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Evaluation Of Photodynamic Therapy-Induced Edema In The Rat Brain Using Magnetic Resonance Imaging, David Chighvinadze

UNLV Retrospective Theses & Dissertations

Failure of treatment for high-grade gliomas is usually due to local recurrence at the site of surgical resection indicating that a more aggressive form of local therapy should be used. Photodynamic therapy (PDT) shows promising results in the treatment of gliomas as it has been shown to cause significant destruction of tumor cells through localized necrosis and/or apoptosis. An unfortunate complication of this therapy is the induction of cerebral edema which causes increased intracranial pressure and associated morbidity. A potential solution is the administration of steroids to reduce PDT-induced edema, associated morbidity, and mortality in treated animals. In the research …