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Cross-Reactivity Between Major Histocompatibility Complex Antigen And Rous Sarcoma Virus-Induced Tumor Antigen In Chickens, Eric Warren Heinzelmann
Cross-Reactivity Between Major Histocompatibility Complex Antigen And Rous Sarcoma Virus-Induced Tumor Antigen In Chickens, Eric Warren Heinzelmann
Doctoral Dissertations
Cross-reactivity between major histocompatibility complex (MHC) antigen and Rous sarcoma virus (RSV)-induced tumor associated antigen (TAA) in chickens was investigated. The B erythrocyte allcantigen locus was the genetic marker for the MHC. B2B2 and B5B5 chickens from crosses of highly inbred lines 6-1 and 15-1 and B24B24 chickens from noninbred line UNH 105 were used.
B2B2 chickens rendered partially tolerant to B5 antigen through multiple intraperitoneal inoculations of either viable or lysed white blood cells (WBC) or viable red blood cells (REC) from B5B5 chickens had a significantly higher incidence of tumor progression than untreated, phosphate buffered saline treated, or …