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Interactions Of Conjugated And Unconjugated Bile Salts With Model Phospholipid Membranes: Vibrational Spectroscopic Studies, Kimberly Ann Parthum
Interactions Of Conjugated And Unconjugated Bile Salts With Model Phospholipid Membranes: Vibrational Spectroscopic Studies, Kimberly Ann Parthum
Doctoral Dissertations
Bile salts play important roles in digestion and the treatment of diseases. Few studies have been performed to determine, at the molecular level, the interactions of individual bile salt species with cellular membranes. Vibrational spectroscopy provides a noninvasive approach for characterizing the structural changes occurring within the lipid matrix due to their association with bioactive molecules. The frequency of the methylene stretching modes in the infrared spectra of the lipids comprising the membrane, as a function of temperature, yields information on the intra- and interchain order/disorder of the lipid matrix, the stability of the membrane, and the cooperativity between lipid …
Investigation Of Pd(A)(20)Pd(T)(20) In The Analytical Electrophoresis Apparatus, John Oliver Wooll
Investigation Of Pd(A)(20)Pd(T)(20) In The Analytical Electrophoresis Apparatus, John Oliver Wooll
Doctoral Dissertations
The analytical electrophoresis apparatus (AEA) is capable of generating and monitoring the electrophoretic migration of macroions. The oligonucleotide pd(A)$\sb{20}\cdot$pd(T)$\sb{20}$ was use as a model to compound to evaluate the range and validity of AEA measurements under a variety of electric fields and solvent conditions. A broad range of electric fields yield consistent, reproducible values. The charge determination from different procedures, steady state electrophoresis (SSE) and electrophoretic mobility, have not been consolidated into a consistent theory but advancements in the scope and understanding of the AEA's potential have been made. The apparent charge from the AEA measured electrophoretic mobility, $\mu$, of …