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Chemical Disinfectants For Inactivation Of Human Norovirus Surrogates, Cong Cao
Chemical Disinfectants For Inactivation Of Human Norovirus Surrogates, Cong Cao
Masters Theses
Human noroviruses (HNoVs) are considered the leading cause of acute non-bacterial gastroenteritis worldwide. Effective chemical disinfectants to inactivate HNoVs are needed. Since HNoVs cannot be cultivated in the lab, cultivable surrogates, feline calicivirus (FCV-F9) and murine norovirus (MNV-1), are used to determine inactivation using infectivity plaque assays. This study aimed to: 1) determine the ability of benzalkonium chloride (BAC) and potassium peroxymonosulfate (KPMS) to inactivate FCV-F9 and MNV-1 in vitro using suspension and carrier tests under clean and simulated dirty (5% fetal bovine serum) conditions over 1 h at room temperature; 2) determine inactivation of FCV-F9 and MNV-1 in suspension …