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Articles 1 - 5 of 5
Full-Text Articles in Entire DC Network
Evaluating Contribution Of The Cellular And Humoral Immune Responses To The Control Of Shedding Of Mycobacterium Avium Spp. Paratuberculosis In Cattle, Vitaly V. Ganusov, Don Klinkenberg, Douwe Bakker, Ad P. Koets
Evaluating Contribution Of The Cellular And Humoral Immune Responses To The Control Of Shedding Of Mycobacterium Avium Spp. Paratuberculosis In Cattle, Vitaly V. Ganusov, Don Klinkenberg, Douwe Bakker, Ad P. Koets
Microbiology Publications and Other Works
Mycobacterium avium spp. paratuberculosis (MAP) causes a persistent infection and chronic inflammation of the gut in ruminants leading to bacterial shedding in feces in many infected animals. Although there are often strong MAP-specific immune responses in infected animals, immunological correlates of protection against progression to disease remain poorly defined. Analysis of cross-sectional data has suggested that the cellular immune response observed early in infection is effective at containing bacterial growth and shedding, in contrast to humoral immune responses. In this study, 20 MAP-infected calves were followed for nearly 5 years during which MAP shedding, antigen-specific cellular (LPT) and humoral (ELISA) …
Novel Heparan Sulfate-Binding Peptides For Blocking Herpesvirus Entry, Pranay Dogra, Emily B. Martin, Angela Williams, Raphael L. Richardson, James S. Foster, Nicole Hackenback, Stephen J. Kennel, Tim E. Sparer, Jonathan S. Wall
Novel Heparan Sulfate-Binding Peptides For Blocking Herpesvirus Entry, Pranay Dogra, Emily B. Martin, Angela Williams, Raphael L. Richardson, James S. Foster, Nicole Hackenback, Stephen J. Kennel, Tim E. Sparer, Jonathan S. Wall
Microbiology Publications and Other Works
Human cytomegalovirus (HCMV) infection can lead to congenital hearing loss and mental retardation. Upon immune suppression, reactivation of latent HCMV or primary infection increases morbidity in cancer, transplantation, and late stage AIDS patients. Current treatments include nucleoside analogues, which have significant toxicities limiting their usefulness. In this study we screened a panel of synthetic heparin-binding peptides for their ability to prevent CMV infection in vitro. A peptide designated, p5+14 exhibited ~ 90% reduction in murine CMV (MCMV) infection. Because negatively charged, cell-surface heparan sulfate proteoglycans (HSPGs), serve as the attachment receptor during the adsorption phase of the CMV infection …
Deep Groundwater And Potential Subsurface Habitats Beneath An Antarctic Dry Valley, Jill A. Mikucki, E. Auken, S. Tulaczyk, R. A. Virginia, C. Schamper, K. I. Sørensen, P. T. Doran, H. Dugan, N. Foley
Deep Groundwater And Potential Subsurface Habitats Beneath An Antarctic Dry Valley, Jill A. Mikucki, E. Auken, S. Tulaczyk, R. A. Virginia, C. Schamper, K. I. Sørensen, P. T. Doran, H. Dugan, N. Foley
Microbiology Publications and Other Works
The occurrence of groundwater in Antarctica, particularly in the ice-free regions and along the coastal margins is poorly understood. Here we use an airborne transient electromagnetic (AEM) sensor to produce extensive imagery of resistivity beneath Taylor Valley. Regional-scale zones of low subsurface resistivity were detected that are inconsistent with the high resistivity of glacier ice or dry permafrost in this region. We interpret these results as an indication that liquid, with sufficiently high solute content, exists at temperatures well below freezing and considered within the range suitable for microbial life. These inferred brines are widespread within permafrost and extend below …
Lessening Malaria Parasite Burden With Yogurt, Alivia M. Shasteen, Sarah W. Lebeis, Nathan Schmidt
Lessening Malaria Parasite Burden With Yogurt, Alivia M. Shasteen, Sarah W. Lebeis, Nathan Schmidt
Microbiology Publications and Other Works
The prevalence of malaria across the globe, particularly in countries with minimal health care availability, makes it a top priority for medical researchers. Dr. Nathan Schmidt’s lab discovered that mice from vendors from different geographical locations infected with malaria pathogens yielded significantly different parasite burdens. Researchers discovered that the reason behind the differences in parasite burden was a result of the different compositions of the gut microbiomes of the mice from the different vendors. The research in which I engaged involved manipulating the contents of the gut microbiome through yogurt in the hopes of lessening the parasite burden. Our results …
Mathematical Modeling Provides Kinetic Details Of The Human Immune Response To Vaccination, Dustin Le, Joseph D. Miller, Vitaly V. Ganusov
Mathematical Modeling Provides Kinetic Details Of The Human Immune Response To Vaccination, Dustin Le, Joseph D. Miller, Vitaly V. Ganusov
Microbiology Publications and Other Works
With major advances in experimental techniques to track antigen-specific immune responses many basic questions on the kinetics of virus-specific immunity in humans remain unanswered. To gain insights into kinetics of T and B cell responses in human volunteers we combined mathematical models and experimental data from recent studies employing vaccines against yellow fever and smallpox. Yellow fever virus-specific CD8 T cell population expanded slowly with the average doubling time of 2 days peaking 2.5 weeks post immunization. Interestingly, we found that the peak of the yellow fever-specific CD8 T cell response was determined by the rate of T cell proliferation …