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Articles 1 - 4 of 4
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Impacts Of Embryonic Exposure To Cannabidiol Or ∆9-Tetrahydrocannabinol On Zebrafish (Danio Rerio) Frailty In F0 And F1 Generations, Anika Faruque
Impacts Of Embryonic Exposure To Cannabidiol Or ∆9-Tetrahydrocannabinol On Zebrafish (Danio Rerio) Frailty In F0 And F1 Generations, Anika Faruque
Honors Theses
Exposure to cannabinoids during critical development periods has increased with epileptic children being commonly prescribed CBD for seizures and pregnant women taking it recreationally. Many studies have been done on the possible benefits and drawbacks of cannabinoid exposure on the human brain, but not much is known about how it can affect the developing brain long-term. To see the potential adverse effects of cannabinoid exposure during critical stages of development and discover potential developmental origins of disease in consuming cannabinoids during embryogenesis, zebrafish embryos (6-96 hours post fertilization) were exposed to varying concentrations of CBD (0.02, 0.1, 0.5 µM), THC …
Multi-Generational Effects Of ∆9-Tetrahydrocannabinol Exposure On Gene Expression In Liver Tissue, Kayla Lovitt
Multi-Generational Effects Of ∆9-Tetrahydrocannabinol Exposure On Gene Expression In Liver Tissue, Kayla Lovitt
Honors Theses
Cannabis is the most commonly used, cultivated, and trafficked illicit drug worldwide. Increased availability and acceptance of cannabis and cannabinoid-containing products provide the necessity for understanding how these substances influence aging. In this study, zebrafish (Danio rerio) were exposed to concentrations of Δ9-tetrahydrocannabinol (THC) (0.08, 0.4, 2 µM) during embryonic-larval development, the effects on aging were measured 30 months later and in the offspring of the exposed fish (F1 generation. We observed results indicating a biphasic and hormetic effect. Treatment with the lowest concentration of THC significantly increased egg production, while higher concentrations resulted in impaired …
Role Of Insulin-Like Growth Factor 1 Receptor In The Regulation Of Astrocyte Structure, Function And Cognition, Disha Prabhu
Role Of Insulin-Like Growth Factor 1 Receptor In The Regulation Of Astrocyte Structure, Function And Cognition, Disha Prabhu
Electronic Theses and Dissertations
Levels of Insulin-like growth factor I (IGF-1) are reduced in several neurological disorders, including aging and neurodegeneration. Aged animals have reduced IGF1 signaling and exhibit impairment in cognition. Supplementing rodents with IGF-1 reverses some of the cognitive deficit, suggesting that IGF-1 signaling could potentially be targeted to ameliorate cognitive decline in older adults. For this, a thorough understanding of the mechanisms by which IGF-1 regulates the function of various cell types in the brain is needed. A majority of studies have focused on the effects of IGF-1 regulating neurons. However, astrocytes that form roughly about 40% of brain mass also …
Behavioral Chronopharmacology Of Cannabinoids In Young And Aged Mice, Erik Lewis Hodges
Behavioral Chronopharmacology Of Cannabinoids In Young And Aged Mice, Erik Lewis Hodges
Electronic Theses and Dissertations
The overarching goal of this research is to explore the biological mechanisms of aging and formulate novel therapeutic approaches to mitigate age-related impairments. The presence and pervasiveness of ~24 hour (circadian) rhythms in molecular and behavioral dynamics suggests that the mechanisms regulating these rhythms are integral to biological aging and possibly amenable to therapeutic interventions. Based on evidence presented in this dissertation, we conclude that the endocannabinoid system is a mediator of both central and peripheral circadian physiology. Additionally, the hormetic pharmacological properties of the synthetic cannabinoid CP55940 suggest that bidirectional modulation of circadian rhythms via cannabinoids is possible. Chapter …