Digital Commons Network^™

Diaryl Oxazoles As Cleavable Linkers For Drug Discovery Platforms, Elizabeth Taggart

Honors Theses

Within the field of medicine and pharmacology, discovering small molecule or biologic based molecules with therapeutic potential is a difficult task. Current methods involve individually screening hundreds of compounds on a potential target biomolecule, and recent technologies have explored peptide encoded libraries (PELs) as a means of making this screening process more high-throughput. These libraries produce a large number of small molecule drug candidates each conjugated to a unique peptide fragment, functioning as a barcode. Analysis of PELs requires the capture of hit small molecules and the subsequent release of their peptide tags; however, current approaches are limited in their …

Investigation Of The Vira Linker Domain To Characterize Its Phenol Interactions, Jessica Garofalo

Honors Theses

The soil bacterium Agrobacterium tumefaciens causes tumors in plants through interkingdom gene transfer. This transfer is initiated upon a wounding event that results in the release of plant signaling factors such as phenols and sugars that are recognized by protein machinery in the periplasm and inner membrane of A. tumefaciens. The histidine kinase protein VirA, in combination with the periplasmic protein ChvE, recognizes these signals and initiates induction of virulence genes via a signaling pathway, culminating with the insertion of tumor-inducing T-DNA into the wounded plant cells. While the interaction between the Periplasmic domain of VirA and sugar-bound ChvE …

Gender Based Violence And All It's Erasure, Ana Sofie Martinez

Honors Theses

Part one of three

of a radical act

against

gender-based violence

Out-Of-Time & Out-Of-Place: Queer Horizons Of Popular Culture, Josephine Holland

Honors Theses

This thesis uses Our Flag Means Death to illustrate the ability of Fictional Relativity Theory to unpack a text according to constructs of space-time and the translations from the creation process and and interpretation process, but it is also serves an example of the ways that texts can operate within the structure to encourage and engage with queer potential. OFMD pushes the boundaries and expectations in every step of FRT, from messing with constructs and expectations of time and space, to encouraging queer play and new kinds of engagement with fan communities in the second half of FRT’s cultural production …

Exploring The Structure Of Partial Difference Sets With Denniston Parameters, Nicolas Ferree

Honors Theses

In this work, we investigate the structure of particular partial difference sets (PDS) of size 70 with Denniston parameters in an elementary abelian group and in a nonelementary abelian group. We will make extensive use of character theory in our investigation and ultimately seek to understand the nature of difference sets with these parameters. To begin, we will cover some basic definitions and examples of difference sets and partial difference sets. We will then move on to some basic theorems about partial difference sets before introducing a group ring formalism and using it to explore several important constructions of partial …

Bryophytes Of Goochland County, Virginia, Mikayla Quinn

Honors Theses

Bryophytes are non-vascular land plants that include mosses, liverworts, and hornworts. Although easier to overlook because of their smaller size, bryophytes are a fundamental part of the ecosystem. As such, maintaining record of their biodiversity is important. Yet, records of bryophyte species in Goochland County, VA were low compared to more thoroughly documented counties such as Prince Edward County. This study expands the documentation of bryophyte flora and presents a checklist of bryophyte species found Virginia’s Goochland County from 2020-2023. Fieldwork conducted at public and privately-owned properties throughout the county between January 2020 and March 2023 yielded 702 specimens that …

Perceiving The Poster: How Suspicion Of Motives May Impact Perceptions Of Potential Allies Engaging In Online Activism, Kathrina Z. Durante

Honors Theses

Social media posts signaling support for various social and racial justice movements have emerged as an important aspect of social media use. However, little research has investigated how these posts and the social media users behind them are perceived by members of disadvantaged groups﹘those the messages are presumably intended to “help.” Though the post’s content and poster’s identity are likely important, the primary aim of this study is to investigate an individual difference variable in the perceiver, specifically disadvantaged group members’ Suspicion of Motives Index (SOMI) scores, which measure a general tendency to perceive White individuals’ attempts at non-prejudice to …

The Big Five And Dark Triad: The Role Of Personality In The Development Of Passion, Hannah Behar

Honors Theses

The present work explored the connection between personality and the Dualistic Model of Passion (DMP) and weather psychological safety moderated this relationship. The first study comprised 109 Introduction to Psychology students at the University of Richmond, and the second study measured 128 MTurk participants. The web-based survey administered to both samples consisted of measures assessing Harmonious Passion (HP), Obsessive Passion (OP), the Big Five traits, the Dark Triad traits, and Psychological Safety (PS). Due to reliability concerns, only OP and the Dark Triad traits could be used to assess the MTurk sample. Results from regression analysis showed that among MTurk …

The 2015 Ncaa Cost-Of-Attendance Stipend And Its Effects On Institutional Financial Aid Packages, Sara Greene

Honors Theses

In 2015, the National Collegiate Athletic Association (NCAA) allowed “Cost of Attendance” (COA) stipends to be offered to athletic recruits for Division I schools. These stipends are intended to allow schools to grant aid to student-athletes beyond a full-ride scholarship to cover additional costs imposed on student-athletes. These stipends created an opportunity for the “Autonomy” Power 5 programs to utilize a competitive tactic to try to win over the top recruits. There is evidence that these COA stipends have caused an increase in the estimated cost of attendance reported by the university. This paper examines if the COA stipends have …

The Parental Labor Gap: The Impact Of Daycare Access On The Parental Labor Force During The Covid-19 Pandemic, Acacia Wyckoff

Honors Theses

In the two years since the COVID-19 pandemic began, the landscape for work has shifted dramatically. Many companies and employers switched to telework when the pandemic hit, and many still do not require workers to come into the office. Research suggests these COVID-induced changes have led to a closing of the gap in childcare duties between men and women in households. Comparing parents in positions with telework eligibility versus in-person positions, Heggeness and Suri (2022) found that while telework improved the labor participation rate of mothers slightly, there was still a major gap in labor force participation between mothers and …

Vietnam’S Gdp: Re-Assessing Growth Rate And Identifying An Alternative Indicator, My Linh D. Nguyen

Honors Theses

Since the economic reform known as Doi Moi (Renovation) in 1986, Vietnam has changed from one of the world’s poorest to a middle-income country in one generation (USAID, 2022). The country has consistently registered high and stable economic growth since the reform, averaging 6.3% from 1985 to 2021 (World Bank, 2022). High growth rate of gross domestic product (GDP) is good news, but it has also raised questions that go both ways. On one side, there is much speculation that the government of Vietnam has manipulated economic statistics, compared to the case of China and India. As quoted in Kinh …

Esg Reporting And Its Effect On Financial Performance Of Oil, Gas, And Utility Companies In The United States, Logan Lam

Honors Theses

According to the Harvard Business Review article ESG Investing Isn’t Designed to Save the Plant (Pucker and King 2022), the term ESG investments – which stands for environmental, social, and governance investing – often confuses investors because it is unregulated. Additionally, the author continued to claim that the data is outdated and mostly unaudited. Even if data on these investments is available to investors, it can still be challenging for them to make decisions regarding ESG. Trusting compatibility and accuracy can be difficult considering that companies can choose how to produce or calculate their own ESG data. Another claim that …

Breaking Into Bon Air Juvenile Correctional Center: A Lesson In (Non) Quantitative Research, Mackenzie Seward

Honors Theses

Gaps in the literature on juvenile justice and mental health within a juvenile correctional center prompted a study that focused on self-esteem, emotions, and empathy in residents living in a juvenile correctional center related to their participation in a storytelling course. First-year students from a local university visited the correctional center as part of a community-based learning component. They met with residents to swap stories about their lives. Several limitations and obstacles complicated the data collection process, forcing the researchers to pivot their study from quantitative analyses to qualitative observations. The experience of conducting a study within a juvenile correctional …

Dungeons & Dragons: Fractals Of The Human Self, Katie Anderson

Honors Theses

Dungeons & Dragons at its core is roleplay based storytelling, which implies the idea that the game is a work of fiction. While the world of Iad and the Free States of Tarvan does not exist on planet earth, the experiences and emotions felt by the players and their characters within the world are very much real. Players use extensions of themselves, their characters, to interact with the world around them, forging relationships and new lines of fate and destiny. Characters are fractals of their out of game personas, attached to one’s base personality and expanding outwards. The development of …

Constraining H0 Via Extragalactic Parallax, Nicholas Ferree

Honors Theses

We examine the prospects for measurement of the Hubble parameter 𝐻₀ via observation of the secular parallax of other galaxies due to our own motion relative to the cosmic microwave background rest frame. Peculiar velocities make distance measurements to individual galaxies highly uncertain, but a survey sampling many galaxies can still yield a precise 𝐻₀ measurement. We use both a Fisher information formalism and simulations to forecast errors in 𝐻₀ from such surveys, marginalizing over the unknown peculiar velocities. The optimum survey observes ∼ 102 galaxies within a redshift 𝐻₀max = 0.06. The required errors …

Role Of Cdx4 And Sp5l In Zebrafish Development, Wesley Tsai

Honors Theses

The Caudal Type Homeobox transcription factors cdx are a family of genes found in vertebrates that regulates body regionalization and anterior-posterior patterning. They are also responsible for regulating axial elongation, but the mechanisms behind this behavior are not known. Previous studies in mouse embryonic stem cells have shown that the cdx genes are necessary for upregulating the gene sp5 which may be linked to axial elongation. Sp5 is a zinc-finger transcription factor belonging to the specificity protein (sp) family. Our group has used in-situ hybridization experiments on zebrafish embryos to show that sp5-like (sp5l) is transcribed within tailbud tissues that …

Ricucire Il Tessuto Della Società: L’Intersezione Di Moda Femminile E Femminismo, Caroline Grace Bisese

Honors Theses

La moda è tutt'altro che una conseguenza frivola e accidentale dell'abbigliamento disponibile e del luogo in cui si va a fare shopping. L’abbigliamento è una forma di retorica corporea che evoca un ampio dialogo non verbale. Una narrazione che va ben oltre il materiale e lo stile, sebbene entrambi questi dettagli sono fondamentali, la moda al livello più elementare è essenziale per capire chi sono le persone, perché sono come sono e in cosa credono. Queste sono alcune dei capisaldi per capire una persona in relazione alla cultura e una cultura in conseguenza delle persone che la compongono. È una …

Understanding And Addressing Disparities In Kidney Transplantation Access: A Focus On Disability And Other Identities, Razan Khalil

Honors Theses

The global prevalence of chronic kidney disease (CKD) is estimated to be between 8.7% and 18.4% (Samuels et. al, 2022), with approximately 843.6 million Americans having been diagnosed with one of the 5 stages of CKD in 2022 (Kovesdy, 2022). As of 2021, 1 in 7 adults were affected, which was about 37 million Americans according to the Centers for Disease Control and Prevention (CDC, 2021). CKD is a long-term condition in which the kidneys gradually lose function, leading to a buildup of waste and fluids in the body. This can result in a variety of symptoms, including high blood …

“Nails Done, Hair Done, Everything Did!”: Consumption And The Creation Of Black Feminine Selves, Simone Reid

Honors Theses

This thesis examines how race and gender shape the meaning that Black women associate with their beauty consumption practices and spending. Much of the existing feminist scholarship on beauty has been postfeminist, privileging the concept of agency and empowerment over structural realities. However, the materialist feminist frame has more utility to address how beauty operates within the lives of Black women as a form of distinct gendered racial oppression. The concept of aesthetic capital emerges from the materialist feminist perspective and suggests that beauty demands the investment of considerable economic resources and can deliver economic returns. Despite this, aesthetic capital …

Food Related Intrusive Thoughts: A Pilot Study, Hoor Ul Ain

Honors Theses

Food related intrusive thoughts (FRITs), a type of intrusive thoughts, might be associated with greater frequency of food intake, greater anxiety and distress, and negative affect in general. However, little is known about the experience of FRITs in the moment. I hypothesized that (1) momentary food related intrusive thoughts or FRITs would be positively related to momentary negative affect and (2) that time since eating will moderate this relationship such that people with more time since eating will show a stronger positive relationship between FRITs and negative affect. These relationships were not found to be significant; however, there was a …

Debt And The Medicare Eligibility Discontinuity: Disparate Effects Across Households, Olivia Falck

Honors Theses

Public health insurance programs like Medicare and Medicaid have been shown to help reduce household debt caused by healthcare costs. The impact of health insurance literacy makes the relationship between public health programs and debt more ambiguous. The increasing complexity of Medicare raises the question of whether cost savings associated with enrollment might be mitigated by the complexity of choosing the ideal plan for those with low health insurance literacy. In this study, I utilize the Medicare eligibility cutoff at age 65 to implement a regression discontinuity design that analyzes the impact of Medicare eligibility on household debt and out …

Study Of Missing Mass Background In The Clas12 Detector, Jessie Hess, Gerard P. Gilfoyle, Lamya Baashen

Honors Theses

At Jefferson Lab we use the CLAS12 detector to measure the neutron magnetic form factor. An accurate measurement of the CLAS12 neutron detection efficiency (NDE) is required. We use the nuclear reaction ���� → ��′��+�� as a source of tagged neutrons and obtain the NDE from the ratio of expected neutrons to detected ones. We assume the final state consists of ��′��+�� only, use the ��′��+ information to predict the neutron's position(expected) and then search for that neutron(detected). We select neutrons with the missing mass (MM) technique. We use simulation to validate our methods. We simulated events with the Monte-Carlo …

Care Or Compliance? An Examination Of Sexual Violence And Institutional Responses At Two Crisis Points, Sophia Hartman

Honors Theses

Understanding the existence of sexual violence requires an investigation of the actions and contexts that either permit or prevent this form of violence. There exists a desire to draw a strict line between adolescence and adulthood, especially in relationship to sexual engagement, and in particular its implications for sexual violence. Utilizing Urie Bronfenbrenner’s Bioecological Model of Human Development and the concept of sexual citizenship—one’s right to sexual self-determination as well as the equivalent right of others—this thesis evaluates the perpetuation of sexual violence within the contexts of two crisis points. First, the moral panic during the Progressive Era surrounding female …

Why Diversity Is Not Enough: Perceptions Of University Diversity, Equity, And Inclusion Initiatives Predict Institutional Belonging, Mckennah Lauber

Honors Theses

Belonging, including feelings of being valued in a larger institutional space, is important to student overall well-being. For students of color attending Primarily White Institutions (PWIs) (and other historically marginalized group members), institutional belonging maybe partially dependent on how they perceive diversity, equity, and inclusion (DEI) initiatives. This study aims to assess individual differences in how DEI initiatives are experienced by students at PWIs in order to better understand how experiences of DEI initiatives on campuses may differentially impact students of color compared to White students. Belonging for students of color was found to be contingent on their perceptions of …

Electrochemical Reduction Of Carbon Dioxide Using Ruthenium And Amines, Sydney Moise

Honors Theses

With an increased concern for climate change in the recent years, a significant area of research has been devoted to the reduction of greenhouse gases. Carbon dioxide (CO2) resides in the atmosphere between 300 – 1000 years, making the reduction of the molecule a substantial field of study.1 Amines have been used as CO2 scrubbing agents in literature historically, due to their ability to form bonds to carbon.2 Although studies involving metal catalysts and amines have been reported numerous times, research involving chemical reduction of CO2 using purely amines is scarce. In this paper, amines, in addition to hydride donors …

Taking The Social Out Of Social Media: Social Media Induced Loneliness As A Mechanism For Elevated Depression During The Pandemic, Samara Rosen

Honors Theses

During the COVID-19 pandemic health protocols limited in-person interactions, interrupting the undergraduate experience and prompting students to find virtual ways to connect with their peers. A key goal of this study was to assess whether college students’ social media use was a viable replacement for in-person interactions during the pandemic, reducing risk for psychological difficulties that ordinarily accompany social isolation. The purpose of the present study was to evaluate loneliness as a potential mediator underlying the longitudinal relationship between social media use and depression. Self-report data were collected in November 2020 (T1), February 2021 (T2), and May 2021 (T3). The …

Maladaptive Social Cognitions And Peer Victimization In Elementary-Aged Students, Katelyn Szarko

Honors Theses

Among elementary-aged students, peer victimization is common and is associated with psychological maladjustment and poor academic achievement. Students with maladaptive social cognitions, like low social competence and low perceived control, are more likely to be victimized, but having a supportive teacher and/or a positive classroom climate might help to mitigate this association. This study aimed to answer the question of whether teacher support and classroom climate protect against peer victimization for students with maladaptive social cognitions. It was hypothesized that teacher support and classroom climate will separately moderate the link between social competence/perceived control and subsequent peer victimization such that …

Policy Design And The Lived Experience Of The Poor: A Test Of Policy Feedback Effects And Efficacy, Ava Gural

Honors Theses

As American political actors have framed poverty as a choice made by the unambitious, it has become clear that our society has a pervasive misunderstanding of poverty. Policy Feedback Theorists assert that the design of our welfare policies contributes to this fallacy, raising the question of whether there is a relationship between policy design and the way citizens act and feel. This thesis uses quantitative data from the American Citizen Participation Study and qualitative data from two original interviews to test the existence of “policy feedback effects” on program participants’ feelings of efficacy. Quantitative evidence suggests limited evidence of policy …

“... I Thought You Were Black .” An Autoethnographic Exploration Of The Fragmentation Of Identity And Culture., Sherley Arias-Pimentel

Honors Theses

"If anthropology doesn't break your heart, then you're not doing it right." - Ruth Behar Writing this thesis has been a trying experience. Within these pages, you will find the therapeutic expedition of a caramel-colored, Spanish-speaking, second-generation black Dominican woman from Newark, NJ who took advantage of this research opportunity to better understand the racial and ethnic parts of her identity which have caused her much turmoil and low self-esteem. Centering myself, my identity, and my story in this research and grappling with the complexities of the subject matter has been an exhausting yet liberating experience. I have contemplated many …

A Necessary Evil: A Leadership Analysis Of Major League Baseball’S Best Managers, Samuel Shapiro

Honors Theses

This study aims to contribute to the literature assessing the success of baseball managers relative to the context that governed their roles. More specifically, it seeks to address the presence of universal leadership styles, traits, and characteristics that have persisted across different eras and contexts.