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Targeted Gene Replacement To Mimic Familial Hypertrophic Cardiomyopathy In Caenorhabditis Elegans, Craig Alan Almeida
Targeted Gene Replacement To Mimic Familial Hypertrophic Cardiomyopathy In Caenorhabditis Elegans, Craig Alan Almeida
Doctoral Dissertations
The identification in invertebrates of genes homologous to human disease genes provides the possibility to broaden the spectrum of model organisms to include experimental invertebrates. The goal of this study is to test the possibility of using Caenorhabditis elegans as an animal model for the inherited human heart disorder familial hypertrophic cardiomyopathy. In 10-30% of the affected families that have been studied, this disease is caused by mutations in the $\beta$-cardiac myosin heavy chain (MHC) gene. The most common of these mutations results in the replacement of an evolutionarily conserved arginine residue (R403) with glutamine (R403Q). While this information has …
Relationship Of Critical Photoperiod Of Short-Day Parents To Frequency Of Day-Neutral Progeny In Short-Day X Day-Neutral Crosses Of Fragaria X Ananassa, Christina Marie Cundari
Relationship Of Critical Photoperiod Of Short-Day Parents To Frequency Of Day-Neutral Progeny In Short-Day X Day-Neutral Crosses Of Fragaria X Ananassa, Christina Marie Cundari
Doctoral Dissertations
Critical photoperiod for flowering was determined for short-day (SD) and day-neutral (DN) genotypes of strawberry used in SD x DN crosses to investigate whether variation in critical photoperiod contributes to variation in frequency of DN progeny and, hence, may be an effective selection criterion for screening SD genotypes for use as parents in breeding regionally-adapted DN cultivars. Twelve SD and four DN genotypes were grown in controlled environments under eight photothermal regimes (four photoperiods (9, 11, 13, 15 hr) x two day/night temperatures (19/14 and 24/19$\sp\circ$C)). Among the SD genotypes, critical photoperiod varied more under cool than warm regimes. Under …
Variation In Transposable Element Sequence And Activity In The Nematode Caenorhabditis Elegans, Jeremy David Glasner
Variation In Transposable Element Sequence And Activity In The Nematode Caenorhabditis Elegans, Jeremy David Glasner
Doctoral Dissertations
Eukaryotic genomes are replete with transposable elements. The nematode C. elegans will be the first multicellular organism to have its genome completely sequenced. This sequence will allow identification of all the transposon and transposon-related sequences from a single genome. In anticipation of the complete genome sequence I have initiated a series of analyses of sequences from the C. elegans genome database that share significant similarity to known families of transposons. Several members of known transposon families were observed along with a plethora of sequences related to these known transposons. Cladistic analyses were used to describe the relationships among transposons and …
Patterns Of Base Composition Within And Between Animal Mitochondrial Genomes, Nicole T. Perna
Patterns Of Base Composition Within And Between Animal Mitochondrial Genomes, Nicole T. Perna
Doctoral Dissertations
Nucleotide composition of a DNA molecule is a product of base substitution. Variation in nucleotide composition indicates a change in the pattern of substitution at either the level of the underlying mutational spectrum or the constraints imposed by natural selection. This work explores patterns of nucleotide usage within and between animal mitochondrial genomes and the evolutionary mechanisms that have shaped these patterns. Fourfold degenerate sites are expected to reflect the underlying mutational spectrum. Three simple measures of compositional bias, taking into account the strand-specific nature of nucleotide distribution in mtDNA, reveal considerable variation among fourfold degenerate sites of metazoan mitochondrial …