Digital Commons Network^™

Design Of A 300cm2 Pemfc Stack With Force And Cfd Simulation To Optimize Flow Channels, Gasket Design, And Clamping Forces., Robert M. Ench

Electronic Theses and Dissertations

Proton exchange membrane fuel cells are important to the future of green energy as hydrogen can be made with green technologies and store energy for later use. Fuel cells can efficiently convert the hydrogen to electricity as needed. This study uses Solidworks simulation to make design improvements to the fuel cell before the prototype build stage of testing; this saves money and time by reducing the prototype builds needed.

In this study, a multi-channel serpentine design with two outlets versus a single outlet is evaluated using CFD to investigate pressure drop. Lower pressure drops are desirable as less energy input …

Refinement And Automation Using Algorithmic Control Of Breathforce, A Respiratory Training System For Patients With Spinal Cord Injuries., Anna Goestenkors

Electronic Theses and Dissertations

Spinal cord injuries (SCI) can lead to impaired respiratory and cardiovascular function and a general decrease in lung compliance. This can complicate breathing as well as impair the ability to sigh, cough, and clear secretions, leading to increased risk of respiratory infections. Respiratory training has been shown to combat these effects. BreathForce is under active development to create a user-centric inspiratory-expiratory device that is an affordable option for at-home training. This study reports on the refinement of valve design and automation incorporated into BreathForce to enhance and enforce clinical practices and processes as part of the respiratory training protocol used …

Cfd Analysis Of Acoustofluidic Channels And The Effects On Biologic Delivery., Zachary T. Long

Electronic Theses and Dissertations

T-cell transformation is an ever-expanding treatment for several types of cancer, with a potential to be adapted to other disorders in which the immune system plays a key role in the pathophysiology. Currently, all FDA approved chimeric antigen receptor (CAR) T-cell cancer therapies rely on transformation via viral transduction. However, viral transduction is plagued by poor consistency and the potential to create adverse immune reactions when T-cells are reintroduced into a patient. Other transformation methods are being explored, with an alternative called acoustofluidic sonoporation showing promise. In these procedures, cells are passed through a channel, of the millimeter scale, while …