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A Comparative Analysis Of Positive And Negative Stimuli For Takotsubo Cardiomyopathy: A Pooled Analysis Of Two Studies And A Systematic Review, Arankesh Mahadevan, Vamsikalayan Borra, Lakshmi Prasanna Vaishnavi Kattamuri, Vikash Jaiswal, Ikechukwu R. Ogbu

School of Medicine Publications and Presentations

Takotsubo cardiomyopathy (TTC) is characterized by transient myocardial dysfunction triggered by both negative and positive emotional experiences, known respectively as broken heart syndrome (BHS) and happy heart syndrome (HHS). Despite the scarcity of comparative analyses between HHS and BHS in the literature, our pooled analysis, incorporating two retrospective registry analyses of 1395 TTC patients (57 HHS and 1338 BHS), reveals that while BHS is more prevalent, both conditions exhibit similar clinical presentations and outcomes. Statistical analyses, utilizing binary random effects models, indicate that diabetes mellitus is less common in HHS patients and serves as a predictor for BHS. Furthermore, there …