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Articles 1 - 4 of 4
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Registration And Recognition In 3d, Alexander Evans Patterson Iv
Registration And Recognition In 3d, Alexander Evans Patterson Iv
Publicly Accessible Penn Dissertations
The simplest Computer Vision algorithm can tell you what color it sees when you point it at an object, but asking that computer what it is looking at is a much harder problem. Camera and LiDAR (Light Detection And Ranging) sensors generally provide streams pixel of values and sophisticated algorithms must be engineered to recognize objects or the environment. There has been significant effort expended by the computer vision community on recognizing objects in color images; however, LiDAR sensors, which sense depth values for pixels instead of color, have been studied less. Recently we have seen a renewed interest in …
Regulating Gene Expression With Light-Activated Oligonucleotides, Julianne C. Griepenburg
Regulating Gene Expression With Light-Activated Oligonucleotides, Julianne C. Griepenburg
Publicly Accessible Penn Dissertations
The work in this thesis identifies new photochemical approaches to gain high spatiotemporal control over molecular structure and function, for broad applications in materials and biological science. "Caged" compounds provide a method for temporarily blocking function until acted upon by an external trigger, typically near-UV light. To enable multiplexing studies, three new biomolecular caging strategies were developed that can be activated with various wavelengths of near-UV or visible light. The first method, an oligonucleotide hairpin structure incorporating one or two nitrobenzyl photolinkers, was applied to a miRNA antagomir and used to "turn off" let-7 miRNA in zebrafish embryos with 365 …
Mechanisms Of Non-Canonical Nf-Kappab Regulation, Carolyn Margaret Gray
Mechanisms Of Non-Canonical Nf-Kappab Regulation, Carolyn Margaret Gray
Publicly Accessible Penn Dissertations
NF-kappaB is activated through two signaling cascades: the classical and non-canonical pathways, which are distinguished based on the Inhibitor of kappaB Kinase (IKK) components required to activate each pathway. Whereas classical NF-kappaB requires NF-kappaB Essential Modulator (NEMO) and IKKbeta, non-canonical NF-kappaB requires IKKalpha and upstream stabilization of NF-kappaB Inducing Kinase (NIK), but not NEMO. However, we have previously shown that IKKalpha contains a functional NEMO binding domain and associates with NEMO and IKKbeta as part of the heterotrimeric IKK complex. The overarching goal of the work described in this thesis was to determine whether the interaction between NEMO and IKKalpha …
Systemic Incongruity: Bringing Down The Risks Of Conformity And Deviation Biases, Shefali V. Patil
Systemic Incongruity: Bringing Down The Risks Of Conformity And Deviation Biases, Shefali V. Patil
Publicly Accessible Penn Dissertations
Employees often have to decide whether to conform to or deviate from the status quo. Exhibiting consistent preferences for either preserving or maintaining the status quo (i.e., conformity biases) or for challenging or rejecting the status quo (i.e., deviation biases) can be costly. Conformity biases prevent employees from adapting to changing task demands and deviation biases hamper the predictability and reliability of decisions. It is therefore important for scholars and practitioners to understand how to engineer work environments that, to the degree possible, enable employees to bring down both types of risks. However, our understanding of this issue is limited …