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Effectiveness Of Different Molecular Weights And Concentrations Of Chitosan On Enteric Viral Surrogates, Robert Hamilton Davis
Effectiveness Of Different Molecular Weights And Concentrations Of Chitosan On Enteric Viral Surrogates, Robert Hamilton Davis
Masters Theses
Chitosan is known to be antibacterial and antifungal, but information on its effectiveness against foodborne viruses is limited. Enteric viruses are a major concern in food safety, especially human noroviruses which are the leading cause of nonbacterial gastroenteritis. The overall goal of this research was to determine the antiviral effectiveness of chitosan. The specific objectives were to determine the effects of molecular weight (MW) and concentration of chitosan against the cultivable enteric viral surrogates, feline calicivirus (FCV-F9), murine norovirus (MNV-1), and bacteriophages (MS2 and phiX174). Purified chitosans (53, 222, 307, 421, ~1,150kDa) were dissolved in water, 1% acetic acid, or …
Depolymerization Of Chitosan By High-Pressure Homogenization And The Effect On Antimicrobial Properties, Deidra Shannon Lyons
Depolymerization Of Chitosan By High-Pressure Homogenization And The Effect On Antimicrobial Properties, Deidra Shannon Lyons
Masters Theses
The focus of this study was to look at relationship between polydispersity caused by high pressure homogenization and molecular weight dependent antimicrobial activity of chitosan. It has been shown that chitosan has antimicrobial activity against bacteria, fungi, and viruses. Chitosan is obtained by partial de-N-acetylation of chitin which, consists of a ß 1-4 copolymer of glucosamine and N-acetylglucosamine residues. In this experiment we compared chitosan of sixteen different molecular weights after being processed through a high pressure homogenizer. Processed chitosan (420 kDa average molecular weight, 30% of acetylation) was dissolved in a 1% (v/v) acetic acid in water to a …