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Molecular Mechanism Of Autophagy-Based Unconventional Secretion Of Il-Β, Shanya Jiang
Molecular Mechanism Of Autophagy-Based Unconventional Secretion Of Il-Β, Shanya Jiang
Biomedical Sciences ETDs
Proteins without signal peptides can still be released into extracellular space via ER/Golgi-independent unconventional secretory pathway(s) that remain to be revealed. A class of leaderless proteins including the pro-inflammatory cytokine interleukin-β (IL-β) is processed in the cytosol by proteolytic machineries such as the inflammasome prior to secretion. Studies in yeast uncovered a new unconventional secretory pathway that is dependent on GRASP (Golgi Reassembly and Stacking Protein) and autophagy proteins. The purpose of this work was to determine whether this autophagy-based unconventional secretory pathway (secretory autophagy) is conserved in mammals, how this secretory autophagy differs from the traditional degradative autophagy, and …
The Early Time Course Of Autophagy In Human Peripheral Blood Mononuclear Cells Following Endurance Exercise, Kathryn Lanphere
The Early Time Course Of Autophagy In Human Peripheral Blood Mononuclear Cells Following Endurance Exercise, Kathryn Lanphere
Health, Exercise, and Sports Sciences ETDs
Exercise disrupts homeostasis and leads to the induction of an important catabolic system called autophagy. Autophagy is a beneficial cell survival process that is induced in periods of starvation. The purposes of this study are to (1) determine the time course of autophagy activation following endurance exercise at 70% of VO2max in a warm environment and (2) to determine if exercising at 50% of VO2max induces autophagy in a warm environment. Methods. Eight endurance trained subjects (2 females) participated in this study and completed a moderate intensity exercise (MIE) trial for 1h (50% of VO2max ), and a high intensity …