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Intrinsically Disordered Proteins And Their “Mysterious” (Meta)Physics, Vladimir N. Uversky
Intrinsically Disordered Proteins And Their “Mysterious” (Meta)Physics, Vladimir N. Uversky
Molecular Medicine Faculty Publications
Recognition of the natural abundance and functional importance of intrinsically disordered proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions (IDPRs) and ordered regions, is changing protein science. IDPs and IDPRs, i.e., functional proteins and protein regions without unique structures, can often be found in all organisms, and typically play vital roles in various biological processes. Disorder-based functionality complements the functions of ordered proteins and domains. However, by virtue of their existence, IDPs/IDPRs, which are characterized by remarkable conformational flexibility and structural plasticity, break multiple rules established over the years to explain structure, folding, and functionality of …