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Iot In Smart Communities, Technologies And Applications., Muhammad Zaigham Abbas Shah Syed
Iot In Smart Communities, Technologies And Applications., Muhammad Zaigham Abbas Shah Syed
Electronic Theses and Dissertations
Internet of Things is a system that integrates different devices and technologies, removing the necessity of human intervention. This enables the capacity of having smart (or smarter) cities around the world. By hosting different technologies and allowing interactions between them, the internet of things has spearheaded the development of smart city systems for sustainable living, increased comfort and productivity for citizens. The Internet of Things (IoT) for Smart Cities has many different domains and draws upon various underlying systems for its operation, in this work, we provide a holistic coverage of the Internet of Things in Smart Cities by discussing …
The Effects Of Stigma On Quality Of Life And Psychological Outcomes In Participants With Varying Reports Of Subjective Cognitive Decline., Lauren Flaherty
The Effects Of Stigma On Quality Of Life And Psychological Outcomes In Participants With Varying Reports Of Subjective Cognitive Decline., Lauren Flaherty
Electronic Theses and Dissertations
Background: Diagnostic labels such as cognitive impairment, dementia or MCI often carry associated stigmatization. Stigma can lead to social isolation and rejection; increasing the likelihood of loneliness, depression, and anxiety. Depression and anxiety can be predictive of cognitive function; depression and anxiety are linked to stigma. Subjective cognitive decline (SCD) can be indicative of actual cognitive impairment. Subjective impairment and stigma can significantly predict quality of life. The aim of the proposed dissertation study was to explore whether higher SCD scores associate with more internalized stigma, and if this stigma mediates the relationship between SCD and depression, SCD and …
Academic Achievement And Degree Attainment Among College Students With Children., Katrina Elliott
Academic Achievement And Degree Attainment Among College Students With Children., Katrina Elliott
Electronic Theses and Dissertations
Using data from the Beginning Postsecondary Students Longitudinal Study (BPS) (National Center for Education Statistics, n.d.) from 2012 to 2017 acquired by the National Center for Education Statistics (NCES) survey program, this study addresses the research questions of whether there is a difference in degree attainment of earning a bachelor’s degree in the time period from 2012 through 2017 and whether there is a difference in academic achievement as defined by students’ grade point average between students who have dependent children and those who do not have dependent children between the ages 18 to 29 attending a four-year institution after …
Understanding Neuroanatomy In A Virtual 3d Environment: Creation And Use Of A New Survey Tool To Evaluate The Effectiveness Of 3d Software In Neuroanatomy Education For Understanding Superficial And Deep Brain Structures., Akash Khare
Electronic Theses and Dissertations
Studying cross-sections is a critical approach to learning and testing knowledge in neuroanatomy and the role of 3D technologies have been gradually increasing in medical education, especially after the COVID-19 pandemic. A study was conducted in a quasi-experimental one-group pre-post interventional design in an online setting by creating and evaluating the effectiveness of a virtual lab in neuroanatomy for all neuroscience students enrolled in the Fundamentals of Neuroscience course in our department at the University of Louisville. Study modules were created using the 2D resources used in previous years and 3D web applications of Visible Body and AnatomyLearning.com software. A …
La Casita Center: An Accompaniment Based Approach To Social Justice And Social Service., Ben Harlan
La Casita Center: An Accompaniment Based Approach To Social Justice And Social Service., Ben Harlan
Electronic Theses and Dissertations
La Casita Center is a Louisville based nonprofit organization that accompanies Latinx immigrants in the Louisville Metro area. and that is led and staffed by Latina immigrants. In this thesis, I investigate how employees of this Latinx-immigrant led nonprofit organization, navigate challenges to both administer service and build community using the model of accompaniment. Organizations like La Casita are critically important for Latinx newcomer communities in the United States and as neoliberal and nativist-inspired policiescontinue to oppress and marginalize, La Casita provides a model for what it means to center inclusion, belonging, community, and solidarity. In a global landscape of …
Investigation Of Human N-Acetyltransferases (Nat1 And Nat2) Genetic Polymorphisms In Susceptibility To Aromatic Amine And Alkylaniline Genotoxicity., Mariam Habil
Electronic Theses and Dissertations
Arylamine N-acetyltransferases, NAT1 and NAT2, catalyze the detoxification and/or activation of carcinogens. Single nucleotide polymorphisms or SNPs result in different human NAT1 and NAT2 genotypes. We hypothesize that different NATs alleles will impact levels of N-acetylation, HPRT mutations, DNA damage and oxidative stress induced by carcinogens. NER-deficient Chinese hamster ovary (CHO) cells transfected with human CYP1A2 and NAT1*4, NAT1*14B, NAT2*4, NAT2*5B or NAT2*7B have been used to investigate N-acetylation of benzidine, β-naphthylamine (BNA), and 4, 4’-methylene bis (2-chloroaniline) (MOCA) as aromatic amines and 3,4-dimethylaniline (3,4-DMA) as one of alkylanilines and their associated toxicity. Our …
Re-Engineering Cardio-Oncology Testing Using Biomimetic Heart Slice Cultures., Jessica Miller
Re-Engineering Cardio-Oncology Testing Using Biomimetic Heart Slice Cultures., Jessica Miller
Electronic Theses and Dissertations
28% of drug withdrawal from the market are due to unforeseen disruptions in cardiomyocyte contractility and electrophysiology. The most commonly used platforms for drug testing are in vivo animal models and in vitro cell culture models. While both have been of paramount importance for the discovery and detection of many cardiotoxicities and mechanisms of action, they lack the ability to model an intact human myocardium. This work aims to establish cardiac tissue slices, which are 300-micron thin tissue sections taken from the left ventricular myocardium, as an alternative platform for cardio-oncology studies, specifically cardiotoxicity testing. Additionally, this work aims to …
Teachers' Perceptions Of Professional Development And Pedagogical Practice: A Study Of A Kentucky Suburban School District., Rachelle Bramlage-Schomburg
Teachers' Perceptions Of Professional Development And Pedagogical Practice: A Study Of A Kentucky Suburban School District., Rachelle Bramlage-Schomburg
Electronic Theses and Dissertations
Professional development supports teacher growth and enhances pedagogical practice. Teachers in Kentucky must complete annual professional development hours and districts must develop a professional development plan tied to research that supports high-quality professional development. This qualitative case study takes place in a rural district, Bullitt County, where I investigated the teachers’ perception of a customized professional development, Thinking Focus Cohort (TFC), and its impact on their pedagogical practice. While a body of research exists on high quality professional development, there is a lack of research on the effectiveness of it, in particular a year-long cohort model with curriculum centered around …
Alpha, Beta-Unsaturated Aldehydes: The Underrepresented Markers Of Disease., Saurin Sutaria
Alpha, Beta-Unsaturated Aldehydes: The Underrepresented Markers Of Disease., Saurin Sutaria
Electronic Theses and Dissertations
The peroxidation of unsaturated fatty acids is a widely recognized metabolic process that creates a complex mixture of volatile organic compounds including aldehydes. Elevated levels of reactive oxygen species in cancer cells promote random lipid peroxidation, which leads to an increase in a variety of aldehydes. Many of these volatile aldehydes are exhaled and are of interest as potential markers of disease. Chapter 1 presents a review of reported aldehydes in the exhaled breath of lung cancer patients. alpha,beta-Unsaturated aldehydes, detected primarily when derivatized during exhaled breath preconcentration, are underreported in the reviewed articles. Chapter 1 concludes with our hypothesis …
Examining The Effects Of Npra Antagonist Anantin On Sci-Induced Ployuria., Lindsey Zipperer
Examining The Effects Of Npra Antagonist Anantin On Sci-Induced Ployuria., Lindsey Zipperer
Electronic Theses and Dissertations
Polyuria, or the over production of urine, is a prevalent condition that significantly impacts the quality of life in individuals suffering from a spinal cord injury (SCI). Post-SCI induced polyuria is thought to have been associated with altered levels of vasopressin (AVP), atrial natriuretic peptide (ANP), and natriuretic peptide receptor A (NPRA). In the present study, the function of NPRA was analyzed in the rat contusion model using anantin, an NPRA antagonist. A daily dose of either 100 µg of anantin or vehicle was administered intraperitoneally immediately following the SCI surgery and continued until termination, 4 weeks post injury (wpi). …
Examining Effective And Realized Healthcare Access In The West South Central Division., Katherine Cameron
Examining Effective And Realized Healthcare Access In The West South Central Division., Katherine Cameron
Electronic Theses and Dissertations
This study explores realized and effective access domains outlined by Andersen’s Behavioral Model of Health Services Use. Exploring other domains of access is critical to understanding how the healthcare system functions (Kirby & Yabroff, 2020). This study evaluates rural-urban and racial/ethnic differences in access to care using two underresearched domains of healthcare access. It also allows for exploring access disparities within rural communities amongst minority populations. This dissertation is divided into five chapters. Chapter One provides an overview of health disparities and inequities and a brief overview of the study. Chapter Two details a high-level history of racism and its …
Nonlinear Observers For Burning Zone Temperatures And Torque Estimation Of The Rotary Cement Kiln., Bhagyashri Aditya Bhagwat
Nonlinear Observers For Burning Zone Temperatures And Torque Estimation Of The Rotary Cement Kiln., Bhagyashri Aditya Bhagwat
Electronic Theses and Dissertations
Due to consistent expansion in the infrastructure and housing sectors worldwide have given a new way for the rapid growth of global cement market. Increased global demand for the cement production makes the attractive research topic which can lead to the quality and overall efficiency of the product. Measurement of the temperature in the burning zone is vital to maintain product quality and kiln efficiency in the cement industry. Often the BZT is un-measurable due to internal kiln conditions, dusty environment, extreme heat, harshness for example and this leads to kiln not being driven as efficient as possible. Multi-physics tools …
Death Of A Bacterium: Exploring The Inhibition Of Staphylococcus Aureus By Burkholderia Cenocepacia., Tiffany Brandt
Death Of A Bacterium: Exploring The Inhibition Of Staphylococcus Aureus By Burkholderia Cenocepacia., Tiffany Brandt
Electronic Theses and Dissertations
Antimicrobial resistance is a phenomenon of increasing concern as antimicrobial overuse and misuse eliminate current therapeutic options, ushering society into a post-antimicrobial era. Antibiotic discovery and synthesis efforts are urgently needed to counter the increasing burden of antimicrobial resistance. Staphylococcus aureus is a causative agent of a variety of clinical manifestations including bacteremia, endocarditis, soft tissue infection, osteomyelitis, and device-related infections. S. aureus infection presents additional treatment challenges due to its capacity for biofilm formation, which is a mode of growth that confers protection from antibiotics and physical elimination, and the emergence of antibiotic resistant strains, including methicillin-resistant S. aureus …
Voltage-Gated Potassium Channel Dependent Mechanisms Of Cardiovascular Adaptation To Chronic Exercise., Sean Raph
Electronic Theses and Dissertations
Exercise increases cardiac workload, escalating the demand for oxygen. The myocardial vasculature responds to the greater demand for oxygen by increasing blood flow to match the needs of the heart during augmented work. Increasing blood flow requires the coronary arteries dilate (a.k.a. vasodilation); this is mediated predominantly by vascular smooth muscle cell relaxation. Vasodilation is driven through inhibition of calcium influx into vascular smooth muscle cells. The prevention of calcium influx is largely mediated by efflux of potassium via potassium channels causing membrane hyperpolarization, which in turn closes voltage-dependent (or gated) calcium channels (VDCC). Changes in vascular smooth muscle cell …
Sro Roles And Teacher Behavioral Intervention Strategies: An Analysis On Behavioral Approaches And Student Suspensions., Ivan Benitez
Sro Roles And Teacher Behavioral Intervention Strategies: An Analysis On Behavioral Approaches And Student Suspensions., Ivan Benitez
Electronic Theses and Dissertations
Recently there have been nationwide calls for schools to end their contracts with local police departments in efforts to remove school resource officers (SROs) due to their criminalizing effect on students. Aiming towards racial equity in safety and discipline, advocates have suggested re-envisioning discipline through a restorative lens to minimize student harm. One approach which has been promising in student outcomes are behavioral intervention strategies. The current study contributes to the literature by examining the direct effects of SRO roles and teacher behavioral intervention strategies on student suspensions. Using factor analysis, I found three SRO roles: law enforcement officer, mentor, …
Anion Alloying Of Iii-V Semiconductors For Water Splitting., Sonia Calero-Barney
Anion Alloying Of Iii-V Semiconductors For Water Splitting., Sonia Calero-Barney
Electronic Theses and Dissertations
The challenge of solar energy conversion and storage translates into the discovery and development of semiconductor materials that can transform sunlight energy into electricity and/or high-energy-density fuels in a cost-effective way. From the solar energy conversion perspective, cation-alloyed III-V solar cells hold record-breaking energy conversion efficiencies, while anion-alloyed III-V’s are particularly interesting for photoelectrochemical hydrogen generation. The major challenge for the adoption of III-V-based technologies lies in the high manufacturing costs of established synthesis techniques and the difficulty to control the composition of ternary alloys. One of the materials investigated in this work is GaSbzP1-z. Thermodynamic …
Design, Evaluation, And Control Of Nexus: A Multiscale Additive Manufacturing Platform With Integrated 3d Printing And Robotic Assembly., Danming Wei
Electronic Theses and Dissertations
Additive manufacturing (AM) technology is an emerging approach to creating three-dimensional (3D) objects and has seen numerous applications in medical implants, transportation, aerospace, energy, consumer products, etc. Compared with manufacturing by forming and machining, additive manufacturing techniques provide more rapid, economical, efficient, reliable, and complex manufacturing processes. However, additive manufacturing also has limitations on print strength and dimensional tolerance, while traditional additive manufacturing hardware platforms for 3D printing have limited flexibility. In particular, part geometry and materials are limited to most 3D printing hardware. In addition, for multiscale and complex products, samples must be printed, fabricated, and transferred among different …
Ideas In Communities: A Micro-Perspective On Entrepreneurial Ecosystems., Malcolm Muhammad
Ideas In Communities: A Micro-Perspective On Entrepreneurial Ecosystems., Malcolm Muhammad
Electronic Theses and Dissertations
Entrepreneurial ecosystems are seen as a stimulant of regional economic growth. Theory-building efforts on entrepreneurial ecosystems has sufficiently established an understanding of the macro-environment; the environmental infrastructure and conditions that support productive entrepreneurship. However, there has been a disproportionate lack of focus on the micro- and group-level dynamics that impact individual entrepreneurs and ventures within ecosystem. This has limited the availability of evidence to explain how and when ecosystems emerge and function at a high level. Therefore, this dissertation examines three distinct microfoundations that can be found in entrepreneurial ecosystem literature – community, learning, and venture development – to move …
Bayesian Methods For Graphical Models With Neighborhood Selection., Sagnik Bhadury
Bayesian Methods For Graphical Models With Neighborhood Selection., Sagnik Bhadury
Electronic Theses and Dissertations
Graphical models determine associations between variables through the notion of conditional independence. Gaussian graphical models are a widely used class of such models, where the relationships are formalized by non-null entries of the precision matrix. However, in high-dimensional cases, covariance estimates are typically unstable. Moreover, it is natural to expect only a few significant associations to be present in many realistic applications. This necessitates the injection of sparsity techniques into the estimation method. Classical frequentist methods, like GLASSO, use penalization techniques for this purpose. Fully Bayesian methods, on the contrary, are slow because they require iteratively sampling over a quadratic …
Rehabilitation Length Of Stay In Individuals With Spinal Cord Injury Paraplegia., Sahal Alzahrani
Rehabilitation Length Of Stay In Individuals With Spinal Cord Injury Paraplegia., Sahal Alzahrani
Electronic Theses and Dissertations
Background: Spinal Cord Injury (SCI) is associated with functional and physical limitations as well as psychological challenges. Rehabilitation care is crucial to SCI individuals’ overall health. It is recommended that individuals with SCI receive an intensive and early rehabilitation care to improve their health and avoid medical complications. Hospitals and rehabilitation facilities use length of stay (LOS) as a proxy to quantify rehabilitation care and a measure for quality of care. Objectives: This dissertation has three aims: 1) to identify factors associated with rehabilitation LOS in paraplegia populations, 2) to examine trends of inpatients rehabilitation LOS in SCI paraplegia between …
Reaching Syrians In Need: An Analysis Of Humanitarian Aid In The 21st Century., James Clark
Reaching Syrians In Need: An Analysis Of Humanitarian Aid In The 21st Century., James Clark
Electronic Theses and Dissertations
The objective of this dissertation is two-fold. One is to critically consider humanitarian aid delivery to and through Syria via a lens that combines the humanities and social sciences. The fields of anthropology, political science and postcolonialism are employed to accomplish this. The second is to investigate the process involved in this delivery amid the country’s ongoing conflict. Combining these two facets provides a view of humanitarian aid as it relates to the conflict in Syria while applying a liberal arts-humanities approach. The introduction establishes the basis to discuss the existence of aid providers and those in need of aid …
The Impact Of Volatile Organic Compound Exposure On Subclinical Biomarkers Of Cardiovascular Injury., Breandon Taylor
The Impact Of Volatile Organic Compound Exposure On Subclinical Biomarkers Of Cardiovascular Injury., Breandon Taylor
Electronic Theses and Dissertations
Pollution has been identified as the leading environmental cause of non-communicable disease and premature deaths globally. Volatile organic compounds (VOCs) are gaseous chemical constituents of pollution derived from a variety of sources, including industrial solvents and byproducts, automobile exhaust, tobacco smoke, cleaning supplies, and personal care products. VOCs are also abundant at various Superfund and Hazardous Waste Sites. Emerging data suggest that VOC exposure is associated with several adverse health outcomes, including cardiovascular disease (CVD). VOCs and their metabolites can potentially damage the endothelial lining of blood vessels, resulting in perturbed vascular function and vascular inflammation. We hypothesize that VOC …
Foreign Policy In Media: An Examination Of The Captain America Films., Kat Hernandez
Foreign Policy In Media: An Examination Of The Captain America Films., Kat Hernandez
Electronic Theses and Dissertations
Popular culture and media are consumed daily by billions around the world, media which can contain meaningful and politically relevant material. The three Captain America films from the 2010s represent this phenomenon in the presentation of Captain America as a nationalist superhero with geopolitically relevant storylines. The direction and production of these films illustrate significant parallels to foreign policy choices of the United States. Through an interpretive analysis of the Captain America films: Captain America: The First Avenger, Captain America: The Winter Soldier, and Captain America: Civil War, this project seeks to analyze Captain America’s image and …
The Role Of Mri In Diagnosing Autism: A Machine Learning Perspective., Yaser Elnakieb
The Role Of Mri In Diagnosing Autism: A Machine Learning Perspective., Yaser Elnakieb
Electronic Theses and Dissertations
There is approximately 1 in every 44 children in the United States suffers from autism spectrum disorder (ASD), a disorder characterized by social and behavioral impairments. Communication difficulties, interpersonal difficulties, and behavioral difficulties are the top common symptoms. Even though symptoms can begin as early as infancy, it may take multiple visits to a pediatric specialist before an accurate diagnosis can be made. In addition, the diagnosis can be subjective, and different specialists may give different scores. There is a growing body of research suggesting differences in brain development and/or environmental and/or genetic factors contribute to autism development, but scientists …
The Effect Of Volatile Organic Compounds On Endothelial Function And Atherogenesis., Samantha Mcfall
The Effect Of Volatile Organic Compounds On Endothelial Function And Atherogenesis., Samantha Mcfall
Electronic Theses and Dissertations
Volatile organic compounds (VOCs) are a group of pervasive air pollutants that are released into the atmosphere from both anthropogenic and environmental sources. Recent epidemiological studies suggest that exposure to various VOCs is associated with an increased risk of cardiovascular disease. However, the relationship between VOCs and cardiovascular disease is not well-studied. Using animal models and three select VOCs, benzene, xylene, and trichloroethylene, we studied the effects of VOCs on endothelial injury and benzene-induced atherogenesis. We found that exposure to benzene and xylene increased circulating endothelial microparticles, depleted progenitor cells, and increased platelet activation. Following the exposure to the representative …
The Impact Of Pegylation On Cellular Uptake And In Vivo Biodistribution Of Gold Nanoparticle Mri Contrast Agents., Nagwa El-Baz
The Impact Of Pegylation On Cellular Uptake And In Vivo Biodistribution Of Gold Nanoparticle Mri Contrast Agents., Nagwa El-Baz
Electronic Theses and Dissertations
Gold nanoparticles (GNPs) have become a pivotal platform for the delivery of pharmaceutical and diagnostic agents as well as for general therapeutic purposes. Despite their potential for use in biomedicine, their interaction with serum proteins is crucial as it could change their biological profile due to the formation of a protein corona, which can affect their delivery to target tissues in the body. Grafting the GNPs with polyethylene glycol (PEG) is widely used in research to decrease opsonization of the particles by serum proteins and decrease the uptake by the reticuloendothelial system. Here in this dissertation, we have developed a …
Metabolic Foundations Of Exercise-Induced Cardiac Growth., Kyle Fulghum
Metabolic Foundations Of Exercise-Induced Cardiac Growth., Kyle Fulghum
Electronic Theses and Dissertations
Regular aerobic exercise promotes physiological cardiac growth, which is an adaptive response thought to enable the heart to meet higher physical demands. Cardiac growth involves coordination of catabolic and anabolic activities to support ATP generation, macromolecule biosynthesis, and myocyte hypertrophy. Although previous studies suggest that exercise-induced reductions in cardiac glycolysis are critical for physiological myocyte hypertrophy, it remains unclear how exercise influences the many interlinked pathways of metabolism that support adaptive remodeling of the heart. In this thesis project, we tested the general hypothesis that aerobic exercise promotes physiological cardiac growth by coordinating myocardial metabolism to promote glucose-supported anabolic pathway …
Effects Of Top-Down Attention And Individual Differences On Recognition Memory And Recollective Experience., Anna Kelley
Effects Of Top-Down Attention And Individual Differences On Recognition Memory And Recollective Experience., Anna Kelley
Electronic Theses and Dissertations
Memory accuracy and detail hold practical importance, and psychology has studied means to improve memory. One such means is performing visually guided saccades immediately before a memory test. Previous work has found this intervention to improve memory performance, an effect dubbed Saccade-Induced Retrieval Enhancement or SIRE. The top-down attentional control account posits that SIRE occurs because saccades activate attentional control regions in the brain, which contributes to executing top-down attentional control when searching memory. The current experiment tested this account of SIRE by attempting to replicate previous results and investigating whether a different attentional task, the Revised Attention Network Test …
Wet Chemical Synthesis And Properties Of Argyrodite Sulfide Solid Electrolytes For Solid State Lithium Batteries., William Arnold
Wet Chemical Synthesis And Properties Of Argyrodite Sulfide Solid Electrolytes For Solid State Lithium Batteries., William Arnold
Electronic Theses and Dissertations
The commercialization of the lithium-ion battery (LIB) in 1991 was responsible for the explosion in portable electronic technologies that has been seen over the past 30 years. With the advent of electric vehicles and other high-powered technologies, there is tremendous demand for LIBs with higher energy density and high safety. To achieve this, new electrode materials must be explored. The obvious choice of anode material would be pure metal lithium, which has a theoretical specific capacity of 3860 mAh g-1 . Unfortunately, metal lithium anodes have not been widely commercialized due to their tendency to react violently with the …
A New Direction For Public Understanding Of Science: Toward A Participant-Centered Model Of Science Engagement., Christopher Rickels
A New Direction For Public Understanding Of Science: Toward A Participant-Centered Model Of Science Engagement., Christopher Rickels
Electronic Theses and Dissertations
Engaging the public with science is not an easy task. When presented, scientific findings, public health recommendations, and other scientific information filter through the personal values, beliefs, and biases of members of the public. Science communicators must contend with these differences in order to be effective in cultivating a public understanding of science. Given the importance of scientific understanding for living well in a complex world, increasing science understanding through science engagement is imperative. The field of public engagement with science is dichotomized by a public information deficit approach and a contextualist approach. The deficit approach prizes the factual content …