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Understanding The Structural Basis Of Sike Interactions, Alice Catalano
Understanding The Structural Basis Of Sike Interactions, Alice Catalano
Honors Theses
Tank Binding Kinase 1 (TBK1) acts as a catalytic hub in the regulation of numerous immune signaling pathways. Suppressor of IκB Kinase ε (SIKE) was recently characterized as a substrate of TBK1 whose binding properties are modulated by phosphorylation state, but very little is currently known about its function. However, because SIKE is known to form a dimer with itself, previous work generated a list of potential SIKE partners based on other proteins that contain sequences homologous to SIKE. Here, computational models of four potential SIKE partners, Heavy Chain myosin, tubulin, Beta Catenin and Ezrin, were generated and docked with …