Digital Commons Network^™

Student Pharmacists’ Emotional Responses And Coping During The Covid-19 Pandemic, Hannah E. Johnson, Deaundre Bumpass, Aric Schadler, Jeffrey Cain

Journal of Wellness

Introduction: Health professions students, including student pharmacists, have been impacted by the coronavirus disease 19 (COVID-19 pandemic) as schools have transitioned to remote learning and cancelled milestone events. During times of crises, media consumption and hobby participation also impact well-being. The adverse emotional responses and coping strategies of student pharmacists amidst the COVID-19 pandemic have not been evaluated, nor have factors that may contribute to emotional responses. The purpose of this study is to determine Doctor of Pharmacy students’ emotional responses and coping precipitated by the COVID-19 pandemic, and the influence of media use, working status, and participation in hobbies. …

Deep Convolutional Neural Networks For Accurate Diagnosis Of Covid-19 Patients Using Chest X-Ray Image Databases From Italy, Canada, And The Usa, Amgad A. Salama, Samy H. Darwish, Samir M. Abdel-Mageed, Radwa A. Meshref, Ehab I. Mohamed

The University of Louisville Journal of Respiratory Infections

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), famously known as COVID-19, has quickly become a global pandemic. Chest X-ray (CXR) imaging has proven reliable, fast, and cost-effective for identifying COVID-19 infections, which proceeds to display atypical unilateral patchy infiltration in the lungs like typical pneumonia. We employed the deep convolutional neural network (DCNN) ResNet-34 to detect and classify CXR images from patients with COVID-19 and Viral Pneumonia and Normal Controls.

Methods: We created a single database containing 781 source CXR images from four different international sub-databases: the Società Italiana di Radiologia Medica e Interventistica (SIRM), the GitHub Database, the …

Consultation/Liaison Psychiatry During Covid-19, Robert Frierson, Steven B Lippmann

The University of Louisville Journal of Respiratory Infections

Consultation/liaison psychiatrists care for people with co-existing medical and psychologic difficulties. The coronavirus pandemic is stressful for patients and their psychiatric caregivers. Patients have lost support systems and harbor fears about exposing family to the virus. COVID-19 sometimes exacerbates previous psychiatric conditions, while diminishing intimacy with physicians. Everyone is oversaturated with COVID-19-related news focusing on rising concerns about the illness and about jobs, school, and housing insecurities.

The psychiatrist maintains a hospital presence despite fear of contracting the disease. Challenges include addressing staff morale, evidencing empathy despite telecommunication devices, and treating anxiety, depression, sleep phobias, post intubation flashbacks, COVID-19-induced cognitive …

Feasibility Of A “Network Of Champions” In Implementing A Program To Address Physician Well-Being, Kerri Palamara, Sara Poplau, Cheryl Rusten, Maria L. Walter, Cynthia D. Smith, Clare Sipler, Susan Hingle, Mark Linzer

Journal of Wellness

Introduction: Healthcare leaders have been challenged to mitigate burnout and foster well-being among physicians. Professional societies are beginning to address this in a systematic manner.

Methods: In 2014, the American College of Physicians (ACP) endeavored to improve well-being for its 160,000 members of internists and trainees through a Well-being Champion (WBC) program based in the majority of its 85 national and international chapters. The program was supported by an evidence-based curriculum, chapter volunteers who served as champions, and in-person and virtual trainings. Training included a 1-2 day program in 2018 and 2019, focused on educating champions on causes …

Combining Community Wastewater Genomic Surveillance With State Clinical Surveillance: A Framework For Sars-Cov-2 Public Health Practice, Ted Smith, Rochelle H. Holm, Ray Yeager, Joseph B. Moore Iv, Eric C. Rouchka, Kevin J. Sokoloski, Daymond Talley, Vaneet Arora, Sarah Moyer, Aruni Bhatnagar

Faculty Scholarship

Study objective: To garner a framework for combining community wastewater surveillance with state clinical surveillance that influence confirmation of SARS-CoV-2 variants within the community, and recommend how the flow of such research evidence could be expanded and employed for public health response. Design, setting, and participants: This work involved analyzing wastewater samples collected weekly from 17 geographically resolved locations in Louisville/Jefferson County, Kentucky from February 10 to November 29, 2021. Genomic surveillance and RT-qPCR platforms were used as screening to identify SARS-CoV-2 in wastewater, and state clinical surveillance was used for confirmation. Main results: The results demonstrate increased epidemiological value …

Sustainable Urban Groundwater Governance In Faisalabad, Pakistan: Challenges And Possibilities., Shahbaz Altaf

Electronic Theses and Dissertations

Groundwater use is high in developing countries, especially in places where municipal water authorities struggle to meet the water demand of their residents. To analyze the interactions between groundwater and piped water in the Global South context, Faisalabad, Pakistan was taken as the case study area. Using the Institutional Analysis and Development framework and Elinor Ostrom’s design principles as analysis tools, formal and informal institutions governing the piped water and groundwater, including their congruence with the social and ecological factors, were explored. The results showed that scarcity of piped water pushed people towards groundwater and the absence of informal and …

First Principle Studies Of The Effects Of Alkali-Metal Intercalation On Structural Transition From Black To Blue Phosphorene And The Adsorption Of N2h4 On Ws2 Layers., Md Rajib Khan Musa

Electronic Theses and Dissertations

A comprehensive density functional theory calculation has been conducted to seek a potential structural transition from black to blue phosphorene layers, with a focus on the roles played by alkali-metal intercalation in black phosphorene/phosphorus. This study reveals that at sufficiently high Li concentration and specific, well-defined configurations, a phase transition from black to blue phosphorene can take place. The Li atoms intercalated in black phosphorene could act as a “catalyst” in the“reactive region” of the lone pair of P atoms, leading to a P-P bond breaking and, subsequently, a local structural transformation from an orthorhombic lattice to an assembly of …

The Association Between Depression And Anxiety With Covid-19 Outcomes., Erica Miller

Electronic Theses and Dissertations

Previous studies have shown that mental disorders affect COVID-19 mortality. This study investigated the effect of depression and/or anxiety on COVID-19 outcomes. Depression/anxiety was defined by actively taking medication and/or diagnosis. The outcomes were ICU admission; ventilation; mortality; and time to mortality. Of 698 hospitalized patients, there were 204 (29%) defined to have either depression or anxiety. There were 109 deaths, and of those, 52 (48%) were diagnosed with depression/anxiety. Multivariable logistic regression and Cox proportional hazards models were used to examine associations. ICU admission and ventilation were not significantly associated with depression/anxiety. Depression/anxiety was associated with mortality (OR: 1.84, …

Assessing Universal Basic Income Proposals: A Comprehensive Analysis Of Established Studies., Zachary Paul Baker

College of Arts & Sciences Senior Honors Theses

The development of welfare within western cultures has become incredibly polarized over the last decades. Propositions for ideas such as Universal Basic Income (UBI) has reemerged into the mainstream conversation, with some lofty promises. What is the credibility of UBI as a welfare policy platform? Do the results of the studies on the effects of cash-transfers show the possibility of UBI as a new national program, or do they reveal issues that highlight major structural problems with UBI? This thesis examines over twenty different studies within various categories of cash-transfers to see the positives and negatives revealed by previous researchers. …

Pyridine Nucleotide Redox Potential In Coronary Smooth Muscle Couples Myocardial Blood Flow To Cardiac Metabolism., Marc Matthew Dwenger

Electronic Theses and Dissertations

The maintenance of myocardial oxygen supply during stress is essential for sustaining cardiac health. Enhancement of coronary blood flow upon increases in myocardial oxygen demand (i.e., hyperemia) relies on regulation of voltage-gated K⁺ (Kv) channels by their intracellular β subunits (i.e., Kvβ proteins). Considering that, Kvβ proteins are aldo-keto reductases (AKRs) and regulate Kv channel gating, we tested the hypothesis that elevation of myocardial oxygen demand modifies intracellular NAD(H) in arterial myocytes. Furthermore, we tested whether the resultant change in the redox state of the pyridine nucleotide pool directly regulates coronary Kv1 channel activity. High-resolution imaging mass spectrometry and …

Exploring Service Provider Perspectives On Facilitators And Barriers To Needle Exchange Program Participation By Females Who Inject Drugs., Tammi Alvey Thomas

Electronic Theses and Dissertations

As the opioid epidemic lingers on across the country, many areas have set up harm reduction strategies such as needle exchange programs (NEPs) to combat the long-term consequences of injection drug use (IDU). Males and females face a plethora of health issues associated with injection drug use such as human immunodeficiency virus (HIV) and hepatitis C. While males comprise the largest portion of the injection drug use population, most research is gender neutral, which makes it difficult to discern issues specifically related to females inhibiting our ability to design interventions and procedures targeted to address their needs. Females require varying …

The Role Of Sphingolipids In Aki And The Progression To Ckd: Potential Therapuetic Targets., Nicholas A. Hoffman

Electronic Theses and Dissertations

Acute Kidney Injury (AKI) is most simply defined as a rapid decline in kidney function over a period of hours to days. There is currently a lack of effective treatment options for patients with AKI, highlighting the need to identify new therapeutic targets. Sphingolipids play a number of roles in different models of AKI, suggesting they could be promising future targets for treating kidney injury. Specifically, sphingosine-1-phosphate (S1P) and its receptors (S1PRs) have been implicated in numerous inflammatory disorders and models of AKI. The purpose of this review is to better characterize the role of S1P receptors in models of …

Ultrafast Magnetic Entropy Dynamics With Time-Resolved Pump-Probe Magneto-Optical Technique., Sahar Goharshenasanesfahani

Electronic Theses and Dissertations

It has been observed that ultrathin films, multilayers, or magnetic nanostructures indicate novel magnetic phenomena that differ profoundly from the respective bulk properties. Besides, because of the broad applications of these magnetic materials in the industry, they are an exciting research area. Hence, investigating the low-dimensional magnetic systems is one of the most active fields in experimental condensed matter physics. Magnetization dynamics can occur over a wide range of time scales (from seconds to femtoseconds). Some of these processes even occur on time scales as short as a few picoseconds (10^-12s) or femtoseconds (10^-15s). Measurement of …

Understanding Wellbeing In Refugee Youth From The African Great Lakes Region., Victory Osezua

Electronic Theses and Dissertations

Young refugees are a vital and growing population in the United States that experience health inequities that make them vulnerable to adverse health outcomes. The health inequities that are evident between refugees and the general population elucidate the disparate power relations between the outcomes of the colonial past and postcolonial present. Although research shows that colonialism and their more recent experience of racism may have adverse long-term impacts on young people's health, it is essential to understand the contexts that shape their wellbeing. While the westernized model of wellbeing focuses on the individual, this study prioritizes the prevention of illness …

Drone Location And Scheduling Problems In Humanitarian Logistics., Zabih Ghelichi

Electronic Theses and Dissertations

Unmanned Aerial Vehicles (UAVs), commonly referred to as drones, are a promising technology for the last-mile delivery of medical and aid items in humanitarian logistics. In emergency scenarios, like disasters, where transportation networks are destroyed and people are stranded, drones can accelerate the delivery of urgently needed items, e.g., food and water, insulin shots and blood pressure pills, to those trapped in the disaster-affected areas. Drones can also provide logistics services in many non-emergency situations by delivering medical items, e.g., vaccine shots and lab specimens, to remote communities and hard-to-access locations. The contribution of using UAVs goes beyond merely having …

"If Fear Wasn't Enough?!": African American Perceptions Of Policing After Breonna Taylor's Unprovoked Death., Moriah Antoinette Bellamy

Electronic Theses and Dissertations

This study investigates how African Americans perceive the racialization process in the criminal justice system following the death of Breonna Taylor. Focusing primarily on police-community relations in Louisville, KY, I find the Breonna Taylor case amplifies preconceived perceptions of race between civilian and non-civilian groups. To test the hypothesis that racialization in the criminal justice system has caused damaging effects on relations between African Americans and police, two virtual focus groups were designed to discuss participants’ experiences with law enforcement. My findings suggest that the racialization process in the criminal justice system negatively skewed African American civilians’ attitudes towards law …

The Impact Of Statin Use On Outcomes Of Diabetic Adult Patients Hospitalized For Community Acquired Pneumonia., Joel Lanceta

Electronic Theses and Dissertations

BACKGROUND: Statins, a class of drugs that treat hyperlipidemia, may have an immunosuppressive effect for patients with community acquired pneumonia (CAP). Retrospective and in vitro studies have suggested an immunomodulatory, antioxidative and anticoagulant effects from statin use in patients with Type 2 Diabetes Mellitus (T2DM) hospitalized for CAP. Prospective studies that have tested any effect of statin therapy on patients with T2DM and CAP have not been found literature. To date, prospective studies showing of the effects statin therapy may have on T2DM patients hospitalized for CAP are not available. METHODS: This dissertation is a secondary analysis using deidentified data …

The Forgotten Ones: A Qualitative Study To Understand The Phenomena Of Medically Disqualified Student-Athletes., Regina Chanel Johnson

Electronic Theses and Dissertations

The purpose of this phenomenological study was to gain a better understanding of the experiences of medically disqualified student-athletes (MDSA) at National Collegiate Athletic Association (NCAA) Division I institutions. This study is significant because few studies have examined MDSAs, yet they present concerns around career-ending injuries. Drawing on the Kübler-Ross Model of Death and Dying (1969) framework, this study examined if MDSAs have faced experiences in stage-like forms such as denial, anger, bargaining, depression, and acceptance. This study called the attention of athletic administrators to examine and develop support resources for this often-overlooked student-athlete group. Over five chapters, this dissertation …

Exploring The Contextual Factors And Decision-Making Process Of Risky Sexual Behavior Among Homeless Adults In Louisville, Kentucky., Sarah C. Van Heiden

Electronic Theses and Dissertations

Homelessness is a complex public health issue; individuals who experience homelessness are said to engage in risky sexual behaviors at an increased rate and experience a higher prevalence of sexually transmitted infection (STI). While the sexual behaviors of homeless adolescents are commonly studied, little is known about the sexual behaviors of the growing population of older adults, or how they make decisions to engage in sex. Three aims guided this research: 1) to describe the sexual behaviors and sexual decision-making process of homeless older adults, 2) to examine how homeless older adults evaluate the outcomes associated with engaging in risky …

How Do Cover Crops Change Soil Health In A No-Till System?, Aysha Kirsten Tapp Ross

Electronic Theses and Dissertations

Nutrient levels and aggregation measurements are currently the most accurate means to measure soil health. It has been suggested that bacterial and fungal communities may prove to be a more accurate measure of soil health. In this study soil microbe communities and nutrient levels were compared in rye cover cropped soils to measure for differences between treatments. Effects between the microbial communities and environmental measurements were also measured within those treatments to test for correlations between soil health measures and microbial communities. The plots were put in a biennial corn (Zea mays L.) and soybean (Glycine max …

Modeling Driver Distraction Mechanism And Its Safety Impact In Automated Vehicle Environment., Song Wang

Electronic Theses and Dissertations

Automated Vehicle (AV) technology expects to enhance driving safety by eliminating human errors. However, driver distraction still exists under automated driving. The Society of Automotive Engineers (SAE) has defined six levels of driving automation from Level 0~5. Until achieving Level 5, human drivers are still needed. Therefore, the Human-Vehicle Interaction (HVI) necessarily diverts a driver’s attention away from driving. Existing research mainly focused on quantifying distraction in human-operated vehicles rather than in the AV environment. It causes a lack of knowledge on how AV distraction can be detected, quantified, and understood. Moreover, existing research in exploring AV distraction has mainly …

The Economic Rationality Of Consumption In The Mycenaean Political Economy And Its Role In The Reproduction Of Social Personae: Modeling Prestige Networks., Devin Alexander Stephens

Electronic Theses and Dissertations

This thesis is a theoretical examination of the economic rationality of consumption as it existed within the Mycenaean political economy. Using a modified paradigm of social network analysis, a semiotic approach is used in the study of identity expression and economic stratification present at three Late Helladic cemeteries. In doing so, the claim that exchange strategies which existed outside of palatial redistribution were present in the Late Helladic was substantiated as a similar logic of mortuary stratification which existed during the palatial era was also found to have existed after the shift to the post-palatial era and the collapse of …

Investigations Of Potential Mechanisms Underlying Spinal Cord Injury-Induced Polyuria., Jason H. Gumbel

Electronic Theses and Dissertations

Spinal cord injury (SCI) results in neurological impairments including motor, sensory, and autonomic dysfunction. These neurological deficits result in a litany of complications apart from muscular paralysis, including bladder, bowel, cardiovascular, and sexual function. SCI-induced polyuria (the overproduction/passage of urine) remains understudied, and therefore mechanisms behind it are largely unknown and require extensive investigation for potential targeted therapies to improve quality of life. The objective of this dissertation was to investigate potential mechanisms of SCI-induced polyuria and explore potential therapies to improve quality of life in the SCI population. Metabolic cages, Western blot, enzyme-linked immunoassay, and immunostaining were first used …

Black Codes Re-Envisioned: The Dred Scott Majority Opinion As An Antiblack Performative Speech Act., Tiffany Dillard-Knox

Electronic Theses and Dissertations

This dissertation is a discursive analysis of the decision in the Dred Scott v Sandford, 1857 case written by Chief Justice Roger Taney. It begins with an overview of the literature on performative speech acts, focusing on the aspects of performatives that relate to Louis Miron and Jonathan Xavier Inda’s thesis that race is a performative speech act. Breaking from their use of race as the analytic, this analysis is situated within a black/nonblack paradigm. This provides a framework that focuses on the unique ways in which the discourse of the text enacts, accumulates and renders blackness fungible. The …

A Method For Identifying Ancient Introgression Between Caballine And Non-Caballine Equids Using Whole Genome High Throughput Data., Kalpani De Silva

Electronic Theses and Dissertations

Introgression is one of the main mechanisms that transfer adapted alleles between species. The advantageous variants will get positively selected and retained in the recipient population while rest of the variants undergo negative selection. When analyzing horse genome, two alleles were found in CXCL16 gene, one associated with susceptibility and one with resistance to developing persistent shedding of the Equine Arteritis Virus. The two alleles differ by 4 non-synonymous variants in exon 1 of the gene. Comparison with 3 non-caballine equids (zebras, asses and hemiones) revealed that one haplotype was almost identical to the haplotype found in non-caballines while the …

An Investigation Into Energy-Material Properties Interaction In Additive Manufacturing Of Polymers., Pu Han

Electronic Theses and Dissertations

Additive manufacturing (AM), known as three-dimensional (3D) printing, is a fabrication process to build 3D objects layer by layer based on computer aided design (CAD) model or digital 3D model. Fused filament fabrication (FFF) has become a preferred method for additive manufacturing due to its cost-effectiveness and flexibility. However, the parts built using FFF process suffer from lower mechanical strength compared to that fabricated using traditional method and rough surface finish. With this motivation, this dissertation aims to develop and implement a novel in-process laser assisted technique on FFF to heal the microstructure of FFF built objects by enhancing reptation …

Digital Design And Thermomechanical Process Simulation For 3d Printing With Abs And Soyhull Fibers Reinforced Abs Composites., Saleh Khanjar

Electronic Theses and Dissertations

Recent demonstrations with fused filament fabrication (FFF) 3D printing have shown to produce prototypes as well as production components. Additionally, due to the FFF process platforms being low-cost and readily available there has been a high-demand to produce on-demand parts for various applications in automotive, in-space manufacturing and electronic industries. However, current limitations such as limited availability of advanced composites materials, and guidelines for design-for-manufacturing make the process prone to trial-and-error experiments both at the materials development, product design and manufacturing stage. In this work, new thermomechanical process simulations platform, Digimat-AM has been evaluated to address and demonstrate digital design …

Materials And Process Design For Ceramic Fused Filament Fabrication (Cf3) Of Hydroxyapatite., Kavish Sudan

Electronic Theses and Dissertations

Ceramic fused filament fabrication (CF3) enables the fabrication of highly customizable ceramic parts at relatively lower costs compared to other AM technologies. Advanced ceramics, having specific or niche applications, call for a high level of accuracy to meet the performance requirements. For achieving the desired level of accuracy in any manufacturing process, it is important to know the effect of involved parameters at different stages of fabrication. CF3 has been around for a while but there has been a severe lack of literature dealing with understanding the effect of process parameters on the final part properties. In this study, Hydroxyapatite …

Part-Time., Anthony Mark Piedmonte

Electronic Theses and Dissertations

This thesis is a creative writing project in prose covering the first 70 pages of a novel manuscript titled Part-time. Part-time will center around a 25-year-old medical school dropout starting a new job at a neighborhood golf clubhouse and gym. This coming-of-age narrative follows Danny as he struggles with his sexual identity, student debt, and job outlook after returning to the privileged community he grew up in. This sample will introduce the major characters, the clubhouse setting, and the forming relationship dynamics. By the end of these pages, readers will gain insight into how the part-time employees of the Longwood …

Analyzing The Non-Isothermal Multiphasic Flow In Porous Media Through Strongly Coupled Thermo-Hydro-Mechanical Modeling., Mohammadreza Mir Tamizdoust

Electronic Theses and Dissertations

Underground geo-structures and climate change can trigger coupled heat, moisture, and vapor flow in shallow and deep subsurface which is frequently referred to as non-isothermal multiphase flow. The coupled multiphasic flow in soil may induce volumetric shrinkage or expansion deformation depending on the thermo-hydraulic loading condition. In saturated porous media, temperature gradient and heat transfer may affect pore fluid pressure and/or pore fluid flow depending on thermal, mechanical, and hydraulic properties of the media and the saturating fluid. In vadose zones, the prediction of coupled nonisothermal multiphase flow in porous media has been the subject of many theoretical and experimental …