stress disorder (PTSD) and depression. Both symptoms may, in turn, prompt attempts to seek care. The current study examined the direct effects of discrimination and immigration-related stress on care access, as well as potentially indirect effects with PTSD and depression symptoms as mediators. Interviews and online surveys were completed with 234 Latinx residents of the Midwest, assessing everyday discrimination, discrimination in healthcare, PTSD …


Invarianza De La Escala De Evaluación De Las Relaciones Intrafamiliares En Padres Con Y Sin Migración De Retorno Y Salud Mental [Invariance Of The Intrafamily Relations Evaluation Scale In Parents With And Without Return Migration And Mental Health], María Elena Rivera Heredia, Patricia Andrade Palos, Jaime Fuentes Balderrama, Luis H. Zayas Feb 2024

Invarianza De La Escala De Evaluación De Las Relaciones Intrafamiliares En Padres Con Y Sin Migración De Retorno Y Salud Mental [Invariance Of The Intrafamily Relations Evaluation Scale In Parents With And Without Return Migration And Mental Health], María Elena Rivera Heredia, Patricia Andrade Palos, Jaime Fuentes Balderrama, Luis H. Zayas

School of Social Work Faculty Publications and Presentations

Se analizaron las propiedades psicométricas de la Escala de Evaluación de las Relaciones Intrafamiliares (ERI) en padres de familia que retornaron a México y que tienen hijos e hijas menores de edad nacidos en E.E.U.U., así como en padres mexicanos sin experiencia migratoria. Participaron189 padres (92 retornados y 97 sin migración). Se llevaron a cabo Análisis Factoriales Exploratorios y Confirmatorios para derivar una versión culturalmente invariante. Una vez obtenidas las evidencias de invarianza configural, métrica, escalar, estricta y estructural, se encontró mediante un modelo de ecuaciones estructurales que la unión y apoyo familiar se asocian con la sintomatología depresiva y …


“It’S Not That We Care Less”: Insights Into Health Care Utilization For Comorbid Diabetes And Depression Among Latinos, Sharon Borja, Miriam G. Valdovinos, Kenia M. Rivera, Natalia Giraldo-Santiago, Robin Gearing, Luis R. Torres-Hostos Jan 2024

“It’S Not That We Care Less”: Insights Into Health Care Utilization For Comorbid Diabetes And Depression Among Latinos, Sharon Borja, Miriam G. Valdovinos, Kenia M. Rivera, Natalia Giraldo-Santiago, Robin Gearing, Luis R. Torres-Hostos

School of Social Work Faculty Publications and Presentations

Despite robust knowledge regarding the socio-economic and cultural factors affecting Latino* access to healthcare, limited research has explored service utilization in the context of comorbid conditions like diabetes and depression. This qualitative study, embedded in a larger mixed-methods project, aimed to investigate perceptions held by Latinos and their social support systems (i.e., family members) regarding comorbid diabetes and depression and to identify barriers and facilitators to their help-seeking behaviors and treatment engagement. Bilingual and bicultural researchers conducted eight focus groups with 94 participants in a large U.S. metropolitan area and were primarily conducted in Spanish. The participants either had a …