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Fetal Alcohol Spectrum Disorder-Associated Depression: Evidence For Reductions In The Levels Of Brain-Derived Neurotrophic Factor In A Mouse Model, Kevin Caldwell, S. Sheema, Rodrigo D. Paz, Sabrina Samudio-Ruiz, Mary Laughlin, Nathan Spence, Michael Roehlk, Sara Alcon, Andrea Allan
Fetal Alcohol Spectrum Disorder-Associated Depression: Evidence For Reductions In The Levels Of Brain-Derived Neurotrophic Factor In A Mouse Model, Kevin Caldwell, S. Sheema, Rodrigo D. Paz, Sabrina Samudio-Ruiz, Mary Laughlin, Nathan Spence, Michael Roehlk, Sara Alcon, Andrea Allan
Undergraduate Medical Student Research
Prenatal ethanol exposure is associated with an increased incidence of depressive disorders in patient populations. However, the mechanisms that link prenatal ethanol exposure and depression are unknown. Several recent studies have implicated reduced brain-derived neurotrophic factor (BDNF) levels in the hippocampal formation and frontal cortex as important contributors to the etiology of depression. In the present studies, we sought to determine whether prenatal ethanol exposure is associated with behaviors modeling depression, as well as with reduced BDNF levels in the hippocampal formation and/or medial frontal cortex, in a mouse model of fetal alcohol spectrum disorder (FASD). Compared to control adult …