Digital Commons Network^™

Bismuth Nitrate Pentahydrate-Induced Novel Nitration Of Eugenol, Luis Canales, Debasish Bandyopadhyay, Bimal K. Banik

Chemistry Faculty Publications and Presentations

Background: Eugenol, the main constituent of clove oil possesses a number of medicinal activities. To enhance the medicinal property, structural modification is required. On the other hand, bismuth nitrate pentahydrate has been established as an excellent eco-friendly nitrating agent for several classes of organic compounds.

Results: Bismuth nitrate pentahydrate-induced nitration of eugenol has been investigated very thoroughly. Twenty five different conditions have been studied. The microwave-induced solvent-free reaction has been identified as the best condition.

Conclusions: Spectral analyses confirm that 5-nitroeugenol is the sole product in all the cases. No oxidized or isomerized product could be detected.

Antimicrobial Activity Of Eugenol Derivatives, George Eyambe, Luis Canales, Bimal K. Banik

Chemistry Faculty Publications and Presentations

The antibacterial properties of the clove plant are due to the presence of eugenol, an aromatic phenolic compound. Eugenol was isolated from clove by stem distillation. The alkene group in eugenol was epoxidized resulting in the synthesis of epoxide-eugenol. The heterocyclic ring in epoxide was cleaved to a bromoalcohol derivative. The compounds synthesized epoxideeugenol, bromo alcohol and euginol were tested for antimicrobial activity against Staphylococcus aureus (ATCC 25923). Epoxide-eugenol was found to be the most effective antimicrobial agent among the three compounds tested.