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Evaluation Of Polymer Coated Attenuated Total Reflection (Atr) Elements For The Analysis Of Organic Compounds In Aqueous Solution, Marc C. Ertan-Lamontagne
Evaluation Of Polymer Coated Attenuated Total Reflection (Atr) Elements For The Analysis Of Organic Compounds In Aqueous Solution, Marc C. Ertan-Lamontagne
Doctoral Dissertations
A significant limitation of ATR/FTIR for the analysis of aqueous solutions is the relatively high bulk concentration of analyte required. One approach to improving the detection of an analyte is to incorporate a thin polymeric phase at the surface of the ATR element. The purpose of the polymeric phase is to extract the analyte of interest and concentrate it within the depth of penetration of the evanescent wave. Utilizing a very high molecular weight poly(vinyl chloride) phase the time necessary to reach equilibrium for a 0.05% (v/v) nitrobenzene in a 1.5% (w/v) methanol/water solution was over 60 minutes. A study …
Chiral Separations Using Bile Salts In Capillary Electrophoresis, James George Clothier
Chiral Separations Using Bile Salts In Capillary Electrophoresis, James George Clothier
Doctoral Dissertations
Micellar electrokinetic capillary chromatography (MECC) using surfactant solutions containing bile salts, polyoxyethylene ethers and methanol was used to produce chiral separations. A capillary electrophoresis instrument was assembled in the laboratory. Initial testing and optimization of the instrument involved the separation of organic acids using capillaries zone electrophoresis techniques. Polymer coated capillaries were prepared and tested in the instrument. Bile salt solutions were characterized by viscosity and nuclear magnetic resonance. The effects of various solution conditions, such as pH, ionic strength and concentration of bile salt solutions on chiral resolution were investigated by MECC. Enhancement in chiral resolution was obtained using …