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Genetic Influence On The Working Memory Circuitry: Behavior, Structure, Function And Extensions To Illness, Katherine H. Karlsgodt, Peter Bachman, Anderson M. Winkler, Carrie E. Bearden, David C. Glahn
Genetic Influence On The Working Memory Circuitry: Behavior, Structure, Function And Extensions To Illness, Katherine H. Karlsgodt, Peter Bachman, Anderson M. Winkler, Carrie E. Bearden, David C. Glahn
School of Medicine Publications and Presentations
Working memory is a highly heritable complex cognitive trait that is critical for a number of higher-level functions. However, the neural substrates of this behavioral phenotype are intricate and it is unknown through what precise biological mechanism variation in working memory is transmitted. In this review we explore different functional and structural components of the working memory circuitry, and the degree to which each of them is contributed to by genetic factors. Specifically, we consider dopaminergic function, glutamatergic function, white matter integrity and gray matter structure all of which provide potential mechanisms for the inheritance of working memory deficits. In …
Blood Pressure And Cerebral White Matter Share Common Genetic Factors In Mexican Americans, Peter Kochunov, David C. Glahn, Jack Lancaster, Anderson M. Winkler, Rene L. Olvera, Joanne E. Curran, Thomas D. Dyer, Laura Almasy, Ravi Duggirala, Peter T. Fox, John Blangero
Blood Pressure And Cerebral White Matter Share Common Genetic Factors In Mexican Americans, Peter Kochunov, David C. Glahn, Jack Lancaster, Anderson M. Winkler, Rene L. Olvera, Joanne E. Curran, Thomas D. Dyer, Laura Almasy, Ravi Duggirala, Peter T. Fox, John Blangero
School of Medicine Publications and Presentations
Elevated arterial pulse pressure and blood pressure (BP) can lead to atrophy of cerebral white matter (WM), potentially attributable to shared genetic factors. We calculated the magnitude of shared genetic variance between BP and fractional anisotropy of water diffusion, a sensitive measurement of WM integrity in a well-characterized population of Mexican Americans. The patterns of whole-brain and regional genetic overlap between BP and fractional anisotropy were interpreted in the context the pulse-wave encephalopathy theory. We also tested whether regional pattern in genetic pleiotropy is modulated by the phylogeny of WM development. BP and high-resolution (1.7 × 1.7 × 3 mm; …