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Deficiency Of Tnf Receptors Suppresses Microglial Activation And Alters The Susceptibility Of Brain Regions To Mptp-Induced Neurotoxicity: Role Of Tnf-Α, Krishnan Sriram, Joanna M. Matheson, Stanley A. Benkovic, Diane B. Miller, Michael I. Luster, James P. O'Callaghan
Deficiency Of Tnf Receptors Suppresses Microglial Activation And Alters The Susceptibility Of Brain Regions To Mptp-Induced Neurotoxicity: Role Of Tnf-Α, Krishnan Sriram, Joanna M. Matheson, Stanley A. Benkovic, Diane B. Miller, Michael I. Luster, James P. O'Callaghan
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Enhanced expression of tumor necrosis
factor (TNF) -α, is associated with the neuropathological
effects underlying disease-, trauma- and chemically
induced neurodegeneration. Previously, we have shown
that deficiency of TNF receptors protects against
MPTP-induced striatal dopaminergic neurotoxicity,
findings suggestive of a role for TNF-α in neurodegeneration.
Here, we demonstrate that deficiency of TNF
receptors suppresses microglial activation and alters
the susceptibility of brain regions to MPTP. MPTPinduced
expression of microglia-derived factors,
TNF-α, MCP-1, and IL-1α, preceded the degeneration
of striatal dopaminergic nerve terminals and astrogliosis,
as assessed by loss of striatal dopamine and TH, …