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2-arachidonyl glycerol, alpha-synuclein, arachidonic acid, brain lipid metabolism, neuroinflammation, prostaglandins
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The Role Of Α-Synuclein In Brain Lipid Metabolism And Inflammation, Drew R. Seeger
The Role Of Α-Synuclein In Brain Lipid Metabolism And Inflammation, Drew R. Seeger
Theses and Dissertations
Alpha-synuclein (Snca) is a small cytosolic protein that is ubiquitously expressed in the nervous system and comprises 0.5-1% of all cytosolic protein, but its biological function is poorly understood. Although Snca function has been studied in lipid metabolism, the function of Snca in brain lipid metabolism under inflammatory conditions is yet to be elucidated. We utilized several model systems including primary cultured astrocytes and microglia, Snca deficient and mutant knock-in mice, and a radiolabeled free fatty acid steady state-kinetic mouse model to determine Snca role in neuroinflammation. Herein, we have determined several major roles of Snca during inflammation: (i) dBcAMP …