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Neutrophil Subtype Differentiation In Campylobacter Jejuni Infection And Its Impact On T Cells And Colonic Epithelial Cells, Carolina Dolislager
Neutrophil Subtype Differentiation In Campylobacter Jejuni Infection And Its Impact On T Cells And Colonic Epithelial Cells, Carolina Dolislager
Masters Theses
The discovery of neutrophil subtypes has expanded what is known about neutrophil functions, yet there is still much to learn about the role of these subtypes during bacterial infection. We investigated whether Campylobacter jejuniinduced differentiation of human neutrophils into the hypersegmented, CD16hi/CD62Llo[CD16hi/CD62Llo] subtype. In addition, we investigated whether C. jejuni-dependent differentiation of this neutrophil subtype induced cancer promoting activities ofhuman T cells and colonocytes, whichwere observed in other studies of hypersegmented, CD16hi/CD62Llo[CD16hi/CD62Llo] neutrophils. We found that C. jejunicauses a significant shift in human neutrophil populations to the hypersegmented, CD16 …
Campylobacter Infection Of Young Children In A Latin American Middle-Income Country And Its Impact On The Gastrointestinal Environment, Jessica Tweedie
Campylobacter Infection Of Young Children In A Latin American Middle-Income Country And Its Impact On The Gastrointestinal Environment, Jessica Tweedie
Masters Theses
Campylobacter infections are the leading bacterial cause of diarrhea worldwide with potentially profound impacts on pediatric patients in the developing world. It is still unclear how Campylobacter impacts human hosts, though it is becoming increasingly evident that Campylobacters infection’s impact is a multifactorial process that depends on the host immune response, the gastrointestinal microbiota, various bacterial derived metabolites, and possibly the nutritional status of the host. Since these factors likely differ between human-host and bacteria in the developed and developing worlds, it is important that studies comprehensively define these attributes in well characterized clinical cohorts in both settings. In this …
The Roles Of Calprotectin And Calgranulin C In Campylobacter Jejuni Infection, Janette Marie Shank
The Roles Of Calprotectin And Calgranulin C In Campylobacter Jejuni Infection, Janette Marie Shank
Masters Theses
Campylobacter jejuni is a leading cause of bacterial-derived gastroenteritis worldwide. In the developed world, campylobacteriosis is most commonly acquired following the consumption of cross contaminated foods or undercooked poultry meat, since the bacterium asymptomatically colonizes chickens. In the developing world, infection most commonly occurs through drinking contaminated water. Following ingestion, Campylobacter adheres to the intestinal epithelium and mucus layer, causing toxin-mediated inflammation and inhibition of fluid reabsorption. Currently, the bacterial mechanisms behind colonization and disease are relatively unknown. Thus, it is important to identify factors that influence the development of these sequelae during and after initial C. jejuni infection.Ferrets ( …
Application Of Botanicals In Poultry Production To Improve Microbiological Quality, Francisco Javier Gonzalez-Gil
Application Of Botanicals In Poultry Production To Improve Microbiological Quality, Francisco Javier Gonzalez-Gil
Masters Theses
Foodborne illness and outbreaks associated with poultry products are commonly caused by Campylobacter jejuni or Salmonella enterica. These pathogens colonize the bird intestines during rearing, and if processing, handling or cooking is not done properly, contamination and human illness can occur. Probiotics, prebiotics and botanicals are being evaluated as novel feed additives to reduce pathogen colonization and serve as growth promoter additives in poultry production. Some botanicals are of industrial interest because they are natural antimicrobials or possess beneficial effects on human health. In this research, the application of a botanical (yerba mate) and a probiotic were evaluated as …
Development Of Novel Vaccines For Campylobacter Control In Poultry, Lindsay Ann Jones
Development Of Novel Vaccines For Campylobacter Control In Poultry, Lindsay Ann Jones
Masters Theses
Campylobacter is the leading bacterial cause of human enteritis in developed countries. Human campylobacteriosis is commonly associated with consumption of undercooked, contaminated chicken, a natural host of Campylobacter. Thus, control of Campylobacter colonization in poultry at the farm level would reduce the risk of human exposure to this pathogen. Vaccination is an attractive intervention measure to mitigate Campylobacter in poultry. Our recent studies have demonstrated that the outer membrane proteins CmeC (an essential component of CmeABC multidrug efflux pump) and CfrA (ferric enterobactin receptor) are feasible candidates for immune intervention against Campylobacter. By targeting these two promising vaccine …
Impact Of Rearing Conditions On The Microbiological Quality Of Retail Poultry Meat, Bridgshe Hardy
Impact Of Rearing Conditions On The Microbiological Quality Of Retail Poultry Meat, Bridgshe Hardy
Masters Theses
Poultry and poultry products are a leading source of foodborne pathogens and illnesses. The rearing conditions of poultry can be an influential factor on the presence of foodborne pathogens including Campylobacter and Salmonella because some types of rearing practices have increased risks in terms of biosecurity. However, there is a gap in knowledge of food safety in raw chicken products and no studies have reported the microbiological quality of turkeys produced under different rearing environments. Thus, the aim of this study was to compare conventionally and organically-reared whole chicken and turkey carcasses purchased from three retail outlets in Knoxville, TN. …