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New Insights In The Regulation Of Mitochondrial Functions And Metabolic Reprogramming By Erbb Receptors In Cancer, Nirav Patel
New Insights In The Regulation Of Mitochondrial Functions And Metabolic Reprogramming By Erbb Receptors In Cancer, Nirav Patel
Open Access Dissertations
Dysregulation of ERBBs signaling has been known to be responsible for several types of tumors including breast, ovary, lung, pancreas, prostate and more. Functions of ERBB receptors are mainly known from its overexpression in cancers. Apart from elevated levels of ERBB receptors, low levels of ERBB signaling also play a crucial role in normal development and maintenance of mammalian organs. However, the role of signaling by the low “normal” levels of ERBB receptors is poorly understood. Altered ERBB signaling has been implicated with several cardiac defects. One of the severe side effects of ERBB2-targeted therapy in breast cancer patients is …
Latent Membrane Protein-1 As A Vacciine Adjuvant, James Termini
Latent Membrane Protein-1 As A Vacciine Adjuvant, James Termini
Open Access Dissertations
Dendritic cells are a promising cell type for immunotherapy due to their potent immunostimulatory potential. Nevertheless, improper maturation may account for the limited efficacy of dendritic cells in immunotherapy clinical trials. Latent Membrane Protein-1 (LMP1) of the Epstein-Barr virus was examined for its ability to mature and activate dendritic cells as a gene-based molecular adjuvant. Dendritic cells were transduced with an adenoviral vector expressing LMP1 under the control of a Tet- inducible promoter. LMP1 was found to mature and activate both human and mouse dendritic cells. LMP1 enhanced in vitro migration of dendritic cells toward CCL19, as well as in …