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Language Ability And Concurrent Predictors Of Pragmatic Communication In Children With Williams Syndrome Or 7q11.23 Duplication Syndrome., Amanda G. Harmon
Language Ability And Concurrent Predictors Of Pragmatic Communication In Children With Williams Syndrome Or 7q11.23 Duplication Syndrome., Amanda G. Harmon
Electronic Theses and Dissertations
The present project examined the language abilities of children with two reciprocal neurogenetic disorders: Williams syndrome (WS), which is caused by a hemideletion of 26 - 28 genes on chromosome 7q11.23, and 7q11.23 duplication syndrome (Dup7), which results from an extra copy of the same 26 - 28 genes. Appraising the language of children with WS and Dup7 helps in understanding the communication difficulties they encounter. There were three research goals. The first was to determine the overall level of language and communication ability as measured by the Children’s Communication Checklist-2 (CCC-2; Bishop, 2006) for each syndrome, relative to chronological …
The Use Of Nanoparticles And Electrospun Fibers For Intravaginal Delivery To Treat Viral And Bacterial Infections And Electrophysiological Measurements Of Synthetic Chloride Channels., Farnaz Minooei
Electronic Theses and Dissertations
Female reproductive viral and bacterial infections affect millions of women worldwide. Given the diversity and magnitude of these unmet reproductive health challenges, topical administration of antiretrovirals (ARVs) and antibiotics have emerged as promising approaches to maintain and restore reproductive health. However, currently available intravaginal dosage forms often suffer from low user adherence and the need for frequent, daily administration to achieve therapeutic effect. To address these challenges, the broad goal of this research was to focus on the development of new localized nanoparticle (NP) and electrospun fiber dosage forms to prolong the delivery and enhance the efficacy of active agents …
Exploring Information For Quantum Machine Learning Models, Michael Telahun
Exploring Information For Quantum Machine Learning Models, Michael Telahun
Electronic Theses and Dissertations
Quantum computing performs calculations by using physical phenomena and quantum mechanics principles to solve problems. This form of computation theoretically has been shown to provide speed ups to some problems of modern-day processing. With much anticipation the utilization of quantum phenomena in the field of Machine Learning has become apparent. The work here develops models from two software frameworks: TensorFlow Quantum (TFQ) and PennyLane for machine learning purposes. Both developed models utilize an information encoding technique amplitude encoding for preparation of states in a quantum learning model. This thesis explores both the capacity for amplitude encoding to provide enriched state …
A Phenomenological Study Of Kindergarten Teachers' Perceptions Of Their Students In The Age Of Kindergarten Readiness., Adam Nelson Stephens
A Phenomenological Study Of Kindergarten Teachers' Perceptions Of Their Students In The Age Of Kindergarten Readiness., Adam Nelson Stephens
Electronic Theses and Dissertations
Kindergarten has changed dramatically from a play-based, social experience a generation ago to the literacy- and numeracy-based curricula of today. With this shift in academic expectations, children now take a kindergarten readiness assessment at the beginning of the school year to determine their likelihood of success based on their pre-kindergarten preparation. While previous studies have examined teachers’ perceptions of current kindergarten practices, expectations, and students, few use teachers’ descriptions as the data (Abry et al., 2015; Hustedt et al., 2018). This phenomenological study reports how kindergarten teachers at three Central Kentucky elementary schools describe their attitudes about their own kindergarten …
Modified-Half-Normal Distribution And Different Methods To Estimate Average Treatment Effect., Jingchao Sun
Modified-Half-Normal Distribution And Different Methods To Estimate Average Treatment Effect., Jingchao Sun
Electronic Theses and Dissertations
This dissertation consists of three projects related to Modified-Half-Normal distribution and causal inference. In my first project, a new distribution called Modified-Half-Normal distribution was introduced. I explored a few of its distributional properties, the procedures for generating random samples based on Bayesian approaches, and the parameter estimation based on the method of moments. The second project deals with the problem of selection bias of average treatment effect (ATE) if we use the observational data. I combined the propensity score based inverse probability of treatment weighting (IPTW) method and the directed acyclic graph (DAG) to solve this problem. The third project …
Assaults On Law Enforcement Officers: A Spatial And Theoretical Analysis Through Social Disorganization., Brian Keith Simpkins
Assaults On Law Enforcement Officers: A Spatial And Theoretical Analysis Through Social Disorganization., Brian Keith Simpkins
Electronic Theses and Dissertations
The purpose of the present study was to gain a better understanding of assaults on law enforcement officers to identify correlations and spatial concentrations related to theoretical constructs of social disorganization. The present study was based on official assault on law enforcement officer data from a major metropolitan area within a southeastern state for the years 2010-2019. In addition to bivariate and multivariate statistical testing (e.g., Pearson correlation coefficient and multiple linear regression), multiple spatial analyses were utilized to understand the statistical significance, visualize results, and compare to previous theoretical explanations of crime concentration. The findings revealed that assaults on …
The Ball Is In Your Court: A Phenomenological Study Examining College Athletes With Learning Disabilities And/Or Adhd On College Campuses., Stephanie Thea O'Donnell
The Ball Is In Your Court: A Phenomenological Study Examining College Athletes With Learning Disabilities And/Or Adhd On College Campuses., Stephanie Thea O'Donnell
Electronic Theses and Dissertations
Approximately only 1% of scholarly top-tier higher education published research focuses on the experiences of students with disabilities since the passing of the ADA in 1990 (Pena, 2014). Even fewer studies have explored the learning-disabled collegiate athlete experience. The purpose of this emerging phenomenological study is to understand the lived experiences of college athletes with learning disabilities and/or ADHD at NCAA Division 1 FBS institutions, giving voice to the untold stories, and commonalities amongst this population. This study provides findings grounded in student perspective by examining their experiences related to disability disclosure, self-advocacy, and academic support within the college environment. …
On The Straight And Narrow: How Cultural Beliefs About Sex/Gender Manifest In College Biology Learning Environments., Katherine Ray Kng
On The Straight And Narrow: How Cultural Beliefs About Sex/Gender Manifest In College Biology Learning Environments., Katherine Ray Kng
Electronic Theses and Dissertations
This dissertation focused on the ways that social beliefs about sex/gender and sexuality manifest in biology classrooms. Especially for health science students, classes include topics like sex, sexuality, sexual behaviors, or sex determination that forms the foundation of their understanding of human forms and behaviors. If the information they receive does not include the LGBTQIA+ community, their education will fail to adequately prepare them for the reality of healthcare practice where they will be expected to treat all patients with dignity and respect. There are three chapters in this dissertation. In chapter one, I asked what beliefs about and conceptions …
External Homophobia And Outness In Gay Men., Thomas Charles Isaak Jr
External Homophobia And Outness In Gay Men., Thomas Charles Isaak Jr
Electronic Theses and Dissertations
Prior studies regarding outness among gay men have often focused on internalized homophobia as a barrier to coming out for gay men, while less emphasis has been placed on external homophobia. Drawing upon social construction theory and Connell’s hierarchy of masculinity, I utilize data from the 2010 Social Justice Sexuality Project to complete an ordinary least square regression to examine the impact of external homophobia on the level of outness among the 987 gay men in this study. In this study, I find that gay men who were exposed to external homophobia reported decreased levels of outness. Further, I find …
College Was A Slap In The Face: Examining The Transition Of Kentucky Appalachian Students Studying Stem At An Urban Institution., Heidi Neal
Electronic Theses and Dissertations
This phenomenological qualitative study examines the lived experience of fourteen rural Appalachian Kentucky (AKY) students studying STEM at an urban university. This study seeks to investigate the unique experiences of AKY students transitioning to STEM majors in college and examines the common factors between their transitional experience into college while addressing compounding factors of a rigorous STEM major and a new cultural setting at an urban institution. This study utilizes Schlossberg’s transitional theory as the framework for analysis. Four key themes emerged from this data: a need for a strong support system, academic preparation, university focus on support and interventions, …
"Don't Put An 'Or' Where God Puts An 'And'": Constitutive Rhetoric In Queer Appalachia., Brooke Elizabeth Boling
"Don't Put An 'Or' Where God Puts An 'And'": Constitutive Rhetoric In Queer Appalachia., Brooke Elizabeth Boling
Electronic Theses and Dissertations
Appalachians who use the word “queer” to specifically refer to being gay, lesbian, bisexual, transgender, queer, intersex, and/or asexual, are regularly faced with negotiating how these parts of their identity can exist simultaneously, as many both within and without the region believe it is impossible to be Appalachian and queer at the same time. Despite rampant homophobia in the region and external narratives suggesting that queer Appalachians do not exist, these folkx have carved out spaces for themselves to assert their identities and create community and belonging through rhetorical actions. Many of these spaces are online, taking place through digital …
Teacher Perceptions Of Collegial Collaboration In An Academy Structure., Kristy Marie Field
Teacher Perceptions Of Collegial Collaboration In An Academy Structure., Kristy Marie Field
Electronic Theses and Dissertations
Collaboration in is an often researched, many-named concept with a definition which has historically been unclear. What one calls collegiality another may call teacher teaming and yet another may refer to as professional networking. Scholars agree effective teacher collaboration can lead to higher student achievement, teacher efficacy, and teacher retention. However, as elusive as an agreed-upon definition may be an agreed-upon structure that fosters an effective version of this collaboration. When Ford began the Ford Next Generation Learning initiative, they embarked on the path to developing a school model that focused on school and community partnerships to support long-term, transformational …
Characterization Of Adiposity And Inflammation Genetic Pleiotropy Underlying Cardiovascular Risk Factors In Hispanics., Mohammad Yaser (Anwar)
Characterization Of Adiposity And Inflammation Genetic Pleiotropy Underlying Cardiovascular Risk Factors In Hispanics., Mohammad Yaser (Anwar)
Electronic Theses and Dissertations
The observed overlap between genetic variants associated with both adiposity and inflammatory markers suggests that changes in both adiposity and inflammation could be partially mediated by common pathways. The pervasive but sparsely characterized “pleiotropic” genetic variants associated with both adiposity and inflammation have been hypothesized to provide insight into the shared biology. This study explored and characterized the genetic pleiotropy underpinning adiposity and inflammation using genetic and phenotypic observations from the Cameron County Hispanic Cohort (CCHC). A total of 3,313 samples and >9 million single nucleotide polymorphisms (SNPs) were examined in this study. Mixed model genome-wide association studies (GWAS) were …
Imparting 3d Representations To Artificial Intelligence For A Full Assessment Of Pressure Injuries., Sofia Zahia
Imparting 3d Representations To Artificial Intelligence For A Full Assessment Of Pressure Injuries., Sofia Zahia
Electronic Theses and Dissertations
During recent decades, researches have shown great interest to machine learning techniques in order to extract meaningful information from the large amount of data being collected each day. Especially in the medical field, images play a significant role in the detection of several health issues. Hence, medical image analysis remarkably participates in the diagnosis process and it is considered a suitable environment to interact with the technology of intelligent systems. Deep Learning (DL) has recently captured the interest of researchers as it has proven to be efficient in detecting underlying features in the data and outperformed the classical machine learning …
Photoelectrical And Photoelectrochemical Characterization Of The Materials Used In Dye-Sensitized And Perovskite Solar Cells., Pom Lal Kharel
Photoelectrical And Photoelectrochemical Characterization Of The Materials Used In Dye-Sensitized And Perovskite Solar Cells., Pom Lal Kharel
Electronic Theses and Dissertations
Solar energy is one of the most important alternative renewable energy sources to fulfill the increasing demand of energy in the world. Third-generation solar cells like dye-sensitized solar cells, perovskite solar cells, quantum dot solar cells, and organic solar cells are extensively studied to increase their photoconversion efficiency, and ultimately for their large-scale implementation. A dye-sensitized solar cell consists of a photoanode of a mesoporous film of titania sensitized with dye sandwiched with a counter electrode, which is usually a platinum-coated transparent conducting oxide, and a redox couple injected between the photoanode and counter electrode. Doping titania with rare-earth metal …
The Sick Ones., Christian Loriel Lucas
The Sick Ones., Christian Loriel Lucas
Electronic Theses and Dissertations
This thesis consists of a collection of linked short stories, connected at the intersections of medicine, public health, race, gender, and socioeconomics. The Sick Ones was completed during a time of social unrest and the emergence of the Covid-19 virus. Inspired by medicine’s history of exploiting sick, poor, and racialized bodies, The Sick Ones explores the treatment of illness and societal woes in a near-speculative future. Each story is plot-driven, but complimented by a protagonist who keeps the narrative grounded, as they attempt to survive unprecedented circumstances. Some of the protagonists are complicit in their own medical exploitations, while others …
Fly-In Visualization Of Tubular Objects: Theory And Application In Virtual Colonoscopy., Mostafa Mohamed
Fly-In Visualization Of Tubular Objects: Theory And Application In Virtual Colonoscopy., Mostafa Mohamed
Electronic Theses and Dissertations
In this dissertation, visualization for tubular objects, i.e., projecting 2D images from 3D inner surfaces of tubular objects, is investigated. Given surface points on 3D objects, an approach that most accurately and effectively projects 2D images from the 3D surface with minimal loss of information is desired. A new visualization method for tubular surfaces is proposed, denoted by "Fly-In". The approach uses a virtual camera ring that moves along the inner surface's centerline, obtaining projections of the surrounding views, forming small 3D topological rings within the tube rendered as a 2D rectangular image. A new visualization loss measure is also …
The Green House Nursing Home Model: The Gh Elements And Their Impact On Quality Of Care In Nursing Homes., Deborah Kaminka Niyongabo
The Green House Nursing Home Model: The Gh Elements And Their Impact On Quality Of Care In Nursing Homes., Deborah Kaminka Niyongabo
Electronic Theses and Dissertations
Nursing homes (NHs) have been described as hospital-like facilities where residents are more likely to experience isolation or abuse. The Green House (GH) model is a type of culture change which focuses on deinstitutionalizing traditional NHs to provide better quality of care and quality of life to NH residents. The two main objectives of this study are: to describe the GH model and its elements and to identify which GH elements impact the quality of care. This study also seeks to identify organizational theories used in the GH analysis. The next objective is to analyze the impact of the GH …
Statistical Approaches Of Gene Set Analysis With Quantitative Trait Loci For High-Throughput Genomic Studies., Samarendra Das
Statistical Approaches Of Gene Set Analysis With Quantitative Trait Loci For High-Throughput Genomic Studies., Samarendra Das
Electronic Theses and Dissertations
Recently, gene set analysis has become the first choice for gaining insights into the underlying complex biology of diseases through high-throughput genomic studies, such as Microarrays, bulk RNA-Sequencing, single cell RNA-Sequencing, etc. It also reduces the complexity of statistical analysis and enhances the explanatory power of the obtained results. Further, the statistical structure and steps common to these approaches have not yet been comprehensively discussed, which limits their utility. Hence, a comprehensive overview of the available gene set analysis approaches used for different high-throughput genomic studies is provided. The analysis of gene sets is usually carried out based on …
Design, Synthesis And Application Of Janus Gold Nanoprisms For Directed Self-Assembly., Md. Emtias Chowdhury
Design, Synthesis And Application Of Janus Gold Nanoprisms For Directed Self-Assembly., Md. Emtias Chowdhury
Electronic Theses and Dissertations
Colloidal Janus particles that possess more than one type of surface chemistry or functionalities have drawn significant interest due to their enormous potential in bottom-up synthetic strategies for complex superstructures. Moreover, the property of molecular recognition, tunability, and predictability of the DNA-mediated interactions enable a high degree of control over particle assembly to generate highly ordered nanostructures with emergent applications. In this dissertation, we present our works on the synthesis of Janus particles from anisotropic gold nanoprisms, and DNA- mediated assembly of nanoprisms and polymer beads in four major areas: 1) Facet selective asymmetric functionalization of gold nanoprisms for Janus …
Investigating The Disorder And Compaction Of Designed Minielastin Using Nuclear Magnetic Resonance., Ma Faye Charmagne Aquino Carvajal
Investigating The Disorder And Compaction Of Designed Minielastin Using Nuclear Magnetic Resonance., Ma Faye Charmagne Aquino Carvajal
Electronic Theses and Dissertations
Minielastins are elastin-based proteins with alternating hydrophobic and cross-link modules similar to tropoelastin. Tropoelastin is the ~70 kDa soluble monomeric precursor of elastin. The extracellular matrix protein, elastin provides elasticity to tissues and organs such as lungs, arteries and ligaments. The elastic properties of natural elastin are believed to be entropic in origin. In vivo, the elastin matrix is approximately 50% water by weight. Without water, elastin is brittle and hard. Minielastins, like tropoelastin, undergo a liquid-liquid phase transition upon an increase in temperature. Factors such as hydrophobicity, chain length and concentration affect the coacervation temperature, Tc. The …
Mitigating Black Claustrophobia: Space, Trauma, And Healing Modalities In The Postcolonial Narrative., Saleema Mustafa Campbell
Mitigating Black Claustrophobia: Space, Trauma, And Healing Modalities In The Postcolonial Narrative., Saleema Mustafa Campbell
Electronic Theses and Dissertations
This dissertation examines the space or spaces of blackness and the black body in the United States. This nation was shaped by the institution of slavery, and its greatest legacy is the trauma that still resonates in social structures and spaces complicating the lived experiences of many. The various responses to these traumas are documented in literary form by authors who serve as cultural witnesses. The narratives featured in this research project, collectively and individually, offer a voice to the traumatic plight of individuals in the U.S. who struggle to contemplate and rectify the traumas of this nation’s past. This …
Kindergarten Readiness And Grade 1 Mathematics Achievement., Faneshia Mcpherson Jones
Kindergarten Readiness And Grade 1 Mathematics Achievement., Faneshia Mcpherson Jones
Electronic Theses and Dissertations
From 2013-2019, all Kentucky school districts have administered a common screener to each student entering kindergarten. In this study, kindergarten readiness—determined by academic skills/cognitive development, language development, and physical development—was a significant predictor of grade 1 end-of-year mathematics achievement. The model predictions show that kindergarten students who met the readiness benchmark had higher grade 1 end-of-year mathematics scores compared to students who entered kindergarten below the readiness benchmark. The model predictions improved substantially with the inclusion of prior level of achievement as indicated by grade 1 beginning of the year mathematics achievement. However, students with stronger readiness skills demonstrated significantly …
Development Of A Pediatric Cardiac Assist Maglev Pump For Use With A Universal Driver System., Landon Heath Tompkins
Development Of A Pediatric Cardiac Assist Maglev Pump For Use With A Universal Driver System., Landon Heath Tompkins
Electronic Theses and Dissertations
Heart failure (HF) remains the leading cause of death, affecting 26 million adults worldwide and 6.5 million adults in the United States. Pediatric HF patients have been a historically underserved population with few options for mechanical circulatory support (MCS) therapy, a leading treatment as an alternative to heart transplantation. To address this clinical need, the Inspired Universal MagLev System is being developed; a low cost, universal magnetically levitated extracorporeal MCS system with interchangeable single-use pumps that will ultimately provide adult and pediatric patients ventricular and respiratory assist therapies. The Inspired Pediatric VAD is the first single-use pump application for this …
Modeling And Analysis For Unit Cell Size, Material Anisotropy And Material Imperfection Effects Of Cellular Structures Fabricated By Powder Bed Fusion Additive Manufacturing., Yan Wu
Electronic Theses and Dissertations
Cellular structures are networks of interconnected struts or walls with porosities and are widely found in many natural load-bearing structures such as plants and bones. Cellular structures offer unique functional characteristics such as high stiffness to weight ratio, tailorable heat transfer coefficient, and enhanced mechanical energy absorption, which makes them highly attractive in various engineering disciplines such as biomedical implants, electrodes, heat exchangers, and lightweight structures. There exists an abundance of literatures that have investigated various mechanical properties of various cellular structures such as Poisson’s ratio, elastic modulus, ultimate strength, yield strength, and failure characteristics. Based on the classic cellular …
Fostering African American Female Students’ Sense Of Belonging: A Digital Storytelling Participatory Action Research Approach., Rajwinder Kaur
Fostering African American Female Students’ Sense Of Belonging: A Digital Storytelling Participatory Action Research Approach., Rajwinder Kaur
Electronic Theses and Dissertations
This Participatory Action Research dissertation discovers what fosters or diminishes school sense of belonging for African American female students. This is achieved by foregrounding the voices of the individual participants and the collective voice of those within this study. Both Critical Race Theory and Black Feminist Thought guide this dissertation study to ensure the intersectionality between race and gender is addressed. Data for this study was collected during five workshop sessions, where participants created digital stories on their sense of belonging. The findings revealed the importance of students’ racial identity, family, peer relationships, fitting in, safety, and being seen/heard by …
The Many Facets Of Trauma - High Need Index School Principals' Perspectives Of Trauma-Informed Care., Nicole Michelle Fields
The Many Facets Of Trauma - High Need Index School Principals' Perspectives Of Trauma-Informed Care., Nicole Michelle Fields
Electronic Theses and Dissertations
This qualitative phenomenological study attempts to add to the literature by shedding light on the best practices for fostering and applying effective trauma-informed care (TIC) in schools and the educational practices and policies through human experience elements. Creating trauma-sensitive, safe, and supportive schools requires a new discernment among principals. It also requires holistic changes to transform school, culture, build supporting infrastructure, and alter curriculum content and intervention (McInerney & McKlindon, 2014). TIC refers to treating the whole person mentally, socially, emotionally, and physically. This study interview 14 principals' perspectives in a large urban school district to discover what practices, procedures, …
Evaluating The Effects Of Pcbs In Non-Alcoholic Fatty Liver Disease & Diabetes And The Role Of Ahr In Regulating The Hepatic Proteome And Lipid Metabolism., Jian Jin
Electronic Theses and Dissertations
Polychlorinated biphenyls (PCBs) are persistent organic pollutants associated with non-alcoholic fatty liver disease (NAFLD) and diabetes. Based on their ability to activate the aryl hydrocarbon receptor (AhR), PCBs are subdivided into two classes: dioxin-like (DL) and non- dioxin-like (NDL) PCBs. This study not only evaluated the chronic effect of DL PCBs (PCB126), NDL PCBs (Aroclor1260 mainly contains NDL), and the DL/NDL PCB mixture (PCB126/Aroclor1260 mixture) on liver, but also explored the acute hepatic effects of DL PCB and potential mechanisms in NAFLD and the role of AhR in regulating hepatic proteome and lipid metabolism, and whether the process independent of …
Social Media And Fear: Social Media As A Catalyst For Political Fear In The United States., Shane R. White
Social Media And Fear: Social Media As A Catalyst For Political Fear In The United States., Shane R. White
Electronic Theses and Dissertations
Abstract: Using the American National Election Study data from the 2012 and 2016 surveys I explore how social media usage shapes fear. This is likely caused by the nature of social media leading to oversharing of sensationalized articles likely to elicit an emotional and fearful response. My findings suggest first that social media usage has a statistically significant effect on whether they would say they are afraid of a candidate (2012) and how afraid they say they are of the candidates (2016). Second, social media has little effect on economic fear, and may actually make people more hopeful about the …
Structural Characterization And Selective Drug Targeting Of Higher-Order Dna G-Quadruplex Systems., Robert Chandos Monsen
Structural Characterization And Selective Drug Targeting Of Higher-Order Dna G-Quadruplex Systems., Robert Chandos Monsen
Electronic Theses and Dissertations
There is now substantial evidence that guanine-rich regions of DNA form non-B DNA structures known as G-quadruplexes in cells. G-quadruplexes (G4s) are tetraplex DNA structures that form amid four runs of guanines which are stabilized via Hoogsteen hydrogen bonding to form stacked tetrads. DNA G4s have roles in key genomic functions such as regulating gene expression, replication, and telomere homeostasis. Because of their apparent role in disease, G4s are now viewed as important molecular targets for anticancer therapeutics. To date, the structures of many important G4 systems have been solved by NMR or X-ray crystallographic techniques. Small molecules developed to …